Use of immune function test in monitoring immunosuppression in liver transplant recipients

Clinical Transplantation

Volumn 26, Issue 6, 2012, Pages 826-832

  Te, Helen S ^a   Dasgupta, Kathleen A ^a   Cao, Dingcai ^b   Satoskar, Rohit ^c   Mohanty, Smruti R ^a   Reau, Nancy ^a   Millis, James Michael ^a   Jensen, Donald M ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Immune function test; Immunosuppression; Liver transplantation

Indexed keywords

CYCLOSPORIN A; MYCOPHENOLIC ACID; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; DRUG DOSE REDUCTION; FEMALE; FOLLOW UP; GRAFT RECIPIENT; HUMAN; IMMUNE FUNCTION TEST; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PATIENT MONITORING; PRIORITY JOURNAL; TREATMENT RESPONSE;

EID: 85027953824     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2012.01632.x     Document Type: Article

References (21)

1. Kowalski RJ, Post DR, Mannon RB, et al. Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation 2006: 82: 663.
2. Cyclex Incorporated. Immuknow, Cyclex Immune Cell Function Assay. Columbia, MD: Package Insert, 2007.
3. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986: 73: 13.
4. Utecht KN, Hiles JJ, Kolesar J. Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors. Am J Health Syst Pharm 2006: 63: 2340.
5. Meier-Kriesche HU, Ojo A, Hanson J, et al. Increased immunosuppressive vulnerability in elderly renal transplant recipients. Transplantation 2000: 69: 885.
6. Kowalski R, Post D, Schneider MC, et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003: 17: 77.
7. Gautam A, Fischer SA, Yango AF, et al. Cell mediated immunity (CMI) and post transplant viral infections-role of a functional immune assay to titrate immunosuppression. Int Immunopharmacol 2006: 6: 2023.
8. Gautam A, Fischer SA, Yango AF, et al. Suppression of cell-mediated immunity by a donor-transmitted lymphocytic choriomeningitis virus in a kidney transplant recipient. Transplant Infect Dis 2007: 9: 339.
9. Lee TC, Goss JA, Rooney CM, et al. Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clin Transplant 2006: 20: 689.
10. Batal I, Zeevi A, Heider A, et al. Measurements of global cell-mediated immunity in renal transplant recipients with BK virus reactivation. Am J Clin Pathol 2008: 129: 587.
11. Thai NL, Blisard D, Tom K, et al. Pancreas transplantation under alemtuzumab (Campath-1H) and tacrolimus: Correlation between low T-cell responses and infection. Transplantation 2006: 82: 1649.
12. Hirose K, Aucejo F, Hashimoto K, et al. Very low values of Cyclex immune cell function assay is associated with early post-operative death following liver transplantation (abstract). Am J Transplant 2007: 7: 550.
13. Israeli M, Klein T, Sredni B, et al. ImmuKnow: a new parameter in immune monitoring of pediatric liver transplantation recipients. Liver Transpl 2008: 14: 893.
14. Sampson VB, Dunn SP, Rymeski B, et al. Failure of immunosuppressive drug levels to predict T-cell reactivity in pediatric transplant patients. J Pediatr Surg 2008: 43: 1134.
15. Bhorade SM, Janata K, Vigneswaran WT, et al. Cylex ImmuKnow assay levels are lower in lung transplant recipients with infection. J Heart Lung Transplant 2008: 27: 990.
16. ® immune monitoring in post liver transplant hepatitis C results in improved patient outcomes due to optimal immune suppression dosing (abstract). Am J Tranplant 2007: 7: 240.
17. Mendler M, Kwok H, Franco E, et al. Monitoring peripheral blood CD4 + adenosine triphosphate activity in a liver transplant cohort: insight into the interplay between hepatitis C virus infection and cellular immunity. Liver Transpl 2008: 14: 1313.
18. Alkhouri N, Hanouneh IA, Lopez R, et al. Monitoring peripheral blood CD4 + adenosine triphosphate activity in recurrent hepatitis C and its correlation to fibrosis progression. Liver Transpl 2010: 16: 155.
19. Cabrera R, Ararat M, Soldevila-Pico C, et al. Using an immune functional assay to differentiate acute cellular rejection from recurrent hepatitis C in liver transplant patients. Liver Transpl 2009: 15: 216.
20. Hashimoto K, Miller C, Hirose K, et al. Measurement of CD4+ T-cell function in predicting allograft rejection and recurrent hepatitis C after liver transplantation. Clin Transplant 2010: 24: 701.
21. Huang J, Lopez-Cepero M, Mayes J, et al. Decreased cellular immune response in hepatitis C patients awaiting liver transplantation (abstract). Am J Tranplant 2004: 4: 362.