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Volumn 27, Issue 1, 2018, Pages 246-256

Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics

(19)  Behrouz, Réza a   Masjuán Vallejo, Jaime b   Vera, Rocío b   Willey, Joshua Z c   Zedet, Mickael d   Moulin, Solène d   Cordonnier, Charlotte d   Klijn, Catharina J M e   Kanselaar, Karin e   Dirks, Maaike f   Silver, Brian g   Khan, Muhib h   Azarpazhooh, Mahmoud R i,j   Godoy, Daniel A k   Roffe, Christine l   Paley, Lizz m   Bray, Benjamin D n   Smith, Craig J o,p   Di Napoli, Mario q,r  


Author keywords

acute stroke; Acute stroke treatment; elderly; nonagenarian; thrombolysis

Indexed keywords

ALTEPLASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

EID: 85029545883     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2017.08.031     Document Type: Article
Times cited : (19)

References (34)
  • 1
    • 84995371486 scopus 로고    scopus 로고
    • An aging world: 2015; International population reports
    • Available at: (Accessed 16 May 2016)
    • United States Census Bureau, An aging world: 2015; International population reports. Available at: https://www.census.gov/content/dam/Census/library/publications/2016/demo/p95-16-1.pdf. (Accessed 16 May 2016)
    • United States Census Bureau1
  • 2
    • 85042431299 scopus 로고    scopus 로고
    • Comprehensive analysis of fast-growing 90-and-older population
    • Available at: (Accessed 16 May 2016)
    • United States Census Bureau, Comprehensive analysis of fast-growing 90-and-older population. Available at: https://www.census.gov/newsroom/releases/archives/aging_population/cb11-194.html. (Accessed 16 May 2016)
    • United States Census Bureau1
  • 3
    • 65449176101 scopus 로고    scopus 로고
    • Stroke in the very elderly: hospital care, case fatality and disposition
    • Saposnik, G., Black, S., Stroke in the very elderly: hospital care, case fatality and disposition. Cerebrovas Dis 27 (2009), 537–543.
    • (2009) Cerebrovas Dis , vol.27 , pp. 537-543
    • Saposnik, G.1    Black, S.2
  • 4
    • 84874510640 scopus 로고    scopus 로고
    • Stroke thrombolysis in England: an age stratified analysis of practice and outcome
    • Bray, B.D., Campbell, J., Hoffman, A., et al. Stroke thrombolysis in England: an age stratified analysis of practice and outcome. Age Ageing 42 (2013), 240–245.
    • (2013) Age Ageing , vol.42 , pp. 240-245
    • Bray, B.D.1    Campbell, J.2    Hoffman, A.3
  • 5
    • 70349245228 scopus 로고    scopus 로고
    • Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients
    • Derex, L., Nighoghossian, N., Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients. Nat Rev Neurol 5 (2009), 506–511.
    • (2009) Nat Rev Neurol , vol.5 , pp. 506-511
    • Derex, L.1    Nighoghossian, N.2
  • 6
    • 77952243849 scopus 로고    scopus 로고
    • Ischemic stroke in the elderly: an overview of evidence
    • Chen, R.L., Balami, J.S., Esiri, M.M., et al. Ischemic stroke in the elderly: an overview of evidence. Nat Rev Neurol 6 (2010), 2562–2565.
    • (2010) Nat Rev Neurol , vol.6 , pp. 2562-2565
    • Chen, R.L.1    Balami, J.S.2    Esiri, M.M.3
  • 7
    • 84858332645 scopus 로고    scopus 로고
    • Stroke in the very old: a systematic review of studies on incidence, outcome, and resource use
    • Russo, T., Felzani, G., Marini, C., Stroke in the very old: a systematic review of studies on incidence, outcome, and resource use. J Aging Res, 2011, 2011, 108785.
    • (2011) J Aging Res , vol.2011 , pp. 108785
    • Russo, T.1    Felzani, G.2    Marini, C.3
  • 8
    • 84982801696 scopus 로고    scopus 로고
    • Use and outcomes of intravenous thrombolysis for acute ischemic stroke in patients ≥90 years of age
    • Arora, R., Salamon, E., Katz, J.M., et al. Use and outcomes of intravenous thrombolysis for acute ischemic stroke in patients ≥90 years of age. Stroke 47 (2016), 2347–2354.
    • (2016) Stroke , vol.47 , pp. 2347-2354
    • Arora, R.1    Salamon, E.2    Katz, J.M.3
  • 9
    • 84924807350 scopus 로고    scopus 로고
    • Practice diversity among US stroke physicians with respect to the 3- to 4.5-h window
    • Mutgi, S.A., Behrouz, R., Practice diversity among US stroke physicians with respect to the 3- to 4.5-h window. Int J Stroke 10 (2015), E24–E25.
    • (2015) Int J Stroke , vol.10 , pp. E24-E25
    • Mutgi, S.A.1    Behrouz, R.2
  • 10
    • 77955171312 scopus 로고    scopus 로고
    • Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians
    • Mateen, F.J., Buchan, A.M., Hill, M.D., Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians. Stroke 41 (2010), 1833–1835.
    • (2010) Stroke , vol.41 , pp. 1833-1835
    • Mateen, F.J.1    Buchan, A.M.2    Hill, M.D.3
  • 11
    • 64749092071 scopus 로고    scopus 로고
    • Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older
    • Mateen, F.J., Nasser, M., Spencer, B.R., et al. Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older. Mayo Clin Proc 84 (2009), 334–338.
    • (2009) Mayo Clin Proc , vol.84 , pp. 334-338
    • Mateen, F.J.1    Nasser, M.2    Spencer, B.R.3
  • 12
    • 84938494941 scopus 로고    scopus 로고
    • Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians
    • Sun, M.C., Lai, T.B., Jeng, J.S., et al. Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians. Age Ageing 44 (2015), 158–161.
    • (2015) Age Ageing , vol.44 , pp. 158-161
    • Sun, M.C.1    Lai, T.B.2    Jeng, J.S.3
  • 13
    • 79960042510 scopus 로고    scopus 로고
    • Intravenous thrombolysis in nonagenarians with ischemic stroke
    • Sarikaya, H., Arnold, M., Engelter, S.T., et al. Intravenous thrombolysis in nonagenarians with ischemic stroke. Stroke 42 (2011), 1967–1970.
    • (2011) Stroke , vol.42 , pp. 1967-1970
    • Sarikaya, H.1    Arnold, M.2    Engelter, S.T.3
  • 14
    • 78149358574 scopus 로고    scopus 로고
    • Intravenous alteplase for stroke in those older than 80 years old
    • Ford, G.A., Ahmed, N., Azevedo, E., et al. Intravenous alteplase for stroke in those older than 80 years old. Stroke 41 (2010), 2568–2574.
    • (2010) Stroke , vol.41 , pp. 2568-2574
    • Ford, G.A.1    Ahmed, N.2    Azevedo, E.3
  • 15
    • 78649624539 scopus 로고    scopus 로고
    • Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive
    • Mishra, N.K., Ahmed, N., Andersen, G., et al. Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ, 341, 2010, c6046.
    • (2010) BMJ , vol.341 , pp. c6046
    • Mishra, N.K.1    Ahmed, N.2    Andersen, G.3
  • 16
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333 (1995), 1581–1587.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 17
    • 84862625338 scopus 로고    scopus 로고
    • The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the Third International Stroke Trial [IST-3]): a randomised controlled trial
    • Sandercock, P., Wardlaw, J.M., Lindley, R.I., et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the Third International Stroke Trial [IST-3]): a randomised controlled trial. Lancet 379 (2012), 2352–2363.
    • (2012) Lancet , vol.379 , pp. 2352-2363
    • Sandercock, P.1    Wardlaw, J.M.2    Lindley, R.I.3
  • 18
    • 84880326684 scopus 로고    scopus 로고
    • Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the Third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial
    • IST Collaborative Group. Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the Third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet Neurol 12 (2013), 768–776.
    • (2013) Lancet Neurol , vol.12 , pp. 768-776
  • 19
    • 0023866516 scopus 로고
    • The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration
    • WHO MONICA Project Principal Investigators, The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. J Clin Epidemiol 41 (1988), 105–114.
    • (1988) J Clin Epidemiol , vol.41 , pp. 105-114
    • WHO MONICA Project Principal Investigators1
  • 20
    • 33846347159 scopus 로고    scopus 로고
    • Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study
    • Wahlgren, N., Ahmed, N., Davalos, A., et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 369 (2007), 275–282.
    • (2007) Lancet , vol.369 , pp. 275-282
    • Wahlgren, N.1    Ahmed, N.2    Davalos, A.3
  • 21
    • 0035285349 scopus 로고    scopus 로고
    • Analyzing incomplete political science data: an alternative algorithm for multiple imputation
    • King, G., Honaker, J., Joseph, A., et al. Analyzing incomplete political science data: an alternative algorithm for multiple imputation. Am Polit Sci Rev 95 (2001), 49–69.
    • (2001) Am Polit Sci Rev , vol.95 , pp. 49-69
    • King, G.1    Honaker, J.2    Joseph, A.3
  • 22
    • 0003738155 scopus 로고
    • Multiple imputation for nonresponse in surveys
    • John Wiley & Sons New York
    • Rubin, D.B., Multiple imputation for nonresponse in surveys. 1987, John Wiley & Sons, New York.
    • (1987)
    • Rubin, D.B.1
  • 23
    • 0000001801 scopus 로고
    • The use of matched sampling and regression adjustment to remove bias in observational studies
    • Rubin, D.B., The use of matched sampling and regression adjustment to remove bias in observational studies. Biometrics 29 (1973), 185–203.
    • (1973) Biometrics , vol.29 , pp. 185-203
    • Rubin, D.B.1
  • 24
    • 79951916644 scopus 로고    scopus 로고
    • Causal inference without balance checking: Coarsened exact matching
    • [published online ahead of print August 23, 2011]. Political Analysis; Available at: (Accessed 25 April 2017)
    • Iacus, S.M., King, G., Porro, G., Causal inference without balance checking: Coarsened exact matching. [published online ahead of print August 23, 2011]. Political Analysis; Available at: http://pan.oxfordjournals.org/content/20/1/1.full, 2011. (Accessed 25 April 2017)
    • (2011)
    • Iacus, S.M.1    King, G.2    Porro, G.3
  • 25
    • 1542742319 scopus 로고    scopus 로고
    • Combining propensity score matching with additional adjustments for prognostic covariates
    • Rubin, D.B., Thomas, N., Combining propensity score matching with additional adjustments for prognostic covariates. J Am Stat Assoc 95 (2000), 573–585.
    • (2000) J Am Stat Assoc , vol.95 , pp. 573-585
    • Rubin, D.B.1    Thomas, N.2
  • 26
    • 34249885738 scopus 로고    scopus 로고
    • Matching as nonparametric preprocessing for reducing model dependence in parametric causal inference
    • Ho, D., Imai, K., King, G., et al. Matching as nonparametric preprocessing for reducing model dependence in parametric causal inference. Polit Anal 15 (2007), 199–236.
    • (2007) Polit Anal , vol.15 , pp. 199-236
    • Ho, D.1    Imai, K.2    King, G.3
  • 28
    • 84941175340 scopus 로고    scopus 로고
    • 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • Powers, W.J., Derdeyn, C.P., Biller, J., et al. 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 46 (2015), 3020–3035.
    • (2015) Stroke , vol.46 , pp. 3020-3035
    • Powers, W.J.1    Derdeyn, C.P.2    Biller, J.3
  • 29
    • 33644861844 scopus 로고    scopus 로고
    • Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients: an analysis of the nationwide inpatient sample 1999 to 2002
    • Bateman, B.T., Schumacher, H.C., Boden-Albala, B., et al. Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients: an analysis of the nationwide inpatient sample 1999 to 2002. Stroke 37 (2006), 440–446.
    • (2006) Stroke , vol.37 , pp. 440-446
    • Bateman, B.T.1    Schumacher, H.C.2    Boden-Albala, B.3
  • 30
    • 77649118940 scopus 로고    scopus 로고
    • Age-related differences in characteristics, performance measures, treatment trends, and outcomes in patients with ischemic stroke
    • Fonarow, G.C., Reeves, M.J., Zhao, X., et al. Age-related differences in characteristics, performance measures, treatment trends, and outcomes in patients with ischemic stroke. Circulation 121 (2010), 879–891.
    • (2010) Circulation , vol.121 , pp. 879-891
    • Fonarow, G.C.1    Reeves, M.J.2    Zhao, X.3
  • 31
    • 0032497292 scopus 로고    scopus 로고
    • Impact of atrial fibrillation on the risk of death: the Framingham Heart Study
    • Benjamin, E.J., Wolf, P.A., D'Agostino, R.B., et al. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 98 (1998), 946–952.
    • (1998) Circulation , vol.98 , pp. 946-952
    • Benjamin, E.J.1    Wolf, P.A.2    D'Agostino, R.B.3
  • 32
    • 84873641811 scopus 로고    scopus 로고
    • Factors influencing clinically meaningful recanalization after IV-rtPA in acute ischemic stroke
    • Murphy, A., Symons, S.P., Hopyan, J., et al. Factors influencing clinically meaningful recanalization after IV-rtPA in acute ischemic stroke. AJNR Am J Neuroradiol 34 (2013), 146–152.
    • (2013) AJNR Am J Neuroradiol , vol.34 , pp. 146-152
    • Murphy, A.1    Symons, S.P.2    Hopyan, J.3
  • 33
    • 85024481519 scopus 로고    scopus 로고
    • Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort
    • Khan, M.A., Baird, G.L., Miller, D., et al. Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort. J Neurointerv Surg, 2016, 10.1136/neurintsurg-2016-012427.
    • (2016) J Neurointerv Surg
    • Khan, M.A.1    Baird, G.L.2    Miller, D.3
  • 34
    • 0347986835 scopus 로고    scopus 로고
    • Age and National Institutes of Health Stroke Scale score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia. Development and external validation of prognostic models
    • Weimar, C., Konig, I.R., Kraywinkel, K., et al. Age and National Institutes of Health Stroke Scale score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia. Development and external validation of prognostic models. Stroke 35 (2004), 158–162.
    • (2004) Stroke , vol.35 , pp. 158-162
    • Weimar, C.1    Konig, I.R.2    Kraywinkel, K.3


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