Impact of Moringa oleifera lam. Leaf powder supplementation versus nutritional counseling on the body mass index and immune response of HIV patients on antiretroviral therapy: A single-blind randomized control trial

BMC Complementary and Alternative Medicine

Volumn 17, Issue 1, 2017, Pages

  Tshingani, Koy ^a,b   Donnen, Philippe ^c   Mukumbi, Henri ^d   Duez, Pierre ^e   Dramaix Wilmet, Michèle ^b  

^a Higher Institute of the Medical Techniques of Kinshasa (ISTM)   (Congo)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Centre de Recherche en Politique et Système de santé Santé Internationale   (Belgium)

^d ACS/AMO CONGO   (Congo)

^e UNIVERSITY OF MONS   (Belgium)

Author keywords

Antiretroviral therapy; Body mass index; CD4 count; DR Congo; HIV; Moringa oleifera; Supplementation

Indexed keywords

ANTIRETROVIRUS AGENT; PLANT EXTRACT;

ADOLESCENT; ADULT; BODY MASS; CD4 LYMPHOCYTE COUNT; CHEMISTRY; CONTROLLED STUDY; COUNSELING; DEMOCRATIC REPUBLIC CONGO; DIETARY SUPPLEMENT; FEMALE; HIV INFECTIONS; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; MORINGA OLEIFERA; PATHOPHYSIOLOGY; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-RETROVIRAL AGENTS; BODY MASS INDEX; CD4 LYMPHOCYTE COUNT; COUNSELING; DEMOCRATIC REPUBLIC OF THE CONGO; DIETARY SUPPLEMENTS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MORINGA OLEIFERA; PLANT EXTRACTS; PLANT LEAVES; YOUNG ADULT;

EID: 85027989935     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-017-1920-z     Document Type: Article

References (56)

1. ONUSIDA, AIDS by the numbers 2015. http://www.unaids.org/en/resources/documents/2015/AIDS_by_the_numbers_2015. Accessed 6 December 2016.
2. Esté JA, Cihlar T. Current status and challenges of antiretroviral research and therapy. Antivir Res. 2010;85:25-33. https://doi.org/10.1016/j.antiviral.2009.10.007.
3. Richman DD, Katlama C, Sekaly RP, Deeks SG, Autran B, Martinez-Picado J, et al. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet. 2013;381:2109-17.
4. Rigaud D. Nutrition et immunité. Service de Gastro-entérologie et Nutrition, Hôpital Bichat. Paris. http://www.institutdanone.org/objectif-nutrition/nutrition-et-immunite/dossier-nutrition-et-immunite. Accessed 10 May 2015
5. Wanke CA, Silva M, Knox TA, Forrester J, Speigelman D, Gorbach SL. Weight loss and wasting remain common complications in individuals infected with human immunodeficiency virus in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000;31:803-5.
6. Mangili A, Murman DH, Zampini AM, Wanke CA. Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort. Clin Infect Dis. 2006;42:836-42.
7. World Health Organization. Besoins en nutriments des personnes vivant avec le VIH/sida: rapport d'une consultation technique, Genève, 13-15 May 2003. http://www.who.int/nutrition/publications/hivaids/9789242591194_fre.pdf. Accessed 17 February 2015.
8. ème conférence internationale francophone VIH/hépatites, AFRAVIH, Montpellier 2014. https://www.ajspi.com/sites/default/files/club/programme_Final_AFRAVIH_2014_web.pdf. Accessed 10 February 2015.
9. Komiski L. Energy expenditure in HIV infection. Am J Clin Nutr 2011;94:1677S-82S, doi: https://doi.org/10.3945/ajcn.111.012625
10. World Health Organization, Food and Agriculture Organization of the United Nations. Living well with HIV/AIDS, a manual on nutritional care and support for people living with HIV/AIDS, Rome 2002. http://www.fao.org/3/a-y4168e.pdf. Accessed 17 January 2015.
11. World Food Program(WFP), the United Nations Program on HIV/AIDS (UNAIDS) and the U.S. President's Emergency Plan for AIDS Relief (PEPFAR): Nutrition assessment,counselling and support for adolescents and adults living with HIV. A programming guide: food and nutrition in the context of HIV and TB classification. Guide note 2014. http://documents.wfp.org/stellent/groups/public/documents/newsroom/wfp271543.pdf. Accessed Jan 2015.
12. World Health Organization. Essential prevention and care intervention for adults and adolescents living with HIV in ressource-limited settings. Geneva: World Health Organization, 2007. http://www.who.int/hiv/pub/plhiv/_treatment_care.pdf. Accessed 10 June 2015.
13. Programme National de Nutrition (Pronanut), politique nationale de nutrition, édition 2013. http://www.pronanut-rdc.org/qui-sommes-nous/2014-11-28-15-50-43.html. Accessed 16 Aug 2017.
14. Musumari PM, Wouters E, Kayembe PK, Kiumbu Nzita M, Mbikayi SM, Suguimoto SP, et al. Food insecurity is associated with increased risk of non-adherence to antiretroviral therapy among HIV-infected adults in the Democratic Republic of Congo: a cross-sectional study. PLoS One 2014;9:e85327, doi: https://doi.org/10.1371/journal.pone.0085327.
15. Tshingani K, Schirvel C, Mukumbi H, Ngambwe S, Wilmet-Dramaix M. Vulnerability factors for malnutrition among people living with HIV under antiretroviral treatment in an outpatient clinic: Kinshasa, Democratic Republic of Congo. HIV & AIDS Review 2013;12, doi: https://doi.org/10.1016/j.hivar.2013.11.001.
16. Tshingani K, Schirvel C, Mukumbi H, Wilmet-Dramaix M. L'évolution du poids des personnes vivant avec le VIH suivies sous antirétroviraux à Kinshasa, revue de l'U.KA. 2013:2.
17. TétéBénissan A, Quashie AML, Lawson K, Gnandi K, Kokou K, Gbéassor M. Influence of Moringa Oleifera leaves on atherogenic lipids and glycaemia evolution in HIV-infected and uninfected malnourished patients. J Appl Biosci. 2013;62:4610-9.
18. Coppin J. A study of the nutritional and medicinal values of Moringa oleifera leaves from sub-Saharan Africa: Ghana, Rwanda, Senegal and Zambia. M.Sc. thesis, Rutgers University-Graduate School-New Brunswick, New Brunswick. May 2008. https://doi.org/10.7282/T3MG7PVN. Accessed 8 Jan 2015.
19. Broin M. The nutritional value of Moringa oleifera Lam. Leaves: what can we learn from figures? Moringanews Workshop. 2006. http://www.moringanews.org/doc/GB/Posters/Broin_poster.pdf. Accessed 22 Feb 2015.
20. Moyo B, Masika PJ, Hugo A, Muchenje V. Nutritional characterization of Moringa (Moringa Oleifera lam.) leaves. Afr J Biotechnol. 2011;10:12925-33.
21. Fuglie LJ. The Miracle Tree: Moringa oleifera: natural nutrition for the tropics, (Church World Service, Dakar, 1999). pp: 68. Revised in 2001 and published as The Miracle Tree: The Multiple Attributes of Moringa, CTA, 2001. pp: 172.
22. Stohs SJ, Hartman MJ. Review of the safety and efficacy of Moringa Oleifera. Phytother Res 2015;29:796-804, doi: https://doi.org/10.1002/ptr.5325
23. Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP, Phivthong-Ngam L, et al. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa Oleifera lam. Leaves. J Ethnopharmacol 2008;116:439-46. doi: https://doi.org/10.1016/j.jep.2007.12.010
24. Jed W. Fahey. Moringa oleifera: A Review of the Medical Evidence for its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. TFLJ. 2005;1:5. http://www.tfljournal.org/article.php/20051201124931586. Accessible 12 Jan 2015.
25. Anselme Nkinsi, les feuilles de Moringa sauvent des vies. http://ipsinternational.org/fr_note.asp?idnews=7050. Accessed 15 July 2014.
26. World Medical Association. Declaration of Helsinki. 2008. https://www.wma.net/fr/policies-post/declaration-dhelsinki-de-lamm-principes-ethiques-applicables-a-la-recherche-medicale-impliquant-des-etres-humains/. Accessed 16 Aug 2017.
27. WHO 2010. Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2010, 27-29. http://www.who.int/hiv/pub/arv/adult2010/en/. Accessed 20 July 2014.
28. Tandu-Umba NFB. Nutrition de la théorie à la pratique, presses de l'Université de Kinshasa. 2001.
29. Muteba Kalala D, Ntoto R, Lebailly P. Comportement et pratiques alimentaires à Kinshasa. Une approche basée sur le rapprochement des conditions de vie et des modes de consommation alimentaires des ménages. Communication présentée aux 7èmes Journées de Recherches en Sciences Sociales, Session D.4 - Risques - amphi La Quintinie, Angers, France, 2013.
30. Rinehart W, Rudy S, Drennan M. GATHER guide to counseling. Popul Rep J. 1998;48:1-31.
31. Brayton SV. Acid digestions using the Hach Digesdahl digestion apparatus, sample preparation for protein and elemental analysis, technical information series booklet no.14. http://www.hach.com/digesdahl-digestion-apparatus-115-vac/product-downloads?id=7640450051. Accessed 12 July 2012.
32. Ichihara K, Fukubayashi Y. Preparation of fatty acid methyl esters for gas-liquid chromatography. J Lipid Res 2010;51:635-40. doi: https://doi.org/10.1194/jlr.D001065.
33. Council of Europe, "2-4-23, Sterols in fatty oils", in: European Pharmacopoeia 8th edn., Council of Europe, Strasbourg, 2013.
34. Emlet CA. 'You're awfully old to have this disease': experiences of stigma and ageism in adults 50 years and older living with HIV/AIDS. Gerontologist. 2006;46:781-90.
35. Scarcella P, Buonomo E, Zimba I, Doro Altan AM, Germano P, Palombi L, et al. The impact of integrating food supplementation, nutritional education and HAART (highly active antiretroviral therapy) on the nutritional status of patients living with HIV/AIDS in Mozambique: results from the DREAM Programme. Ig Sanita Pubbl. 2011;67:41-52.
36. Guide national de traitement de l'infection à VIH par les antirétroviraux Version révisée avec l'appui de l'OMS et de l'ONUSIDA, PNLS, janvier 2005. http://www.who.int/hiv/pub/guidelines/drc_art.pdf. Accessed 15 December 2014.
37. Grobler L,Siegfried N,Visser ME,Mahlungulu SSN,Volmink J.Nutritional interventions for reducing morbidity and mortality in people with HIV.Cochrane Database Syst Rev.2013;(2). Art. No.: CD004536. doi: 10.1002/14651858.CD004536.pub3. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004536.pub3/full.
38. Koethe JR, Lukusa A, Giganti MJ, Chi BH, Nyirenda CK, Limbada MI, et al. Association between weight gain and clinical outcomes among malnourished adults initiating antiretroviral therapy in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2010;53:507-13.
39. Ndong M, Wade S, Dossou N, Guiro TA, Gning RD. Valeur nutritionnelle du Moringa oleifera, étude de la biodisponibilité du Fer, effet de l'enrichissement de divers plats traditionnels sénégalais avec la poudre des Afr. J Food Agric Nutr Dev. 2007;7
40. Tete-Benissan A, Quashie M, Lawsonevi K, Kokou K, Gbeassor M. Récupération nutritionnelle chez les sujets malnutris VIH positifs et VIH négatifs après utilisation de feuilles de Moringa oleifera Lam. J Anim Plant Sci. 2012;15:2184-99.
41. Teixeira EM, Carvalho MR, Neves VA, Silva MA, Arantes-Pereira L. Chemical characteristics and fractionation of proteins from Moringa Oleifera lam. Leaves Food Chem 2014;147:51-4. doi: https://doi.org/10.1016/j.foodchem.2013.09.135.
42. Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr. 1999;70(Suppl 3):491-9.
43. Mallillin AC, Trinidad TP, Sagum RS, de Leon MP, Borlagdan MP, Baquiran AFP, et al. Mineral availability and dietary fiber characteristics of Moringa Oleifera. Food Public Health 2014;4:242-6, doi: 10.5923/j.fph. 20140405.05.
44. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa Oleifera: a food plant with multiple medicinal uses. Phytother Res. 2007;21:17-25.
45. Thurber MD, Fahey JW. Adoption of Moringa Oleifera to combat under-nutrition viewed through the lens of the "diffusion of innovations" theory. Ecol Food Nutr 2009;48:212-25, doi: https://doi.org/10.1080/03670240902794598.
46. Ferrando SJ, Rabkin JG, Lin SH, McElhiney M. Increase in body cell mass and decrease in wasting are associated with increasing potency of antiretroviral therapy for HIV infection. AIDS Patient Care. 2005;19:216-23.
47. Williams SB, Bartsch G, Muurahainen N, Collins G, Raghavan SS, Wheeler D. Protein intake is positively associated with body cell mass in weight-stable HIV-infected men. J Nutr. 2003;133:1143-6.
48. Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr. 2006;84:475-82.
49. Houtzager LM. Nutrition in HIV: a review. J Postgrad Med. 2009;11:63-75.
50. Räsänen M, Niinikoski H, Keskinen S, Heino T, Lagström H, Simell O, et al. Impact of nutrition counselling on nutrition knowledge and nutrient intake of 7- to 9-y-old children in an atherosclerosis prevention project. Eur J Clin Nutr. 2004;58:162-72.
51. Derose KP, Felician M, Han B, Palar K, Ramírez B, Farías H, et al. A pre-post pilot study of peer nutritional counseling and food insecurity and nutritional outcomes among antiretroviral therapy patients in Honduras. BMC Nutrition 2015;1:21, doi: 10.1186/s40795 - 015 - 0017-7.
52. King AJ, Levey AS. Dietary protein and renal function. J Am Soc Nephrol. 1993;3:1723-37.
53. Nakamura H, Ito S, Ebe N, Shibata A. Renal effects of different types of protein in healthy volunteer subjects and diabetic patients. Diabetes Care. 1993;16:1071-5.
54. Kalayjian RC. The treatment of HIV-associated nephropathy, adv. Chronic Kidney Dis. 2010;17:59-71.
55. Winston J, Deray G, Hawkins T, Szczech L, Wyatt C, Young B. Kidney disease in patients with HIV infection and AIDS. Clin Infect Dis. 2008;47:1449-57.
56. Calza L. Renal toxicity associated with antiretroviral therapy. HIV Clin trials. 2012;13:189-211.