Impact of INR monitoring, reversal agent use, heparin bridging, and anticoagulant interruption on rebleeding and thromboembolism in acute gastrointestinal bleeding

PLoS ONE

Volumn 12, Issue 9, 2017, Pages

  Nagata, Naoyoshi ^a   Sakurai, Toshiyuki ^a   Moriyasu, Shiori ^a   Shimbo, Takuro ^b   Okubo, Hidetaka ^a   Watanabe, Kazuhiro ^a   Yokoi, Chizu ^a   Yanase, Mikio ^a   Akiyama, Junichi ^a   Uemura, Naomi ^c  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b OHTA NISHINOUCHI HOSPITAL   (Japan)

^c National Center for Global Health and Medicine   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ANTICOAGULANT AGENT; HEPARIN; WARFARIN;

ACUTE GASTROINTESTINAL BLEEDING; AGED; ALBUMIN BLOOD LEVEL; ANTICOAGULANT THERAPY; ARTICLE; BLOOD TRANSFUSION; CLINICAL EVALUATION; COMORBIDITY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG USE; ENDOSCOPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT MONITORING; PATIENT SAFETY; RISK ASSESSMENT; SHOCK; THROMBOCYTE COUNT; THROMBOEMBOLISM; AGE; ATRIAL FIBRILLATION; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; MIDDLE AGED; RETROSPECTIVE STUDY; RISK FACTOR; TREATMENT OUTCOME;

AGE FACTORS; AGED; ANTICOAGULANTS; ATRIAL FIBRILLATION; COMORBIDITY; ENDOSCOPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEPARIN; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOEMBOLISM; TREATMENT OUTCOME; WARFARIN;

EID: 85029229477     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0183423     Document Type: Article

References (29)

1. Yamaguchi D, Sakata Y, Tsuruoka N, Shimoda R, Higuchi T, Sakata H, et al. Upper Gastrointestinal Bleeding in Japanese Patients Prescribed Antithrombotic Drugs: Differences in Trends over Time. Hepatogastroenterology. 2014; 61: 1055–1062. PMID: 26158165
2. ASGE Standards of Practice Committee, Acosta RD, Abraham NS, Chandrasekhara V, Chathadi KV, Early DS, et al. The management of antithrombotic agents for patients undergoing GI endoscopy. Gastrointest Endosc. 2016; 83: 3–16. https://doi.org/10.1016/j.gie.2015.09.035 PMID: 26621548
3. Veitch AM, Vanbiervliet G, Gershlick AH, Boustiere C, Baglin TP, Smith LA, et al. Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines. Gut. 2016; 65: 374–389. https://doi.org/10.1136/gutjnl-2015-311110 PMID: 26873868
4. Fujishiro M, Iguchi M, Kakushima N, Kato M, Sakata Y, Hoteya S, et al. Guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding. Dig Endosc. 2016; 28: 363–378. https://doi.org/10.1111/den.12639 PMID: 26900095
5. Choudari CP, Rajgopal C, Palmer KR. Acute gastrointestinal haemorrhage in anticoagulated patients: diagnoses and response to endoscopic treatment. Gut. 1994; 35: 464–466. PMID: 8174982
6. Thomopoulos KC, Mimidis KP, Theocharis GJ, Gatopoulou AG, Kartalis GN, Nikolopoulou VN. Acute upper gastrointestinal bleeding in patients on long-term oral anticoagulation therapy: endoscopic findings, clinical management and outcome. World J Gastroenterol. 2005; 11: 1365–1368. https://doi.org/10.3748/wjg.v11.i9.1365 PMID: 15761977
7. Radaelli F, Dentali F, Repici A, Amato A, Paggi S, Rondonotti E, et al. Management of anticoagulation in patients with acute gastrointestinal bleeding. Dig Liver Dis. 2015; 47: 621–627. https://doi.org/10.1016/j.dld.2015.03.029 PMID: 25935464
8. Wolf AT, Wasan SK, Saltzman JR. Impact of anticoagulation on rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage. Am J Gastroenterol. 2007; 102: 290–296.
9. Sengupta N, Feuerstein JD, Patwardhan VR, Tapper EB, Ketwaroo GA, Thaker AM, et al. The risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study. Am J Gastroenterol. 2015; 110: 328–335. https://doi.org/10.1038/ajg.2014.398 PMID: 25512338
10. Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, et al. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc. 2014; 26: 1–14.
11. Comerota AJ, Ramacciotti E. A Comprehensive Overview of Direct Oral Anticoagulants for the Management of Venous Thromboembolism. Am J Med Sci. 2016; 352: 92–106. https://doi.org/10.1016/j.amjms.2016.03.018 PMID: 27432042
12. Hernandez I, Baik SH, Pinera A, Zhang Y. Risk of bleeding with dabigatran in atrial fibrillation. JAMA Intern Med. 2015; 175: 18–24.
13. Holster IL, Valkhoff VE, Kuipers EJ, Tjwa ET. New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis. Gastroenterology. 2013; 145: 105–112.e15. https://doi.org/10.1053/j.gastro.2013.02.041 PMID: 23470618
14. Manatsathit W, Al-Hamid H, Leelasinjaroen P, Hashmi U, McCullough PA. Management of gastrointestinal bleeding in patients anticoagulated with dabigatran compared with warfarin: a retrospective, comparative case review. Cardiovasc Diagn Ther. 2014; 4: 224–231. https://doi.org/10.3978/j.issn.22233652.2014.03.07 PMID: 25009791
15. Nagata N, Sakurai T, Shimbo T, Moriyasu S, Okubo H, Watanabe K, et al. Acute Severe Gastrointestinal Tract Bleeding is Associated with an Increased Risk of Thromboembolism and Death. Clin Gastroenterol Hepatol. 2017 Jun 17. https://doi.org/10.1016/j.cgh.2017.06.028 PMID: 28634133
16. Nagata N, Niikura R, Sekine K, Sakurai T, Shimbo T, Kishida Y, et al. Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study. J Gastroenterol Hepatol. 2015; 30: 292–298. https://doi. org/10.1111/jgh.12805 PMID: 25339607
17. Nagata N, Niikura R, Aoki T, Shimbo T, Kishida Y, Sekine K, et al. Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy. Gastrointest Endosc. 2014. 2014; 80: 1124–31. https://doi.org/10.1016/j.gie.2014.06.039 PMID: 25088922
18. Tsuruoka N, Iwakiri R, Hara M, Shirahama N, Sakata Y, Miyahara K, et al. NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients: evaluation by a case-control study. J Gastroenterol Hepatol. 2011; 26: 1047–1052. https://doi.org/10.1111/j.1440-1746.2010.06610.x PMID: 21198829
19. Aoki T, Nagata N, Shimbo T, Niikura R, Sakurai T, Moriyasu S, et al. Development and Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding. Clin Gastroenterol Hepatol. 2016; 14: 1562–1570. https://doi.org/10.1016/j.cgh.2016.05.042 PMID: 27311620
20. Nagata N, Niikura R, Sakurai T, Shimbo T, Aoki T, Moriyasu S, et al. Safety and Effectiveness of Early Colonoscopy in Management of Acute Lower Gastrointestinal Bleeding on the Basis of Propensity Score Matching Analysis. Clin Gastroenterol Hepatol. 2016; 14: 558–564. https://doi.org/10.1016/j.cgh.2015.10.011 PMID: 26492844
21. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373–383. PMID: 3558716
22. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010; 137: 263–272. https://doi.org/10.1378/chest.09-1584 PMID: 19762550
23. Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010; 138: 1093–1100. https://doi.org/10.1378/chest.10-0134 PMID: 20299623
24. Ono K, Hidaka H, Koyama Y, Ishii K, Taguchi S, Kosaka M, et al. Effects of heparin bridging anticoagulation on perioperative bleeding and thromboembolic risks in patients undergoing abdominal malignancy surgery. J Anesth. 2016; 30: 723–726. https://doi.org/10.1007/s00540-016-2187-0 PMID: 27206420
25. Rubin TA, Murdoch M, Nelson DB. Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes. Gastrointest Endosc. 2003; 58: 369–373. PMID: 14528210
26. Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med. 1997; 126: 133–136. PMID: 9005747
27. Kearon C, Hirsh J. Management of anticoagulation before and after elective surgery. N Engl J Med. 1997; 336: 1506–1511. https://doi.org/10.1056/NEJM199705223362107 PMID: 9154771
28. Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JA, Dunn AS, et al. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation. N Engl J Med. 2015; 373: 823–833. https://doi.org/10.1056/NEJMoa1501035 PMID: 26095867
29. Yamaguchi D, Sakata Y, Tsuruoka N, Shimoda R, Higuchi T, Sakata H, et al. Characteristics of patients with non-variceal upper gastrointestinal bleeding taking antithrombotic agents. Dig Endosc. 2015; 27: 30–36.