Dose optimisation of intravenous tranexamic acid for elective hip and knee arthroplasty: The effectiveness of a single pre-operative dose

Bone and Joint Research

Volumn 6, Issue 8, 2017, Pages 499-505

  Morrison, R J M ^a   Tsang, B ^a   Fishley, W ^a   Harper, I ^a   Joseph, J C ^a   Reed, M R ^a  

^a NORTHUMBRIA HEALTHCARE NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Arthroplasty; Enhanced recovery; Hip; Knee; Tranexamic acid

Indexed keywords

TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; DEEP VEIN THROMBOSIS; DRUG DOSE INCREASE; ELECTIVE SURGERY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HIP ARTHROPLASTY; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; INCIDENCE; INTENSIVE CARE; LENGTH OF STAY; LUNG EMBOLISM; MALE; MORTALITY RATE; OPTIMAL DRUG DOSE; OUTCOME ASSESSMENT; PREOPERATIVE PERIOD; RETROSPECTIVE STUDY; SINGLE DRUG DOSE; SURGICAL MORTALITY; TOTAL HIP PROSTHESIS; TOTAL KNEE ARTHROPLASTY;

EID: 85028726011     PISSN: None     EISSN: 20463758     Source Type: Journal    
DOI: 10.1302/2046-3758.68.BJR-2017-0005.R1     Document Type: Article

References (27)

1. Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg 2002;183:630-641.
2. Malviya A, Martin K, Harper I, et al. Enhanced recovery program for hip and knee replacement reduces death rate. Acta Orthop 2011;82:577-581.
3. Pilbrant A, Schannong M, Vessman J. Pharmacokinetics and bioavailability of tranexamic acid. Eur J Clin Pharmacol 1981;20:65-72.
4. Ng W, Jerath A, Wąsowicz M. Tranexamic acid: a clinical review. Anaesthesiol Intensive Ther 2015;47:339-350.
5. Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg 2013;100:1271-1279.
6. Sukeik M, Alshryda S, Haddad FS, Mason JM. Systematic review and metaanalysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg [Br] 2011;93-B:39-46.
7. Rajesparan K, Biant LC, Ahmad M, Field RE. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg [Br] 2009;91-B:776-783.
8. Alshryda S, Sarda P, Sukeik M, et al. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg [Br] 2011;93-B:1577-1585.
9. Cid J, Lozano M. Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion 2005;45:1302-1307.
10. Poeran J, Rasul R, Suzuki S, et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014;349:g4829.
11. Irwin A, Khan SK, Jameson SS, et al. Oral versus intravenous tranexamic acid in enhanced-recovery primary total hip and knee replacement: results of 3000 procedures. Bone Joint J 2013;95-B:1556-1561.
12. Zohar E, Ellis M, Ifrach N, et al. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg 2004;99:1679-1683.
13. Alshryda S, Sukeik M, Sarda P, et al. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 2014;96-B:1005-1015.
14. Panteli M, Papakostidis C, Dahabreh Z, Giannoudis PV. Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis. Knee 2013;20: 300-309.
15. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054.
16. Hodgson S, Larvin JT, Dearman C. What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery? Interact Cardiovasc Thorac Surg 2015;21:384-388.
17. Jensen CD, Steval A, Partington PF, Reed MR, Muller SD. Return to theatre following total hip and knee replacement, before and after the introduction of rivaroxaban: a retrospective cohort study. J Bone Joint Surg [Br] 2011;93-B: 91-95.
18. World Health Organisation. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity, 2011. http://www.who.int/vmnis/indicators/haemoglobin/en (date last accessed 23 June 2017).
19. Madsen RV, Nielsen CS, Kallemose T, Husted H, Troelsen A. Low Risk of Thromboembolic Events After Routine Administration of Tranexamic Acid in Hip And Knee Arthroplasty. J Arthroplasty 2017;32:1298-1303.
20. Alshryda S, Mason JM, Sarda P, et al. The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study). J Orthop Traumatol 2015;16:27-34.
21. Nielsen CS, Jans Ø, Ørsnes T, et al. Combined intra-articular and intravenous tranexamic acid reduces blood loss in total knee arthroplasty: a randomized, doubleblind, placebo-controlled trial. J Bone Joint Surg [Am] 2016;98-A:835-841.
22. Hourlier H, Reina N, Fennema P. Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial. Arch Orthop Trauma Surg 2015;135:465-471.
23. Hourlier H, Fennema P. Single tranexamic acid dose to reduce perioperative morbidity in primary total hip replacement: a randomised clinical trial. Hip Int 2014;24:63-68.
24. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 2012;470:2605-2612.
25. Smit KM, Naudie DDR, Ralley FE, Berta DM, Howard JL. One dose of tranexamic acid is safe and effective in revision knee arthroplasty. J Arthroplasty 2013;28: 112-115.
26. Lin PC, Hsu CH, Huang CC, Chen WS, Wang JW. The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional preoperative injection effective? J Bone Joint Surg [Br] 2012;94-B:932-936.
27. Gibon E, Courpied JP, Hamadouche M. Total joint replacement and blood loss: what is the best equation? Int Orthop 2013;37:735-739.