Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression

Oncotarget

Volumn 8, Issue 37, 2017, Pages 60904-60916

  Mukherjee, Sumit ^a,b   Debata, Priya Ranjan ^a,e   Hussaini, Rahman ^a   Chatterjee, Kaushiki ^a,b   Baidoo, Juliet N E ^a,b   Sampat, Samay ^a   Szerszen, Anita ^c   Navarra, Joseph P ^d   Fata, Jimmie ^b   Severinova, Elena ^c,f   Banerjee, Probal ^a   Castellanos, Mario R ^c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c STATEN ISLAND UNIVERSITY HOSPITAL   (United States)

^d ST JOHN'S UNIVERSITY   (United States)

^e Maharaja Sriram Chandra Bhanja Deo University   (India)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

Cervical cancer; Combination index; Curcumin; Human papillomavirus; Synergism

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CURCUMIN; EPICATECHIN GALLATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN E6; PROTEIN P53; RAS PROTEIN; RESVERATROL; TRICURIN; UNCLASSIFIED DRUG;

A2780-TC1 CELL LINE; ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG SAFETY; ENZYME ACTIVATION; FEMALE; HELA CELL LINE; HUMAN PAPILLOMAVIRUS TYPE 18; IC50; MALE; MOUSE; NONHUMAN; OVARY ADENOCARCINOMA; PAPILLOMAVIRUS-TRANSFORMED CELL LINE; PROTEIN EXPRESSION; PROTEIN FOLDING; TOXICITY TESTING; UTERINE CERVIX CANCER; VIRUS CARCINOGENESIS; WART VIRUS;

EID: 85028745305     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16648     Document Type: Article

References (27)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61:69-90
2. Koutsky L. Epidemiology of genital human papillomavirus infection. Am J Med. 1997; 102:3-8
3. Fowler RS. Vulvar vestibulitis: response to hypocontactant vulvar therapy. J Low Genit Tract Dis. 2000; 4:200-203
4. Stanely M. Potential mechanisms for HPV vaccine-induced long-term protection. Gynec Oncol. 2010; 118:S2-7
5. Debata PR, Castellanos MR, Fata JE, Baggett S, Rajupet S, Szerszen A, Begum S, Mata A, Murty VV, Opitz LM, Banerjee P. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed himan cervical cancer cells. Gynec Oncol. 2013; 129:145-153
6. Langone P, Debata PR, Dolai S, Curcio GM, Inigo JD, Raja K, Banerjee P. Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin. Int J Cancer. 2012; 131:E569-E578
7. Langone P, Debata PR, Inigo Jdel R, Dolai S, Mukherjee SL, Halat P, Mastroianni K, Curcio GM, Castellanos MR, Raja K, Banerjee P. Coupling to a Glioblastoma-directed Antibody Potentiates Anti-tumor Activity of Curcumin. Int J Cancer. 2014; 135:710-719
8. Purkayastha S, Berliner A, Fernando SS, Ranasinghe B, Ray I, Tariq H, Banerjee P. Curcumin Blocks Brain Tumor Formation. Brain Res. 2009; 1266C:130-138
9. Shi W, Dolai S, Rizk S, Hussain A, Tariq H, Averick S, L'Amoreaux W, El-Idrissi A, Banerjee P, Raja K. Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications. Org Lett. 2007; 9:5461-5464
10. Ireson CR, Jones DJL, Orr S, Coughtrie MW, Boocock DJ, Williams ML, Farmer PB, Steward WP, Gescher AJ. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev. 2002; 11:105-111
11. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharmaceutics. 2007; 4:807-818
12. Yu Y, Deng Y, Lu, BM, Liu, YX, Li J, Bao JK. Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis. 2014; 19:1-18
13. Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ. Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr Rev. 2008; 66:445-454
14. Patel BB, Majumdar AP. Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview. Nutr Cancer. 2009; 61:842-846
15. Chou TC. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies. Pharmacol Rev. 2006; 58:621-681
16. Decrausaz L, Goncalves AR, Domingos-Pereira S, Pythoud C, Stehle JC, Schiller J, Jichlinski P, Nardelli-Haefliger D. A novel mucosal orthotopic murine model of human papillomavirus-associated genital cancers. Int J Cancer. 2011; 128:2105-2113
17. Gu W, Roeder RG. Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain. Cell. 1997; 90:595-606
18. Patel D, Huang S-M, Baglia LA, McCance DJ. The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300. EMBO J. 1999; 18:5061-5072
19. Sen GS, Mohanty S, Hossain DS, Bhattacharyya S, Banerjee S, Chakraborty J, Saha S, Ray P, Bhattacharjee P, Mandal D, Bhattacharya A, Chattopadhyay S, Das R, et al. Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFkB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer. J Biol Chem. 2011; 286:42232-42247
20. Talis AL, Huibregtse JM, Howley PM. The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells. J Biol Chem. 1998; 273:6439-6445
21. Maher DM, Bell MC, O'Donnell EA, Gupta BK, Jaggi M, Chauhan SC. Curcumin suppresses human papillomavirus oncoproteins, restores p53, rb, and ptpn13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol Carcinog. 2011; 50:47-57
22. Mishra A, Kumar R, Tyagi A, Kohaar I, Hedau S, Bharti AC, Sarker S, Dey D, Saluja D, Das B. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015; 9:525
23. Thomas M, Chiang CM. E6 Oncoprotein Represses p53-Dependent Gene Activation via Inhibition of Protein Acetylation Independently of Inducing p53 Degradation. Mol Cell. 2005; 17:252-264
24. Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, Stanley MA. The Biology and Life-Cycle of Human Papillomaviruses. Vaccine. 2012; 30S:F55-F70
25. Noehr B, Jensen A, Frederiksen K, Tabor A, Kjaer SK. Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period. Am J Obstet Gynecol. 2009; 201:33.e31-36
26. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 1998; 281:1677-1679
27. Xie X, Piao L, Bullock BN, Smith A, Su T, Zhang M, Teknos TN, Arora PS, Pan Q. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene. 2014; 33:1037-1046