Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

Virology Journal

Volumn 14, Issue 1, 2017, Pages

  McAuley, Julie ^a   Deng, Yi Mo ^b   Gilbertson, Brad ^a   Mackenzie Kludas, Charley ^a   Barr, Ian ^b   Brown, Lorena ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b PETER DOHERTY INSTITUTE FOR INFECTION AND IMMUNITY   (Australia)

Author keywords

Inflammation; Influenza A virus; Pandemic; Pathogenicity; PB1 F2; Respiratory disease; Seasonal; Virulence

Indexed keywords

UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRAL PROTEIN PB1 F2; VIRUS RNA; CYTOKINE; PB1-F2 PROTEIN, INFLUENZA A VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; INFLAMMATION; INFLUENZA; INFLUENZA A VIRUS (H3N2); LUNG INFILTRATE; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; PB1 GENE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; VIRUS GENE; VIRUS LOAD; ANIMAL; AVIAN INFLUENZA; BAGG ALBINO MOUSE; BIRD; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; LUNG LAVAGE; METABOLISM; NUCLEOTIDE SEQUENCE; ORTHOMYXOVIRUS INFECTION; PANDEMIC; PATHOGENICITY; SEASON; SEQUENCE ANALYSIS; VIROLOGY; VIRULENCE;

ANIMALS; BASE SEQUENCE; BIRDS; BRONCHOALVEOLAR LAVAGE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; SEASONS; SEQUENCE ANALYSIS; VIRAL LOAD; VIRAL PROTEINS; VIRULENCE;

EID: 85027977569     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-017-0827-0     Document Type: Article

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