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Volumn 73, Issue 5, 2018, Pages 727-735

Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer

Author keywords

Androgen receptor; AR V7; RNA in situ hybridization; Splice variant

Indexed keywords

ABIRATERONE; ANDROGEN RECEPTOR; ENZALUTAMIDE; PROSTATE SPECIFIC ANTIGEN; ANTIANDROGEN; ISOPROTEIN;

EID: 85028507741     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2017.08.009     Document Type: Article
Times cited : (52)

References (28)
  • 1
    • 84981738927 scopus 로고    scopus 로고
    • Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting
    • Antonarakis, E.S., Armstrong, A.J., Dehm, S.M., Luo, J., Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. Prostate Cancer Prostatic Dis 19 (2016), 231–241.
    • (2016) Prostate Cancer Prostatic Dis , vol.19 , pp. 231-241
    • Antonarakis, E.S.1    Armstrong, A.J.2    Dehm, S.M.3    Luo, J.4
  • 2
    • 84988645712 scopus 로고    scopus 로고
    • Targeting androgen receptor aberrations in castration-resistant prostate cancer
    • Sharp, A., Welti, J., Blagg, J., de Bono, J.S., Targeting androgen receptor aberrations in castration-resistant prostate cancer. Clin Cancer Res 22 (2016), 4280–4282.
    • (2016) Clin Cancer Res , vol.22 , pp. 4280-4282
    • Sharp, A.1    Welti, J.2    Blagg, J.3    de Bono, J.S.4
  • 3
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu, R., Dunn, T.A., Wei, S., et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69 (2009), 16–22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3
  • 4
    • 84925467074 scopus 로고    scopus 로고
    • Constitutively active AR-V7 plays an essential role in the development and progression of castration-resistant prostate cancer
    • Qu, Y., Dai, B., Ye, D., et al. Constitutively active AR-V7 plays an essential role in the development and progression of castration-resistant prostate cancer. Sci Rep, 5, 2015, 7654.
    • (2015) Sci Rep , vol.5 , pp. 7654
    • Qu, Y.1    Dai, B.2    Ye, D.3
  • 5
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hörnberg, E., Ylitalo, E.B., Crnalic, S., et al. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One, 6, 2011, e19059.
    • (2011) PLoS One , vol.6 , pp. e19059
    • Hörnberg, E.1    Ylitalo, E.B.2    Crnalic, S.3
  • 6
    • 84926160408 scopus 로고    scopus 로고
    • Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer
    • Efstathiou, E., Titus, M., Wen, S., et al. Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer. Eur Urol 67 (2015), 53–60.
    • (2015) Eur Urol , vol.67 , pp. 53-60
    • Efstathiou, E.1    Titus, M.2    Wen, S.3
  • 7
    • 84943380008 scopus 로고    scopus 로고
    • Detecting predictive androgen receptor modifications in circulating prostate cancer cells
    • Steinestel, J., Luedeke, M., Arndt, T., et al. Detecting predictive androgen receptor modifications in circulating prostate cancer cells. Oncotarget 23 (2015), 1–11.
    • (2015) Oncotarget , vol.23 , pp. 1-11
    • Steinestel, J.1    Luedeke, M.2    Arndt, T.3
  • 8
    • 84964588123 scopus 로고    scopus 로고
    • Analytical validation and clinical qualification of a new immunohistochemical assay for androgen receptor splice variant-7 protein expression in metastatic castration-resistant prostate cancer
    • Welti, J., Rodrigues, D.N., Sharp, A., et al. Analytical validation and clinical qualification of a new immunohistochemical assay for androgen receptor splice variant-7 protein expression in metastatic castration-resistant prostate cancer. Eur Urol 70 (2016), 599–608.
    • (2016) Eur Urol , vol.70 , pp. 599-608
    • Welti, J.1    Rodrigues, D.N.2    Sharp, A.3
  • 9
    • 85010711902 scopus 로고    scopus 로고
    • Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer
    • Antonarakis, E.S., Lu, C., Luber, B., et al. Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer. JAMA Oncol 1 (2015), 582–591.
    • (2015) JAMA Oncol , vol.1 , pp. 582-591
    • Antonarakis, E.S.1    Lu, C.2    Luber, B.3
  • 10
    • 84907057471 scopus 로고    scopus 로고
    • AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer
    • Antonarakis, E.S., Lu, C., Wang, H., et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med 371 (2014), 1028–1038.
    • (2014) N Engl J Med , vol.371 , pp. 1028-1038
    • Antonarakis, E.S.1    Lu, C.2    Wang, H.3
  • 11
    • 84983188883 scopus 로고    scopus 로고
    • Efficacy of cabazitaxel in castration-resistant prostate cancer is independent of the presence of AR-V7 in circulating tumor cells
    • Onstenk, W., Sieuwerts, A.M., Kraan, J., et al. Efficacy of cabazitaxel in castration-resistant prostate cancer is independent of the presence of AR-V7 in circulating tumor cells. Eur Urol 68 (2015), 939–945.
    • (2015) Eur Urol , vol.68 , pp. 939-945
    • Onstenk, W.1    Sieuwerts, A.M.2    Kraan, J.3
  • 12
    • 84994424610 scopus 로고    scopus 로고
    • The detection of androgen receptor splice variant 7 in plasma-derived exosomal RNA strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients
    • Del Re, M., Biasco, E., Crucitta, S., et al. The detection of androgen receptor splice variant 7 in plasma-derived exosomal RNA strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients. Eur Urol 71 (2017), 680–687.
    • (2017) Eur Urol , vol.71 , pp. 680-687
    • Del Re, M.1    Biasco, E.2    Crucitta, S.3
  • 13
    • 85012293401 scopus 로고    scopus 로고
    • Association of AR-V7 and prostate-specific antigen RNA levels in blood with efficacy of abiraterone acetate and enzalutamide treatment in men with prostate cancer
    • Qu, F., Xie, W., Nakabayashi, M., et al. Association of AR-V7 and prostate-specific antigen RNA levels in blood with efficacy of abiraterone acetate and enzalutamide treatment in men with prostate cancer. Clin Cancer Res 23 (2017), 726–734.
    • (2017) Clin Cancer Res , vol.23 , pp. 726-734
    • Qu, F.1    Xie, W.2    Nakabayashi, M.3
  • 14
    • 85003583757 scopus 로고    scopus 로고
    • AR-V7 transcripts in whole blood RNA of patients with metastatic castration resistant prostate cancer correlate with response to abiraterone acetate
    • Todenhofer, T., Azad, A., Stewart, C., et al. AR-V7 transcripts in whole blood RNA of patients with metastatic castration resistant prostate cancer correlate with response to abiraterone acetate. J Urol 197 (2017), 135–142.
    • (2017) J Urol , vol.197 , pp. 135-142
    • Todenhofer, T.1    Azad, A.2    Stewart, C.3
  • 15
    • 84995902323 scopus 로고    scopus 로고
    • v567es in patients with prostate cancer
    • v567es in patients with prostate cancer. J Urol 196 (2016), 1758–1763.
    • (2016) J Urol , vol.196 , pp. 1758-1763
    • Liu, X.1    Ledet, E.2    Li, D.3
  • 16
    • 84977633717 scopus 로고    scopus 로고
    • Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer
    • Luo, J., Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer. Asian J Androl 18 (2016), 580–585.
    • (2016) Asian J Androl , vol.18 , pp. 580-585
    • Luo, J.1
  • 17
    • 85006456753 scopus 로고    scopus 로고
    • Analytical validation of androgen receptor splice variant 7 detection in a Clinical Laboratory Improvement Amendments (CLIA) laboratory setting
    • Lokhandwala, P.M., Riel, S.L., Haley, L., et al. Analytical validation of androgen receptor splice variant 7 detection in a Clinical Laboratory Improvement Amendments (CLIA) laboratory setting. J Mol Diagn 19 (2017), 115–125.
    • (2017) J Mol Diagn , vol.19 , pp. 115-125
    • Lokhandwala, P.M.1    Riel, S.L.2    Haley, L.3
  • 18
    • 0042671348 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization: past, present and future
    • Levsky, J.M., Singer, R.H., Fluorescence in situ hybridization: past, present and future. J Cell Sci 116 (2003), 2833–2838.
    • (2003) J Cell Sci , vol.116 , pp. 2833-2838
    • Levsky, J.M.1    Singer, R.H.2
  • 19
    • 33745885289 scopus 로고    scopus 로고
    • Tyramide signal amplification for DNA and mRNA in situ hybridization
    • Speel, E.J., Hopman, A.H., Komminoth, P., Tyramide signal amplification for DNA and mRNA in situ hybridization. Methods Mol Biol 326 (2006), 33–60.
    • (2006) Methods Mol Biol , vol.326 , pp. 33-60
    • Speel, E.J.1    Hopman, A.H.2    Komminoth, P.3
  • 20
    • 84555189571 scopus 로고    scopus 로고
    • RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues
    • Wang, F., Flanagan, J., Su, N., et al. RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. J Mol Diagn 14 (2012), 22–29.
    • (2012) J Mol Diagn , vol.14 , pp. 22-29
    • Wang, F.1    Flanagan, J.2    Su, N.3
  • 21
    • 84991011417 scopus 로고    scopus 로고
    • Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer
    • Guedes, L.B., Morais, C.L., Almutairi, F., et al. Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer. Clin Cancer Res 22 (2016), 4651–4663.
    • (2016) Clin Cancer Res , vol.22 , pp. 4651-4663
    • Guedes, L.B.1    Morais, C.L.2    Almutairi, F.3
  • 22
    • 85010972345 scopus 로고    scopus 로고
    • Branched chain RNA in situ hybridization for androgen receptor splice variant AR-V7 as a prognostic biomarker for metastatic castration-sensitive prostate cancer
    • Saylor, P.J., Lee, R.J., Arora, K.S., et al. Branched chain RNA in situ hybridization for androgen receptor splice variant AR-V7 as a prognostic biomarker for metastatic castration-sensitive prostate cancer. Clin Cancer Res 23 (2017), 363–369.
    • (2017) Clin Cancer Res , vol.23 , pp. 363-369
    • Saylor, P.J.1    Lee, R.J.2    Arora, K.S.3
  • 23
    • 85028077218 scopus 로고    scopus 로고
    • Androgen receptor variant AR-V9 is co-expressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance
    • Kohli, M., Ho, Y., Hillman, D.W., et al. Androgen receptor variant AR-V9 is co-expressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance. Clin Cancer Res 23 (2017), 4704–4715.
    • (2017) Clin Cancer Res , vol.23 , pp. 4704-4715
    • Kohli, M.1    Ho, Y.2    Hillman, D.W.3
  • 24
    • 85013127577 scopus 로고    scopus 로고
    • Association of AR-V7 on circulating tumor cells as a treatment-specific biomarker with outcomes and survival in castration-resistant prostate cancer
    • Scher, H.I., Lu, D., Scgreiber, N.A., et al. Association of AR-V7 on circulating tumor cells as a treatment-specific biomarker with outcomes and survival in castration-resistant prostate cancer. JAMA Oncol 2 (2016), 1441–1449.
    • (2016) JAMA Oncol , vol.2 , pp. 1441-1449
    • Scher, H.I.1    Lu, D.2    Scgreiber, N.A.3
  • 25
    • 85019242735 scopus 로고    scopus 로고
    • Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide
    • Antonarakis, E.S., Lu, C., Luber, B., et al. Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide. J Clin Oncol 35 (2017), 2149–2156.
    • (2017) J Clin Oncol , vol.35 , pp. 2149-2156
    • Antonarakis, E.S.1    Lu, C.2    Luber, B.3
  • 26
    • 84930225081 scopus 로고    scopus 로고
    • Integrative clinical genomics of advanced prostate cancer
    • Robinson, D., Van Allen, E.M., Wu, Y.M., et al. Integrative clinical genomics of advanced prostate cancer. Cell 161 (2015), 1215–1228.
    • (2015) Cell , vol.161 , pp. 1215-1228
    • Robinson, D.1    Van Allen, E.M.2    Wu, Y.M.3
  • 27
    • 84959255550 scopus 로고    scopus 로고
    • Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
    • Kumar, A., Coleman, I., Morrissey, C., et al. Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer. Nat Med 22 (2016), 369–378.
    • (2016) Nat Med , vol.22 , pp. 369-378
    • Kumar, A.1    Coleman, I.2    Morrissey, C.3
  • 28
    • 84969627173 scopus 로고    scopus 로고
    • Second-generation HSP90 inhibitor onalespib blocks mRNA splicing of androgen receptor variant 7 in prostate cancer cells
    • Ferraldeschi, R., Welti, J., Powers, M.V., et al. Second-generation HSP90 inhibitor onalespib blocks mRNA splicing of androgen receptor variant 7 in prostate cancer cells. Cancer Res 76 (2016), 2731–2742.
    • (2016) Cancer Res , vol.76 , pp. 2731-2742
    • Ferraldeschi, R.1    Welti, J.2    Powers, M.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.