Suppression of cell-mediated immunity by a donor-transmitted lymphocytic choriomeningitis virus in a kidney transplant recipient

Transplant Infectious Disease

Volumn 9, Issue 4, 2007, Pages 339-342

  Gautam, Amitabh ^a,b   Fischer, S A ^a,b   Yango, A F ^a,b   Gohh, R Y ^a,b   Morrissey, P E ^a,b   Monaco, A P ^a,b  

^a RHODE ISLAND HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

CD4 positive T lymphocytes; Cellular immunity; Immunologic monitoring; Kidney transplantation; Lymphocytic choriomeningitis virus

Indexed keywords

MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RIBAVIRIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; CASE REPORT; CELLULAR IMMUNITY; CREATININE BLOOD LEVEL; DIARRHEA; DRUG WITHDRAWAL; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; PRIORITY JOURNAL; VIRUS IDENTIFICATION; VIRUS MENINGITIS;

FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOSUPPRESSION; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MIDDLE AGED; TISSUE DONORS;

EID: 35848965908     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2007.00232.x     Document Type: Article

References (7)

1. Fischer SA, Graham MB, Kuehnert MJ, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med 2006 354 : 2235 2249.
2. Kowalski R, Post D, Schneider MC, et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003 17 : 77 88.
3. Bro-Jørgensen K, Güttler F, Jørgensen PN, Volkert M. T lymphocyte function as the principal target of lymphocytic choriomeningitis virus-induced immunosuppression. Infect Immun 1975 11 : 622 629.
4. Gallimore A, Glithero A, Godkin A, et al. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med 1998 187 : 1383 1393.
5. Sevilla N, McGavern DB, Teng C, Kunz S, Oldstone MBA. Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion. J Clin Invest 2004 113 : 737 745.
6. Brooks DG, Teyton L, Oldstone MBA, McGavern DB. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J Virol 2005 79 : 10514 10527.
7. Müller TF, Grebe SO, Neumann MC, et al. Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies. Transplantation 1997 64 : 1432 1437.