Intravenous thrombolysis in nonagenarians with ischemic stroke

Stroke

Volumn 42, Issue 7, 2011, Pages 1967-1970

  Sarikaya, Hakan ^a   Arnold, Marcel ^b   Engelter, Stefan T ^c   Lyrer, Philippe A ^c   Michel, Patrik ^d   Odier, Céline ^d   Weder, Bruno ^e   Tettenborn, Barbara ^e   Mueller, Felix ^f   Sekoranja, Lucka ^g   Sztajzel, Roman ^g   Ballinari, Pietro ^h   Mattle, Heinrich P ^b   Baumgartner, Ralf W ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^f Kantonsspital Muensterlingen   (Switzerland)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^h UNIVERSITY OF BERN   (Switzerland)

Author keywords

ischemic stroke; nonagenarian; outcome; thrombolysis

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT;

AGED; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; STROKE; STROKE PATIENT; STROKE UNIT; SYSTOLIC BLOOD PRESSURE;

AGE FACTORS; AGED, 80 AND OVER; BLOOD PRESSURE; BRAIN ISCHEMIA; COHORT STUDIES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MULTIVARIATE ANALYSIS; STROKE; THROMBOLYTIC THERAPY; TREATMENT OUTCOME;

EID: 79960042510     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.601252     Document Type: Article

References (19)

1. Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE, Redgrave JN, Bull LM, Welch SJ, Cuthbertson FC, Binney LE, Gutnikov SA, Anslow P, Banning AP, Mant D, Mehta Z. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet. 2005; 366:1773-1783. (Pubitemid 41642641)
2. Heuschmann PU, Kolominsky-Rabas PL, Roether J, Misselwitz B, Lowitzsch K, Heidrich J, Hermanek P, Leffmann C, Sitzer M, Biegler M, Buecker-Nott HJ, Berger K. Predictors of in-hospital mortality in patients with acute ischemic stroke treated with thrombolytic therapy. JAMA. 2004;292:1831-1838. (Pubitemid 40169293)
3. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333:1581-1587.
4. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
5. Toni D, Lorenzano S, Agnelli G, Guidetti D, Orlandi G, Semplicini A, Toso V, Caso V, Malferrari G, Fanucchi S, Bartolomei L, Prencipe M. Intravenous thrombolysis with rt-PA in acute ischemic stroke patients aged older than 80 years in Italy. Cerebrovasc Dis. 2008;25:129-135. (Pubitemid 351280387)
6. Tanne D, Gorman MJ, Bates VE, Kasner SE, Scott P, Verro P, Binder JR, Dayno JM, Schultz LR, Levine SR. Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: The tPA stroke survey experience. Stroke. 2000;31:370-375. (Pubitemid 30078168)
7. Engelter ST, Reichhart M, Sekoranja L, Georgiadis D, Baumann A, Weder B, Muller F, Luthy R, Arnold M, Michel P, Mattle HP, Tettenborn B, Hungerbuhler HJ, Baumgartner RW, Sztajzel R, Bogousslavsky J, Lyrer PA. Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology. 2005;65:1795-1798.
8. International Year of Older Persons: Demographics of Older Persons. United Nations Department of Public Information web site. http://un.org/ NewLinks/older/99/older.htm. Accessed July 23, 2010.
9. Adams HP Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF. Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38: 1655-1711. (Pubitemid 46691097)
10. Engelter ST, Rutgers MP, Hatz F, Georgiadis D, Fluri F, Sekoranja L, Schwegler G, Muller F, Weder B, Sarikaya H, Luthy R, Arnold M, Nedeltchev K, Reichhart M, Mattle HP, Tettenborn B, Hungerbuhler HJ, Sztajzel R, Baumgartner RW, Michel P, Lyrer PA. Intravenous thrombolysis in stroke attributable to cervical artery dissection. Stroke. 2009;40:3772-3776.
11. Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): An observational study. Lancet. 2007; 369:275-282. (Pubitemid 46138121)
12. Mateen FJ, Nasser M, Spencer BR, Freeman WD, Shuaib A, Demaerschalk BM, Wijdicks EFM. Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older. Mayo Clin Proc. 2009;84:334-338.
13. Mateen FJ, Buchan AM, Hill MD; CASES Investigators. Outcomes of Thrombolysis for Acute Ischemic Stroke in Octogenarians Versus Nonagenarians. Stroke. 2010;41:1833-1835.
14. Ford GA, Ahmed N, Azevedo E, Grond M, Larrue V, Lindsberg PJ, Toni D, Wahlgren N. Intravenous alteplase for stroke in those older than 80 years old. Stroke. 2010;41:2568-2574.
15. van Oostenbrugge RJ, Hupperts RM, Lodder J. Thrombolysis for acute stroke with special emphasis on the very old: Experience from a single Dutch centre. J Neurol Neurosurg Psychiatry. 2006;77:375-377.
16. Kammersgaard LP, Jorgensen HS, Reith J, Nakayama H, Pedersen PM, Olsen TS. Short-and long-term prognosis for very old stroke patients. The copenhagen stroke study. Age Ageing. 2004;33:149-154. (Pubitemid 38313113)
17. Di Carlo A, Lamassa M, Pracucci G, Basile AM, Trefoloni G, Vanni P, Wolfe CD, Tilling K, Ebrahim S, Inzitari D. Stroke in the very old: Clinical presentation and determinants of 3-month functional outcome: A European perspective. European BIOMED Study of Stroke Care Group. Stroke. 1999;30:2313-2319. (Pubitemid 29517728)
18. Engelter ST, Bonati LH, Lyrer PA. Intravenous thrombolysis in stroke patients of versus years of age-a systematic review across cohort studies. Age Ageing. 2006;35:572-580. (Pubitemid 44614151)
19. Sandercock P, Lindley R, Wardlaw J, Dennis M, Lewis S, Venables G, Kobayashi A, Czlonkowska A, Berge E, Slot KB, Murray V, Peeters A, Hankey G, Matz K, Brainin M, Ricci S, Celani MG, Righetti E, Cantisani T, Gubitz G, Phillips S, Arauz A, Prasad K, Correia M, Lyrer P. Third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials. 2008;9-37.