Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors

Microbial Pathogenesis

Volumn 111, Issue , 2017, Pages 99-107

  Kalaiarasan, Ellappan ^a   Thirumalaswamy, Kottha ^b   Harish, Belgode Narasimha ^a   Gnanasambandam, Vasuki ^b   Sali, Veeresh Kumar ^b   John, James ^b  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b PONDICHERRY UNIVERSITY   (India)

Author keywords

Biofilm; CABHL; FABHL; LasR; Pseudomonas aeruginosa; Quorum sensing

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM ISOLATE; BIOFILM; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; LASR GENE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; QUORUM SENSING; REAL TIME POLYMERASE CHAIN REACTION; RHLR GENE; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR DOCKING; MOLECULAR MODEL; MONONUCLEAR CELL; PHYSIOLOGY;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; GAMMA BUTYROLACTONE; HOMOSERINE LACTONE; LASR PROTEIN, PSEUDOMONAS AERUGINOSA; RHLR PROTEIN, PSEUDOMONAS AERUGINOSA; TRANSACTIVATOR PROTEIN; VIRULENCE FACTOR;

4-BUTYROLACTONE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOFILMS; CELL SURVIVAL; DOWN-REGULATION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; LEUKOCYTES, MONONUCLEAR; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; TRANS-ACTIVATORS; VIRULENCE FACTORS;

EID: 85027963727     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2017.08.017     Document Type: Article

References (28)

1. Lyczaka, J.B., Cannon, C.L., Pier, G.B., Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microb. Infect., 2, 2000, 1051.
2. Hentzer, M., Wu, H., Andersen, J.B., Riedel, K., Rasmussen, T.B., Bagge, N., Kumar, N., Schembri, M.A., Song, Z., Kristoffersen, P., Manefield, M., Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J., 22, 2003, 3803.
3. Antunes, L.C.M., Ferreira, R.B., Buckner, M.M., Finlay, B.B., Quorum sensing in bacterial virulence. Microbiology, 156, 2010, 2271.
4. Ng, W.L., Bassler, B.L., Bacterial quorum-sensing network architectures. Annu. Rev. Genet., 43, 2009, 197.
5. Rutherford, S.T., Bassler, B.L., Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb. Perspect. Med., 2, 2012, a012427.
6. Zhu, J., Winans, S.C., Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells. Proc. Natl. Acad. Sci. U. S. A., 96, 1999, 4832.
7. Zhu, J., Winans, S.C., The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization. Proc. Natl. Acad. Sci. U. S. A., 98, 2001, 1507.
8. Pesci, E.C., Pearson, J.P., Seed, P.C., Iglewski, B.H., Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. 1997 J. Bacteriol., 179, 1997, 3127.
9. Schuster, M., Lostroh, C.P., Ogi, T., Greenberg, E.P., Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol., 185, 2003, 2066.
10. Tan, M.W., Rahme, L.G., Sternberg, J.A., Tompkins, R.G., Ausubel, F.M., Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proc. Natl. Acad. Sci. U. S. A., 96, 1999, 2408.
11. O'Loughlin, C.T., Miller, L.C., Siryaporn, A., Drescher, K., Semmelhack, M.F., Bassler, B.L., A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc. Natl. Acad. Sci. U. S. A., 110, 2013, 17981.
12. Wagner, V.E., Bushnell, D., Passador, L., Brooks, A.I., Iglewski, B.H., Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol., 185, 2003, 2080.
13. Parsek, M.R., Greenberg, E.P., Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc. Natl. Acad. Sci. U. S. A., 97, 2000, 8789.
14. Baechler, E.C., Batliwalla, F.M., Karypis, G., Gaffney, P.M., Ortmann, W.A., Espe, K.J., Shark, K.B., Grande, W.J., Hughes, K.M., Kapur, V., Gregersen, P.K., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc. Natl. Acad. Sci. U. S. A., 100, 2003, 2610.
15. Molaae, N., Mosayebi, G., Pishdadian, A., Ejtehadifar, M., Ganji, A., Evaluating the proliferation of human peripheral blood mononuclear cells using MTT assay. Int. J. Basic Sci. Med. 2:1 (2017), 25–28.
16. Lun, S., Guo, H., Onajole, O.K., Pieroni, M., Gunosewoyo, H., Chen, G., Tipparaju, S.K., Ammerman, N.C., Kozikowski, A.P., Bishai, W.R., Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat. Commun., 19, 2013, 4.
17. Venugopala, K.N., Krishnappa, M., Nayak, S.K., Subrahmanya, B.K., Vaderapura, J.P., Chalannavar, R.K., Gleiser, R.M., Odhav, B., Synthesis and antimosquito properties of 2, 6-substituted benzo [d] thiazole and 2, 4-substituted benzo [d] thiazole analogues against Anopheles arabiensis. Eur. J. Med. Chem. 31 (2013), 295–303.
18. Morris, G.M., Goodsell, D.S., Halliday, R.S., Huey, R., Hart, W.E., Belew, R.K., Olson, A.J., Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J. Comput. Chem. 19 (1998), 1639–1662.
19. Sathishkumar, N., Sathiyamoorthy, S., Ramya, M., Yang, D.U., Lee, H.N., Yang, D.C., Molecular docking studies of anti-apoptotic BCL-2, BCL-XL, and MCL-1 proteins with ginsenosides from Panax ginseng. J. Enzyme Inhib. Med. Chem. 27 (2012), 685–692.
20. Shafi, S., Alam, M.M., Mulakayala, N., Mulakayala, C., Vanaja, G., Kalle, A.M., Pallu, R., Alam, M.S., Synthesis of novel 2-mercapto benzothiazole and 1, 2, 3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities. Eur. J. Med. Chem. 49 (2012), 324–333.
21. Büchi, G., Jeger, O., Über einige Verbindungen mit dem Kohlenstoffgerüst des Bicyclo-[0, 5, 5]-dodecans. Helvetica Chim. Acta 32 (1949), 538–544.
22. Ma, K., Li, P.X., Dong, C.C., Thomas, R.K., Penfold, J., Unusual adsorption at the air–water interface of a zwitterionic carboxybetaine with a large charge separation. Langmuir 32 (2016), 3340–3347.
23. De Kievit, T.R., Iglewski, B.H., Bacterial quorum sensing in pathogenic relationships. Infect. Immun. 68 (2000), 4839–4849.
24. Galloway, W.R., Hodgkinson, J.T., Bowden, S.D., Welch, M., Spring, D.R., Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Trends Microb., 2010, 449–458.
25. Welch, M., Mikkelsen, H., Swatton, J.E., Smith, D., Thomas, G.L., Glansdorp, F.G., Spring, D.R., Cell–cell communication in Gram-negative bacteria. Mol. Biosyst. 1 (2005), 196–202.
26. Christensen, L.D., Van Gennip, M., Jakobsen, T.H., Alhede, M., Hougen, H.P., Høiby, N., Bjarnsholt, T., Givskov, M., Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. J. Antimicrob. Chemother. 67 (2012), 1198–1206.
27. Frei, R., Breitbach, A.S., Blackwell, H.E., 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms. Angew. Chem. Int. Ed. 51 (2012), 5226–5229.
28. Kubinyi, H., Hydrogen bonding: the last mystery in drug design. Pharmacokinet. Optim. Drug Res., 2001, 513–524.