Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells

Oncology Letters

Volumn 14, Issue 4, 2017, Pages 4391-4395

  Liu, Liang ^a   Zuo, Jing ^a   Wang, Guangda ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Epigallocatechin 3 gallate; Esophageal squamous cell carcinoma; Flow cytometry; Mitochondrial membrane potential

Indexed keywords

CASPASE 3; EPIGALLOCATECHIN GALLATE; TELOMERASE;

APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG MECHANISM; ENZYME ACTIVITY; ESOPHAGUS CARCINOMA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION;

EID: 85028941064     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2017.6712     Document Type: Article

References (27)

1. Gamliel Z: Incidence, epidemiology, and etiology of esophageal cancer. Chest Surg Clin N Am 10: 441-450, 2000.
2. Holmes RS and Vaughan TL: Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol 17: 2-9, 2007.
3. Wheeler JB and Reed CE: Epidemiology of esophageal cancer. Surg Clin North Am 92: 1077-1087, 2012.
4. Sugimura K, Miyata H, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori M and Doki Y: High infiltration of tumor-associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer. J Surg Oncol 111: 752-759, 2015.
5. Cao B, Shi Q and Wang W: Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin. J Thorac Dis 7: 711-719, 2015.
6. Liu L, Zuo LF, Zuo J and Wang J: Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo. Mol Med Rep 12: 1465-1472, 2015.
7. Yang GZ, Wang ZJ, Bai F, Qin XJ, Cao J, Lv JY and Zhang MS: Epigallocatechin-3-gallate protects HUVECs from PM2.5-induced oxidative stress injury by activating critical antioxidant pathways. Molecules 20: 6626-6639, 2015.
8. Zhao H, Xie P, Li X, Zhu W, Sun X, Sun X, Chen X, Xing L and Yu J: A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer. Radiother Oncol 114: 351-356, 2015.
9. Chen J, Xu J, Li J, Du L, Chen T, Liu P, Peng S, Wang M and Song H: Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress. Int Immunopharmacol 26: 147-152, 2015.
10. Shankar S, Ganapathy S and Srivastava RK: Green tea polyphenols: Biology and therapeutic implications in cancer. Front Biosci 12: 4881-4899, 2007.
11. Thangapazham RL, Singh AK, Sharma A, Warren J, GaddipatiJP and Maheshwari RK: Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo. Cancer Lett 245: 232-241, 2007.
12. Shin YS, Kang SU, Park JK, Kim YE, Kim YS, Baek SJ, Lee SH and Kim CH: Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin. Phytomedicine 23: 1344-1355, 2016.
13. Qiao Y, Cao J, Xie L and Shi X: Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells. Arch Pharm Res 32: 1309-1315, 2009.
14. Min NY, Kim JH, Choi JH, Liang W, Ko YJ, Rhee S, Bang H, Ham SW, Park AJ and Lee KH: Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate. Biochem Biophys Res Commun 421: 91-97, 2012.
15. Siddiqui WA, Ahad A and Ahsan H: The mystery of BCL2 family: Bcl-2 proteins and apoptosis: An update. Arch Toxicol 89: 289-317, 2015.
16. Aouacheria A, Cibiel A, Guillemin Y, Gillet G and Lalle P: Modulating mitochondria-mediated apoptotic cell death through targeting of Bcl-2 family proteins. Recent Pat DNA Gene Seq 1: 43-61, 2007.
17. Shi LS, Wang H, Wang F, Feng M, Wang M and Guan WX: Effects of gastrokine-2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. Mol Med Rep 10: 2898-2904, 2014.
18. Shi J, Liu F, Zhang W, Liu X, Lin B and Tang X: Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells. Oncol Rep 33: 2972-2980, 2015.
19. Irimie AI, Braicu C, Zanoaga O, Pileczki V, Gherman C, Berindan-Neagoe I and Campian RS: Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells. Onco Targets Ther 8: 461-470, 2015.
20. Tang G, Zhang Z, Qian H, Chen J, Wang Y, Chen X, Chen B and Chen Y: (-)-Epigallocatechin-3-gallate inhibits osteosarcoma cell invasiveness by inhibiting the MEK/ERK signaling pathway in human osteosarcoma cells. J Environ Pathol Toxicol Oncol 34: 85-93, 2015.
21. Bao H and Peng A: The green tea polyphenol(-)-epigallocatechin-3-gallate and its beneficial roles in chronic kidney disease. J Transl Int Med 4: 99-103, 2016.
22. Khan MA, Hussain A, Sundaram MK, Alalami U, Gunasekera D, Ramesh L, Hamza A and Quraishi U: (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol Rep 33: 1976-1984, 2015.
23. Wang J, Xie Y, Feng Y, Zhang L, Huang X, Shen X and Luo X: (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation. Int J Oncol 46: 1507-1515, 2015.
24. Li YJ, Wu SL, Lu SM, Chen F, Guo Y, Gan SM, Shi YL, Liu S and Li SL: (-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-κB p65 inactivation. Tumour Biol 36: 2747-2761, 2015.
25. Yang C, Du W and Yang D: Inhibition of green tea polyphenol EGCG ((-)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical wnt/β-catenin signalling pathway. Int J Food Sci Nutr 67: 818-827, 2016.
26. Shin YS, Kang SU, Park JK, Kim YE, Kim YS, Baek SJ, Lee SH and Kim CH: Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin. Phytomedicine 23: 1344-1355, 2016.
27. Li M, Li JJ, Gu QH, An J, Cao LM, Yang HP and Hu CP: EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncol Rep 35: 2339-2347, 2016.