Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: The GENRA case-control study

Rheumatology (United Kingdom)

Volumn 56, Issue 8, 2017, Pages 1282-1292

  Traylor, Matthew ^a   Curtis, Charles ^a   Patel, Hamel ^a   Breen, Gerome ^a   Lee, Sang Hyuck ^a   Xu, Xiaohui ^a   Newhouse, Stephen ^a   Dobson, Richard ^a   Steer, Sophia ^b   Cope, Andrew P ^a   Markus, Hugh S ^c   Lewis, Cathryn M ^a   Scott, Ian C ^a,d,e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d HAYWOOD HOSPITAL   (United Kingdom)

^e KEELE UNIVERSITY   (United Kingdom)

Author keywords

African continental ancestry group; Arthritis; Genetic susceptibility; Rheumatoid; Smoking

Indexed keywords

ALCOHOL; EPITOPE; HLA ANTIGEN;

ADULT; AFRICAN CARIBBEAN; ALCOHOL CONSUMPTION; ARTICLE; BLACK PERSON; CASE CONTROL STUDY; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE ENVIRONMENT INTERACTION; GENOTYPING TECHNIQUE; HAPLOTYPE; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; UNITED KINGDOM; ADVERSE EFFECTS; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CAUCASIAN; DRINKING BEHAVIOR; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; ODDS RATIO; RISK FACTOR; STATISTICAL MODEL;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ALCOHOL DRINKING; ARTHRITIS, RHEUMATOID; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; EPITOPES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HLA ANTIGENS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; RISK FACTORS; SMOKING; UNITED KINGDOM;

EID: 85028327258     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kex048     Document Type: Article

References (34)

1. Scott IC, Steer S, Lewis CM, Cope AP. Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis. Best Pract Res Clin Rheumatol 2011;25:447-68.
2. Scott IC, Tan R, Stahl D et al. The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology 2013;52:856-67.
3. Sugiyama D, Nishimura K, Tamaki K et al. Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 2010;69:70-81.
4. Qin B, Yang M, Fu H et al. Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis. Arthritis Res Ther 2015;17:86.
5. Okada Y, Wu D, Trynka G et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014;506:376-81.
6. Scott IC, Seegobin SD, Steer S et al. Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking. PLoS Genet 2013;9:e1003808.
7. Malemba JJ, Mbuyi-Muamba JM, Mukaya J et al. The epidemiology of rheumatoid arthritis in Kinshasa, Democratic Republic of Congo-a population-based study. Rheumatology 2012;51:1644-7.
8. Viatte S, Flynn E, Lunt M et al. Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease. Arthritis Res Ther 2012;14:R239.
9. Singwe-Ngandeu M, Finckh A, Bas S, Tiercy JM, Gabay C. Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients. Arthritis Res Ther 2010;12:R36.
10. Dieye A, Diallo S, Diatta M et al. Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal. Dakar Med 1997;42:111-3.
11. Mikuls TR, Sayles H, Yu F et al. Associations of cigarette smoking with rheumatoid arthritis in African Americans. Arthritis Rheum 2010;62:3560-8.
12. von Elm E, Altman DG, Egger M et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453-7.
13. United Kingdom Clinical Research Network. Genetics Of Rheumatoid Arthritis In Individuals Of African Ancestry: the GENRA Study UK Clinical Research Network: Portfolio Database. http://public.ukcrn.org.uk/Search/StudyDetail. aspx?StudyID=11402 (6 September 2015, date last accessed).
14. Office for National Statistics. 2011 Census Questionnaire Content. http://webarchive.nationalarchives.gov.uk/20160105160709/http://ons.gov.uk/ons/guide-method/census/2011/how-our-census-works/how-we-tookthe-2011-census/how-we-collected-the-information/questionnaires-delivery-completion-and-return/index. html (20 March 2017, date last accessed).
15. Khan U, Crossley C, Kalra L et al. Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study. Stroke 2008;39:2943-9.
16. Genetic Analysis of Psoriasis Consortium, Wellcome Trust Case Control Consortium 2; Strange A, Capon F, Spencer CC et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010;42:985-90.
17. Scott IC, Rijsdijk F, Walker J et al. Do genetic susceptibility variants associate with disease severity in early active rheumatoid arthritis? J Rheumatol 2015;42:1131-40.
18. Illumina. Infinium Multi-Ethnic Global Beadchip: A Cost-Effective Array for Understanding Complex Disease in Diverse Human Populations 2016. https://www.illumina. com/content/dam/illumina-marketing/documents/products/-datasheets/multi-ethnic-global-data-sheet-370-2016-001. pdf (23 March 2017, date last accessed).
19. Price AL, Patterson NJ, Plenge RM et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-9.
20. Dilthey A, Leslie S, Moutsianas L et al. Multi-population classical HLA type imputation. PLoS Comput Biol 2013;9:e1002877.
21. Parkes M, Cortes A, van Heel DA, Brown MA. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 2013;14:661-73.
22. Raychaudhuri S, Sandor C, Stahl EA et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 2012;44:291-6.
23. Nagelkerke NJ. A note on a general definition of the coefficient of determination. Biometrika 1991;78:691-2.
24. Kallberg H, Padyukov L, Plenge RM et al. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 2007;80:867-75.
25. Rothman K, Greenland S. Modern epidemiology. Philadelphia, USA: Lippincott-Raven, 1998.
26. Gorman JD, Lum RF, Chen JJ et al. Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3, 240 rheumatoid arthritis patients. Arthritis Rheum 2004;50:400-12.
27. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19:149-50.
28. Cross-Disorder Group of the Psychiatric Genomics C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013;381:1371-9.
29. International Schizophrenia Consortium, Purcell SM, Wray NR et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009;460:748-52.
30. Viatte S, Plant D, Han B et al. Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response. JAMA 2015;313:1645-56.
31. Lambeth Council. Access to Mental Health Services for Black People in Lambeth. 2014. http://moderngov.lambeth. gov.uk/documents/s64809/10CCGAc cesstomentalhealthservicesforblackpeopleinLambethJan2014v1. docx.pdf (5 February 2016, date last accessed).
32. Council S. Southwark Demographic Factsheet. https://www.southwark.gov.uk/assets/attach/2653/Demographic%20factsheet.pdf (23 March 2017, date last accessed).
33. Li YR, Keating BJ. Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations. Genome Med 2014;6:91.
34. Traylor M, Lewis CM. Genetic discovery in multi-ethnic populations. Eur J Hum Genet 2016;24:1097-8.