One dose of tranexamic acid is safe and effective in revision knee arthroplasty

Journal of Arthroplasty

Volumn 28, Issue 8 SUPPL, 2013, Pages 112-115

  Smit, Kevin M ^a   Naudie, Douglas D R ^a   Ralley, Fiona E ^a   Berta, Donna M ^b   Howard, James L ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Blood loss; Revision knee arthroplasty; Tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID;

AGED; ARTICLE; BLOOD TRANSFUSION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIOPERATIVE HEMORRHAGE; PEROPERATIVE COMPLICATION; REOPERATION; RETROSPECTIVE STUDY; REVISION TOTAL KNEE ARTHROPLASTY; SURGICAL RISK; TOTAL KNEE REPLACEMENT;

BLOOD LOSS; REVISION KNEE ARTHROPLASTY; TRANEXAMIC ACID;

AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; REOPERATION; RETROSPECTIVE STUDIES; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84884132384     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2013.05.036     Document Type: Article

References (25)

1. Kurtz S., Ong K., Lau E., et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007, 89(4):780.
2. Evans S., O'Loughlin E., Bruce J. Retrospective audit of blood transfusion and comparison with haemoglobin concentration in patients undergoing elective primary and revision lower limb arthroplasty. Anaesth Intensive Care 2011, 39(3):480.
3. Dodd R.Y. The risk of transfusion-transmitted infection. N Engl J Med 1992, 327(6):419.
4. Neill F., Sear J.W., French G., et al. Increases in serum concentrations of cardiac proteins and the prediction of early postoperative cardiovascular complications in noncardiac surgery patients. Anaesthesia 2000, 55(7):641.
5. Cardone D., Klein A.A. Perioperative blood conservation. Eur J Anaesthesiol 2009, 26(9):722.
6. Zufferey P., Merquiol F., Laporte S., et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?. Anesthesiology 2006, 105(5):1034.
7. Astedt B. Clinical pharmacology of tranexamic acid. Scand J Gastroenterol Suppl 1987, 137:22.
8. Alshryda S., Sarda P., Sukeik M., et al. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br Vol 2011, 93(12):1577.
9. Zhang H, Chen J, Chen F, et al. The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA. 2011 Nov 8.
10. Yang Z.-G., Chen W.-P., Wu L.-D. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am 2012, 23:1.
11. Maniar RN, Kumar G, Singhi T, et al. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res. 2012 Mar 15.
12. Wong J., Abrishami A., El Beheiry H., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 2010, 92(15):2503.
13. Benoni G., Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 1996, 78(3):434.
14. Alvarez J.C., Santiveri F.X., Ramos I., et al. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 2008, 48(3):519.
15. Kakar P.N., Gupta N., Govil P., et al. Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesthesia 2009, 53(6):667.
16. Tanaka N., Sakahashi H., Sato E., et al. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 2001, 83(5):702.
17. Freedman J, Luke K, Monga N, et al. A provincial program of blood conservation: the Ontario Transfusion Coordinators (ONTraC). 2005;33:343.
18. Ralley F.E., Berta D., Binns V., et al. One intraoperative dose of tranexamic Acid for patients having primary hip or knee arthroplasty. Clin Orthop Relat Res 2010, 468(7):1905.
19. Bierbaum B.E., Callaghan J.J., Galante J.O., et al. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999, 81(1):2.
20. Cushner FD, Foley I, Kessler D, et al. Blood management in revision total knee arthroplasty. 2002;(404):247.
21. Aguilera X., Videla S., Almenara M., et al. Effectiveness of tranexamic acid in revision total knee arthroplasty. Acta Orthop Belg 2012, 78(1):68.
22. Hardeman F, Londers J, Favril A, et al. Predisposing factors which are relevant for the clinical outcome after revision total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2012 Jun;20(6):1049.
23. Pagnano M., Cushner F.D., Hansen A., et al. Blood management in two-stage revision knee arthroplasty for deep prosthetic infection. Clin Orthop Relat Res 1999, 238.
24. Oduwole K.O., Molony D.C., Walls R.J., et al. Increasing financial burden of revision total knee arthroplasty. Knee Surg, Sports Traumatol, Arthroscopy: Official J ESSKA 2010, 18(7):945.
25. Bozic K.J., Kurtz S.M., Lau E., et al. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 2010, 468(1):45.