Management of the patient with incomplete response to PPI therapy

Best Practice and Research: Clinical Gastroenterology

Volumn 27, Issue 3, 2013, Pages 401-414

  Kahrilas, Peter J ^a   Boeckxstaens, Guy ^b   Smout, Andre J P M ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Ambulatory oesophageal; Ambulatory oesophageal pH impedance monitoring; Gastroesophageal reflux disease; Oesophagus; pH monitoring; Proton pump inhibitors; Visceral hypersensitivity

Indexed keywords

ALGINIC ACID; CISAPRIDE; CITALOPRAM; ESOMEPRAZOLE; LANSOPRAZOLE; LINAPRAZAN; MOSAPRIDE; OMEPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR; RANITIDINE; TRAZODONE;

ACUPUNCTURE; ADD ON THERAPY; ALTERNATIVE MEDICINE; ASTHMA; BARRETT ESOPHAGUS; COUGHING; DISTRESS SYNDROME; EOSINOPHILIC ESOPHAGITIS; ESOPHAGEAL PH MONITORING; ESOPHAGITIS; ESOPHAGUS ACHALASIA; ESOPHAGUS BIOPSY; GASTRIC DYSMOTILITY; GASTROESOPHAGEAL REFLUX; GASTROSCOPY; HEARTBURN; HIATUS HERNIA; HOARSENESS; HUMAN; LARYNGITIS; MAINTENANCE THERAPY; MANOMETRY; NONHUMAN; PHENOTYPE; QUALITY OF LIFE; REVIEW; SINGLE DRUG DOSE; SORE THROAT; STOMACH ACID SECRETION; STOMACH CONTENT; STOMACH FUNDOPLICATION; STOMACH PH; THORAX PAIN; TREATMENT DURATION; TREATMENT RESPONSE;

AMBULATORY OESOPHAGEAL PH MONITORING; AMBULATORY OESOPHAGEAL PH-IMPEDANCE MONITORING; GASTROESOPHAGEAL REFLUX DISEASE; OESOPHAGUS; PROTON PUMP INHIBITORS; VISCERAL HYPERSENSITIVITY;

ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; PROTON PUMP INHIBITORS;

EID: 85027956414     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2013.06.005     Document Type: Review

References (78)

1. P.J. Kahrilas, N.J. Shaheen, M. Vaezi in collaboration with the AGAI Medical Position Panel on GERD Management AGAI medical position statement: management of gastroesophageal reflux disease Gastroenterology 135 2008 1383 1391
2. M.E. Numans, J. Lau, N.J. de Wit, and P.A. Bonis Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics Ann Intern Med 140 2004 518 527
3. P.J. Kahrilas Treatment vs management of gastroesophageal reflux disease (Editorial) Am J Gastroenterol 92 1997 1959 1960
4. N. Vakil, S.V. van Zanten, P. Kahrilas, J. Dent, R. Jones Global Consensus Group The Montreal definition and classification of gastro-esophageal reflux disease (GERD) - a global evidence-based consensus Am J Gastroenterol 101 2006 1900 1920
5. R.S. Sandler, J.E. Everhart, M. Donowitz, E. Adams, K. Cronin, and C. Goodman The burden of selected digestive diseases in the United States Gastroenterology 122 2002 1500 1511
6. J.M. Inadomi, L. McIntyre, L. Bernard, and A.M. Fendrick Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs Am J Gastroenterol 98 2003 1940 1944
7. B.B. Dean, A.D. Gano Jr., K. Knight, J.J. Ofman, and R. Fass Effectiveness of proton pump inhibitors in nonerosive reflux disease Clin Gastroenterol Hepatol 2 2004 656 664
8. P.J. Kahrilas, and G. Boeckxstaens Failure of reflux inhibitors in clinical trials: bad drugs or wrong patients? Gut 61 2012 1501 1509
9. M.P. Jones, S.S. Sloan, J.C. Rabine, C.F. Huang, and P.J. Kahrilas Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease Am J Gastroenterol 96 2001 1711 1717
10. S. Lin, M. Ke, J. Xu, and P.J. Kahrilas Impaired esophageal emptying in reflux disease Am J Gastroenterol 89 1994 1003 1006
11. P. Gillen, P. Keeling, P.J. Byrne, and T.P. Hennessy Barrett's oesophagus: pH profile Br J Surg 74 1987 774 776
12. P. Singh, A. Adamopoulos, R.H. Taylor, and D.G. Colin-Jones Oesophageal motor function before and after healing of oesophagitis Gut 33 1992 1590 1596
13. R.K. Mittal, R.C. Lange, and R.W. McCallum Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia Gastroenterology 92 1987 130 135
14. S. Sloan, and P.J. Kahrilas Impairment of esophageal emptying with hiatal hernia Gastroenterology 100 1991 596 605
15. J.A. Smith, S. Decalmer, A. Kelsall, K. McGuinness, H. Jones, and S. Galloway Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms Gastroenterology 139 3 2010 754 762
16. R.E. Clouse, and P.J. Lustman Use of psychopharmacological agents for functional gastrointestinal disorders Gut 54 2005 1332 1341
17. M.F. Vaezi, J.E. Richter, C.R. Stasney, J.R. Spiegel, R.A. Iannuzzi, and J.A. Crawley Treatment of chronic posterior laryngitis with esomeprazole Laryngoscope 116 2 2006 254 260
18. P.J. Kahrilas, C.W. Howden, and N. Hughes Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux disease Am J Gastroenterol 106 2011 1419 1425
19. P.J. Kahrilas, A. Jonsson, H. Denison, B. Wernersson, N. Hughes, and C.W. Howden Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease Clin Gastroenterol Hepatol 10 2012 612 619
20. P.J. Kahrilas, N. Hughes, and C.W. Howden Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease Gut 60 2011 1473 1478
21. A.B. Chang, T.J. Lasserson, J. Gaffney, F.L. Connor, and L.A. Garske Cochrane Database Syst Rev 1 2011 Jan 19 CD004823
22. P.J. Kahrilas, C.W. Howden, N. Hughes, and M. Molloy-Bland Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease Chest 143 3 2013 605 612
23. R. Dickman, M. Boaz, S. Aizic, Z. Beniashvili, R. Fass, and Y. Niv Comparison of clinical characteristics of patients with gastroesophageal reflux disease who failed proton pump inhibitor therapy versus those who fully responded J Neurogastroenterol Motil 17 4 2011 Oct 387 394
24. P. Bytzer, S.V. van Zanten, H. Mattsson, and B. Wernersson Partial symptom-response to proton pump inhibitors in patients with non-erosive reflux disease or reflux oesophagitis - a post hoc analysis of 5796 patients Aliment Pharmacol Ther 36 7 2012 635 643
25. M.C. Aanen, M.E. Numans, B.L. Weusten, and A.J. Smout Diagnostic value of the Reflux Disease Questionnaire in general practice Digestion 74 2006 162 168
26. M. Miyamoto, N. Manabe, and K. Haruma Efficacy of the addition of prokinetics for proton pump inhibitor (PPI) resistant non-erosive reflux disease (NERD) patients: significance of frequency scale for the symptom of GERD (FSSG) on decision of treatment strategy Intern Med 49 2010 1469 1476
27. P.J. Kahrilas, A. Jonsson, H. Denison, B. Wernersson, N. Hughes, and C.W. Howden Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression Am J Gastroenterol 107 9 2012 1354 1360
28. D.R. Lichtenstein, B.D. Cash, R. Davila, T.H. Baron, D.G. Adler, and M.A. Anderson Role of endoscopy in the management of GERD Gastrointest Endosc 66 2 2007 219 224
29. C.H. Poh, A. Gasiorowska, T. Navarro-Rodriguez, M.R. Willis, D. Hargadon, and N. Noelck Upper GI tract findings in patients with heartburn in whom proton pump inhibitor treatment failed versus those not receiving antireflux treatment Gastrointest Endosc 71 1 2010 28 34
30. N.J. Shaheen, H. Denison, K. Björck, and D.G. Silberg Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy Am J Gastroenterol 108 4 2013 529 534
31. F. Ismail-Beigi, P.F. Horton, and C.E. Pope Histological consequences of gastroesophageal reflux in man Gastroenterology 58 2 1970 163 174
32. N.A. Tobey, J.L. Carson, R.A. Alkiek, and R.C. Orlando Dilated intercellular spaces: a morphological feature of acid reflux - damaged human esophageal epithelium Gastroenterology 111 5 1996 1200 1205
33. M.F. Vela, B.M. Craft, N. Sharma, J. Freeman, and D. Hazen-Martin Refractory heartburn: comparison of intercellular space diameter in documented GERD vs. functional heartburn Am J Gastroenterol 106 5 2011 844 850
34. J.E. Pandolfino, M.A. Schreiner, T.J. Lee, Q. Zhang, C. Boniquit, and P.J. Kahrilas Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure Am J Gastroenterol 100 7 2005 1466 1476
35. B.S. Hakanson, P. Berggren, S. Granqvist, O. Ljungqvist, and A. Thorell Comparison of wireless 48-h (Bravo) versus traditional ambulatory 24-h esophageal pH monitoring Scand J Gastroenterol 44 3 2009 276 283
36. G.J. Wiener, J.E. Richter, J.B. Copper, W.C. Wu, and D.O. Castell The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring Am J Gastroenterol 83 4 1988 358 361
37. B.L. Weusten, J.M. Roelofs, L.M. Akkermans, G.P. Berge-Henegouwen, and A.J. Smout The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data Gastroenterology 107 6 1994 1741 1745
38. J.P. Galmiche, R.E. Clouse, A. Bálint, I.J. Cook, P.J. Kahrilas, and W.G. Paterson Functional esophageal disorders Gastroenterology 130 5 2006 1459 1465
39. D. Sifrim, R. Holloway, J. Silny, Z. Xin, J. Tack, and A. Lerut Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings Gastroenterology 120 7 2001 1588 1598
40. A.J. Bredenoord, B.L. Weusten, W.L. Curvers, R. Timmer, and A.J. Smout Determinants of perception of heartburn and regurgitation Gut 55 3 2005 313 318
41. G.J. Hemmink, A.J. Bredenoord, B.L. Weusten, J.F. Monkelbaan, R. Timmer, and A.J. Smout Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor? Am J Gastroenterol 103 10 2008 2446 2453
42. B.F. Kessing, A.J. Bredenoord, and A.J. Smout Erroneous diagnosis of gastroesophageal reflux disease in achalasia Clin Gastroenterol Hepatol 9 2011 1020 1024
43. J. Ponce, V. Ortiz, N. Maroto, M. Ponce, M. Bustamante, and V. Garrigues High prevalence of heartburn and low acid sensitivity in patients with idiopathic achalasia Dig Dis Sci 56 3 2011 773 776
44. A.J. Bredenoord, R. Tutuian, A.J. Smout, and D.O. Castell Technology review: esophageal impedance monitoring Am J Gastroenterol 102 1 2007 187 194
45. J.G. Hatlebakk, P.O. Katz, L. Camacho-Lobato, and D.O. Castell Proton pump inhibitors: better acid suppression when taken before a meal than without a meal Aliment Pharmacol Ther 14 2000 1267 1272
46. N.T. Gunaratnam, T.P. Jessup, J. Inadomi, and D.P. Lascewski Sub-optimal proton pump inhibitor dosing is prevalent in patients with poorly controlled gastro-oesophageal reflux disease Aliment Pharmacol Ther 23 2006 1473 1477
47. R.C. Orlando, S. Liu, and M. Illueca Relationship between esomeprazole dose and timing to heartburn resolution in selected patients with gastroesophageal reflux disease Clin Exp Gastroenterol 3 2010 117 125
48. R. Fass, S.J. Sontag, B. Traxler, and M. Sostek Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial Clin Gastroenterol Hepatol 4 2006 50 56
49. J. Dent, P.J. Kahrilas, J. Hatlebakk, N. Vakil, H. Denison, and S. Franzén A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease Am J Gastroenterol 103 2008 20 26
50. P.J. Kahrilas, J. Dent, K. Lauritsen, P. Malfertheiner, H. Denison, and S. Franzén A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis Clin Gastroenterol Hepatol 5 2007 1385 1391
51. L.P. Leite, B.T. Johnston, R.J. Just, and D.O. Castell Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy Am J Gastroenterol 91 1996 1527 1531
52. I. Mainie, R. Tutuian, and D.O. Castell Addition of a H2 receptor antagonist to PPI improves acid control and decreases nocturnal acid breakthrough J Clin Gastroenterol 42 2008 676 679
53. 2RA therapy on nocturnal gastric acid breakthrough Gastroenterology 122 2002 625 632
54. S. Vigneri, R. Termini, G. Leandro, S. Badalamenti, M. Pantalena, and V. Savarino A comparison of five maintenance therapies for reflux esophagitis N Engl J Med 333 1995 1106 1110
55. H. Miwa, K. Inoue, K. Ashida, T. Kogawa, A. Nagahara, and S. Yoshida Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease - a double-blind, placebo-controlled study Aliment Pharmacol Ther 33 2011 323 332
56. J. Fletcher, A. Wirz, J. Young, R. Vallance, and K.E. McColl Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal Gastroenterology 121 2001 775 783
57. H. Beaumont, R.J. Bennink, J. de Jong, and G.E. Boeckxstaens The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD Gut 59 2010 441 451
58. W.O. Rohof, R.J. Bennink, A.A. de Ruigh, D.P. Hirsch, A.H. Zwinderman, and G.E. Boeckxstaens Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period Gut 61 2012 1670 1677
59. P.J. Kahrilas, K. McColl, M. Fox, L. O'Rourke, D. Sifrim, and A.J. Smout The acid pocket: a target for treatment in reflux disease? Am J Gastroenterol 2013 Apr 30 10.1038/ajg.2013.132 [Epub ahead of print]
60. E. Savarino, N. de Bortoli, P. Zentilin, I. Martinucci, L. Bruzzone, and M. Furnari Alginate controls heartburn in patients with erosive and nonerosive reflux disease World J Gastroenterol 18 2012 4371 4378
61. W.O. Rohof, R.J. Bennink, A.J. Smout, E. Thomas, and G.E. Boeckxstaens An alginate-antacid formulation localizes to the acid pocket to reduce acid reflux in patients with gastroesophageal reflux disease Clin Gastroenterol Hepatol 2013 May 10 10.1016/j.cgh.2013.04.046 pii: S1542-3565(13)00621-6. [Epub ahead of print]
62. N. Manabe, K. Haruma, M. Ito, N. Takahashi, H. Takasugi, and Y. Wada Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial Dis Esophagus 25 2012 373 380
63. W.D. Chey, R.R. Mody, E.Q. Wu, L. Chen, S. Kothari, and B. Persson Treatment patterns and symptom control in patients with GERD: US community-based survey Curr Med Res Opin 25 2009 1869 1878
64. M.F. Vela, R. Tutuian, P.O. Katz, and D.O. Castell Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH Aliment Pharmacol Ther 17 2003 243 251
65. G.E. Boeckxstaens, and A. Smout Systematic review: role of acid, weakly acidic and weakly alkaline reflux in gastro-oesophageal reflux disease Aliment Pharmacol Ther 32 2010 334 343
66. G.E. Boeckxstaens, H. Beaumont, J.G. Hatlebakk, D.G. Silberg, K. Björck, and M. Karlsson A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial Gut 60 2011 1182 1188
67. N.J. Shaheen, H. Denison, K. Bjorck, M. Karlsson, and D.G. Silberg Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial Gut 2012 Jun 23 [Epub ahead of print]
68. G.H. Koek, D. Sifrim, T. Lerut, J. Janssens, and J. Tack Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro- oesophageal reflux refractory to proton pump inhibitors Gut 52 2003 1397 1402
69. C. Prakash, and R.E. Clouse Long-term outcome from tricyclic antidepressant treatment of functional chest pain Dig Dis Sci 44 12 1999 Dec 2373 2379
70. R.E. Clouse, P.J. Lustman, T.C. Eckert, D.M. Ferney, and L.S. Griffith Low-dose trazodone for symptomatic patients with esophageal contraction abnormalities. A double-blind, placebo-controlled trial Gastroenterology 92 4 1987 1027 1036
71. D. Broekaert, B. Fischler, D. Sifrim, J. Janssens, and J. Tack Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: a double-blind, placebo-controlled study Aliment Pharmacol Ther 23 3 2006 365 370
72. R. Dickman, E. Schiff, A. Holland, C. Wright, S.R. Sarela, and B. Han Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn Aliment Pharmacol Ther 26 10 2007 1333 1344
73. B. Nojkov, J.H. Rubenstein, S.A. Adlis, M.J. Shaw, R. Saad, and J. Rai The influence of co-morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro-oesophageal reflux disease Aliment Pharmacol Ther 27 6 2008 473 482
74. J.L. Kiebles, M.A. Kwiatek, J.E. Pandolfino, P.J. Kahrilas, and L. Keefer Do patients with globus sensation respond to hypnotically assisted relaxation therapy? A case series report Dis Esophagus 23 7 2010 545 553
75. L. Lundell, S. Attwood, C. Ell, R. Fiocca, J.P. Galmiche, and J. Hatlebakk Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial Gut 57 9 2008 1207 1213
76. J.P. Galmiche, J. Hatlebakk, S. Attwood, C. Ell, R. Fiocca, and S. Eklund Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD. The LOTUS randomized clinical trial J Am Med Assoc 305 2011 1969 1977
77. N. Vakil, M. Shaw, and R. Kirby Clinical effectiveness of laparoscopic fundoplication in a U.S. community Am J Med 114 1 2003 1 5
78. J.G. Hunter, C.D. Smith, G.D. Branum, J.P. Waring, T.L. Trus, and M. Cornwell Laparoscopic fundoplication failures: patterns of failure and response to fundoplication revision Ann Surg 230 4 1999 595 604