Association between weight gain and clinical outcomes among malnourished adults initiating antiretroviral therapy in Lusaka, Zambia

Journal of Acquired Immune Deficiency Syndromes

Volumn 53, Issue 4, 2010, Pages 507-513

  Koethe, John R ^a,b   Lukusa, Anna ^a   Giganti, Mark J ^a   Chi, Benjamin H ^a,c   Nyirenda, Christopher K ^d   Limbada, Mohammed I ^a   Banda, Yolan ^a   Stringer, Jeffrey S A ^a,c  

^a CENTRE FOR INFECTIOUS DISEASE RESEARCH IN ZAMBIA   (Zambia)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY TEACHING HOSPITAL   (Zambia)

Author keywords

Africa; Antiretroviral therapy; Body mass index; Epidemiology; HIV; Nutrition

Indexed keywords

EFAVIRENZ; EMTRICITABINE; LAMIVUDINE; NEVIRAPINE; STAVUDINE; TENOFOVIR; ZIDOVUDINE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURVIVAL; TREATMENT FAILURE; WEIGHT GAIN; WEIGHT REDUCTION; ZAMBIA;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MALNUTRITION; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME; WEIGHT GAIN; ZAMBIA;

EID: 77949347626     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181b32baf     Document Type: Article

References (35)

1. World Health Organisation Joint United Nations Programme on HIV/ AIDS United Nations Children's Fund. Towards Universal Access: Scaling up Priority HIV/AIDS Interventions in the Health Sector: Progress Report 2008. Geneva, Switzerland: WHO 2008.
2. Coetzee D, Hildebrand K, Boulle A, et al. Outcomes after two years of providing antiretroviral treatment in Khayelitsha South Africa. AIDS 2004; 18: 887-895.
3. Stringer JS, Zulu I, Levy J, et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA. 2006; 296:782-793.
4. Bussmann H, Wester CW, Ndwapi N, et al. Five-year outcomes of initial patients treated in Botswana's National Antiretroviral Treatment Program. AIDS. 2008;22:2303-2311.
5. Nash D, Katyal M, Brinkhof MW, et al. Long-term immunologic response to antiretroviral therapy in low-income countries: a collaborative analysis of prospective studies. AIDS. 2008;22:2291-2302.
6. Food and Agriculture Organization of the United Nations. The State of Food Insecurity in the World. Rome, Italy: FAO; 2003. Also available at: http://www.fao.org/docrep/006/j0083e/j0083e00.htm. Accessed August 31 2009.
7. United Nations, Administrative Committee on Coordination, SubCommittee on Nutrition. Fourth Report on the World Nutrition Situation. Geneva, Switzerland: United Nations ACC/SCN 2000.
8. Zachariah R, Fitzgerald M, Massaquoi M, et al. Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. AIDS. 2006;20:2355-2360.
9. Johannessen A, Naman E, Ngowi BJ, et al. Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania. BMC Infect Dis. 2008;8:52.
10. Marston B, De Cock KM. Multivitamins, nutrition, and antiretroviral therapy for HIV disease in Africa. N Engl J Med. 2004;351:78-80.
11. Piwoz E. Nutrition and HIV/AIDS: Evidence, Gaps, and Priority Actions. Washington, DC: Academy for Educational Development [AED], Support for Analysis and Research in Africa [SARA]. 2004.
12. Bolton-Moore C, Mubiana-Mbewe M, Cantrell RA, et al. Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia. JAMA. 2007;298: 1888-1899.
13. Cantrell RA, Sinkala M, Megazinni K, et al. A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2008;49:190-195.
14. Goldman JD, Cantrell RA, Mulenga LB, et al. Simple adherence assessments to predict virologic failure among HIV-infected adults with discordant immunologic and clinical responses to antiretroviral therapy. AIDS Res Hum Retroviruses. 2008;24:1031-1035.
15. Centers for Disease Control and Prevention. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases. MMWR Morb Mortal Wkly Rep 1987; 36(Suppl 1): 1S-15S.
16. Kotler DP, Tierney AR, Wang J, et al. Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS. Am J Clin Nutr. 1989;50:444-447.
17. Wheeler DA, Gibert CL, Launer CA, et al. Weight loss as a predictor of survival and disease progression in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;18:80-85.
18. Kotler DP, Rosenbaum K, Wang J, et al. Studies of body composition and fat distribution in HIV-infected and control subjects. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20:228-237.
19. Kotler DP, Wang J, Pierson RN. Body composition studies in patients with the acquired immunodeficiency syndrome. Am J Clin Nutr. 1985;42: 1255-1265.
20. Nguyen A, Calmy A, Schiffer V, et al. Lipodystrophy and weight changes: data from the Swiss HIV Cohort Study, 2000-2006. HIV Med. 2008;9: 142-150.
21. Kosmiski LA, Miller HL, Klemm DJ. In combination, nucleoside reverse transcriptase inhibitors have significant effects on 3T3-L1 adipocyte lipid accumulation and survival. Antivir Ther. 2006;11: 187-195.
22. Seminari E, Tinelli C, Minoli L, et al. Evaluation of the risk factors associated with lipodystrophy development in a cohort of HIV-positive patients. Antivir Ther. 2002;7:175-180.
23. Williams SB, Bartsch G, Muurahainen N, et al. Protein intake is positively associated with body cell mass in weight-stable HIV-infected men. JNutr. 2003;133:1143-1146
24. United States Agency for International Development. Food Commodity Fact Sheets. Available at http://www.usaid.gov/our-work/humanitarian-assistance/ffp/ crg/sec2.htm. Updated January 2006. Accessed August 31, 2009.
25. Mahlungulu S, Grobler LA, Visser ME, et al. Nutritional interventions for reducing morbidity and mortality in people with HIV Cochrane Database Syst Rev. 2007;(3):CD004536.
26. Hardon AP, Akurut D, Comoro C, et al. Hunger, waiting time and transport costs: time to confront challenges to ART adherence in Africa. AIDS Care. 2007;19:658-665.
27. Au JT, Kayitenkore K, Shutes E, et al. Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda. AIDS. 2006;20:2116-2118.
28. Ammassari A, Murri R, Pezzotti P, et al. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr. 2001;28:445-449.
29. World Health Organisation. Scaling up Antiretroviral Therapy in Resource-Limited Settings: Treatment Guidelines for a Public Health Approach. Geneva, Switzerland: WHO; 2003.
30. Nash D. Characteristics of Facilities and Programs Delivering HIV Care and Treatment Services Are Associated with Loss to Follow-up Rates in Programs from 7 Sub-Saharan African Countries. Presented at: 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, MA.
31. The United States President's Emergency Plan for AIDS Relief. Emergency Plan Policy Change in Food and Nutrition Programming. Available at: http://www.pepfar.gov/documents/organization/98940.pdf. Accessed August 31, 2009.
32. The United States President's Emergency Plan for AIDS Relief. Policy Guidance on the Use of Emergency Plan Funds to Address Food and Nutrition Needs. Available at: http://www.pepfar.gov/pepfar/guidance/77980.htm. 2006. Accessed August 31, 2009.
33. Mamlin J, Kimaiyo S, Lewis S, et al. Integrating nutrition support for food-insecure patients and their dependents into an HIV care and treatment program in Western Kenya. Am J Public Health. 2009;99:215-221.
34. Dibari FA Qualitative Investigation of Plumpynuf Consumption and Access in Adults enrolled in an MoH/MSF HIV Programme in Kenya. Presented at: the 2008 MSF Scientific Day; June 5 2008; London, UK.
35. Bowie C, Kalilani L, Marsh R, et al. An assessment of food supplementation to chronically sick patients receiving home based care in Bangwe, Malawi: a descriptive study. Nutr J. 2005;4:12.