Does platelet-rich plasma have a role in the treatment of osteoarthritis?

Joint Bone Spine

Volumn 83, Issue 1, 2016, Pages 31-36

  Ornetti, Paul ^a   Nourissat, Geoffroy ^b,c   Berenbaum, Francis ^c,d   Sellam, Jérémie ^c,d   Richette, Pascal ^e   Chevalier, Xavier ^f  

^a DIJON UNIVERSITY HOSPITAL   (France)

^b Radiology Department   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d HÔPITAL SAINT ANTOINE   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f HENRI MONDOR HOSPITAL   (France)

Author keywords

Hip; Knee; Osteoarthritis; Platelet rich plasma; Review; Treatment

Indexed keywords

CORTICOSTEROID; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANGIOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROCYTE; DRUG EFFECT; DRUG HYPERSENSITIVITY; EXTRACELLULAR MATRIX; HIP OSTEOARTHRITIS; HUMAN; INFECTION; INJECTION PAIN; KNEE OSTEOARTHRITIS; SHORT SURVEY; SYNOVIAL FLUID; SYNOVIOCYTE; THROMBOCYTE RICH PLASMA; TREATMENT OUTCOME; VISCOSUPPLEMENTATION; INTRAARTICULAR DRUG ADMINISTRATION; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PHYSIOLOGY;

INJECTIONS, INTRA-ARTICULAR; OSTEOARTHRITIS; PLATELET-RICH PLASMA;

EID: 85027957489     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2015.05.002     Document Type: Short Survey

References (56)

1. Guillemin, F., Rat, A.-C., Roux, C.H., et al. The KHOALA cohort of knee and hip osteoarthritis in France. Joint Bone Spine 79 (2012), 597–603.
2. Zhang, W., Nuki, G., Moskowitz, R.W., et al. OARSI recommendations for the management of hip and knee osteoarthritis. Osteoarthritis Cartilage 18 (2010), 476–499.
3. Smets, F., Croisier, J.-L., Forthomme, B., Applications cliniques du plasma riche en plaquettes (PRP) dans les lésions tendineuses: revue de la littérature. Sci Sports 27 (2012), 141–153.
4. Xie, X., Zhang, C., Tuan, R.S., Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther, 16, 2014, 204.
5. Sheth, U., Simunovic, N., Klein, G., et al. Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg 94 (2012), 298–307.
6. Andia, I., Sánchez, M., Maffulli, N., Joint pathology and platelet-rich plasma therapies. Expert Opin Biol Ther 12 (2012), 7–22.
7. Anitua, E., Sanchez, M., Nurden, A.T., et al. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol 24 (2006), 227–234.
8. Andia, I., Maffulli, N., Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol 9 (2013), 721–730.
9. Zhu, Y., Yuan, M., Meng, H.Y., et al. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthritis Cartilage 21 (2013), 1627–1637.
10. Malgoyre, A., Bigard, X., Alonso, A., et al. Variabilité des compositions cellulaire et moléculaire des extraits de concentrés plaquettaires (platelet-rich plasma, PRP). J Traumatol Sport 29 (2012), 236–240.
11. Sundman, E.A., Cole, B.J., Fortier, L.A., Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med 39 (2011), 2135–2140.
12. Fortier, L.A., Hackett, C.H., Cole, B.J., The effects of platelet-rich plasma on cartilage: basic science and clinical application. Oper Tech Sports Med 19 (2011), 154–159.
13. Sellam, J., Berenbaum, F., The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 6 (2010), 625–635.
14. Sun, Y., Feng, Y., Zhang, C.Q., et al. The regenerative effect of platelet-rich plasma on healing in large osteochondral defects. Int Orthop 34 (2010), 589–597.
15. Dohan Ehrenfest, D.M., Rasmusson, L., Albrektsson, T., Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27 (2009), 158–167.
16. Watson, S.P., Bahou, W.F., Fitzgerald, D., et al. Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee. J Thromb Haemost 3 (2005), 2098–2101.
17. Kang, Y.-H., Jeon, S.H., Park, J.-Y., et al. Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration. Tissue Eng 17 (2011), 349–359.
18. Cieslik-Bielecka, A., Gazdzik, T.S., Bielecki, T.M., et al. Why the platelet-rich gel has antimicrobial activity?. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 (2007), 303–305.
19. DeLong, J.M., Russell, R.P., Mazzocca, A.D., Platelet-rich plasma: the PAW classification system. Arthrosc J Arthrosc Relat Surg 28 (2012), 998–1009.
20. Filardo, G., Kon, E., Roffi, A., et al. Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc, 2013 [Internet], [cited 2014 Mar 15]; Available from: http://link.springer.com/10.1007/s00167-013-2743-1.
21. Bielecki, T.M., Gazdzik, T.S., Arendt, J., et al. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br 89 (2007), 417–420.
22. Bernuzzi, G., Petraglia, F., Pedrini, M.F., et al. Use of platelet-rich plasma in the care of sports injuries: our experience with ultrasound-guided injection. Blood Transfus 12 (2014), s229–s234.
23. Spreafico, A., Chellini, F., Frediani, B., et al. Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. J Cell Biochem 108 (2009), 1153–1165.
24. Chien, C.S., Ho, H.O., Liang, Y.C., et al. Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage. J Biomed Mater Res B Appl Biomater 100 (2012), 948–955.
25. Kaps, C., Loch, A., Haisch, A., et al. Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes. Med Biol Eng Comput 40 (2002), 485–490.
26. Drengk, A., Zapf, A., Sturmer, E.K., et al. Frosch K-H. Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells. Cells Tissues Organs 189 (2009), 317–326.
27. Park, S.I., Lee, H.R., Kim, S., et al. Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures. Mol Cell Biochem 361 (2012), 9–17.
28. Gaissmaier, C., Fritz, J., Krackhardt, T., et al. Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures. Biomaterials 26 (2005), 1953–1960.
29. Qi, Y.Y., Chen, X., Jiang, Y.Z., et al. Local delivery of autologous platelet in collagen matrix simulated in situ articular cartilage repair. Cell Transpl 18 (2009), 1161–1169.
30. Mishra, A., Tummala, P., King, A., et al. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng 15 (2009), 431–435.
31. Mifune, Y., Matsumoto, T., Takayama, K., et al. The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthritis Cartilage 21 (2013), 175–185.
32. Akeda, K., An, H.S., Okuma, M., et al. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage 14 (2006), 1272–1280.
33. Saito, M., Takahashi, K.A., Arai, Y., et al. Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. Clin Exp Rheumatol 27 (2009), 201–207.
34. Kwon, D.R., Park, G.Y., Lee, S., The effects of intra-articular platelet-rich plasma injection according to the severity of collagenase-induced knee osteoarthritis in a rabbit model. Ann Rehabil Med, 36, 2012, 458.
35. Braun, H.J., Kim, H.J., Chu, C.R., et al. The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy. Am J Sports Med 42 (2014), 1204–1210.
36. Anitua, E., Sanchez, M., Nurden, A.T., et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatol Oxf 46 (2007), 1769–1772.
37. Bendinelli, P., Matteucci, E., Dogliotti, G., et al. Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-κB inhibition via HGF. J Cell Physiol 225 (2010), 757–766.
38. Anitua, E., Sánchez, M., Zalduendo, M.M., et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif 42 (2009), 162–170.
39. Browning, S.R., Weiser, A.M., Woolf, N., et al. Platelet-rich plasma increases matrix metalloproteinases in cultures of human synovial fibroblasts. J Bone Joint Surg Am 5 (2012), 1721–1727.
40. Montaseri, A., Busch, F., Mobasheri, A., et al. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One, 6, 2011 [Internet].
41. Van Buul, G.M., Koevoet, W.L.M., Kops, N., et al. Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. Am J Sports Med 39 (2011), 2362–2370.
42. Lippross, S., Moeller, B., Haas, H., et al. Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint. Arthritis Rheum 63 (2011), 3344–3353.
43. Battaglia, M., Guaraldi, F., Vannini, F., et al. Platelet-rich plasma (PRP) intra-articular ultrasound-guided injections as a possible treatment for hip osteoarthritis: a pilot study. Clin Exp Rheumatol, 29, 2011, 754.
44. Sanchez, M., Guadilla, J., Fiz, N., et al. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology 51 (2012), 144–150.
45. Battaglia, M., Guaraldi, F., Vannini, F., et al. Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics 36 (2013), e1501–e1508.
46. Halpern, B., Chaudhury, S., Rodeo, S.A., et al. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med 23 (2013), 238–239.
47. Patel, S., Dhillon, M.S., Aggarwal, S., et al. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med 41 (2013), 356–364.
48. Chang, K.-V., Hung, C.-Y., Aliwarga, F., et al. Comparative Effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. Arch Phys Med Rehabil 95 (2014), 562–575.
49. Cerza, F., Carni, S., Carcangiu, A., et al. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med 40 (2012), 2822–2827.
50. Filardo, G., Kon, E., Di Martino, A., et al. Platelet-rich plasma vs. hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord, 13, 2012, 229.
51. Kon, E., Mandelbaum, B., Buda, R., et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthrosc J Arthrosc Relat Surg 27 (2011), 1490–1501.
52. Sánchez, M., Fiz, N., Azofra, J., et al. A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis. Arthrosc J Arthrosc Relat Surg 28 (2012), 1070–1078.
53. Spaková, T., Rosocha, J., Lacko, M., et al. Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid. Am J Phys Med Rehabil 91 (2012), 411–417.
54. Mei-Dan, O., Carmont, M.R., Laver, L., et al. Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus. Am J Sports Med 40 (2012), 534–541.
55. Zhang, W., Robertson, J., Jones, A.C., et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis 67 (2008), 1716–1723.
56. Andia, I., Abate, M., Knee osteoarthritis: hyaluronic acid, platelet-rich plasma or both in association?. Expert Opin Biol Ther, 2014, 1–15.