Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection

Pancreatology

Volumn 13, Issue 1, 2013, Pages 38-42

  Benini, Luigi ^a   Amodio, Antonio ^a   Campagnola, Pietro ^a   Agugiaro, Flora ^a   Cristofori, Chiara ^a   Micciolo, Rocco ^b   Magro, Alessandra ^a   Gabbrielli, Armando ^a   Cabrini, Giulio ^c   Moser, Luisa ^a   Massella, Arianna ^a   Vantini, Italo ^a   Frulloni, Luca ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF TRENTO   (Italy)

^c Azienda Integrata University Hospital   (Italy)

Author keywords

Malabsorption syndromes; Pancreatic insufficiency; Surgery

Indexed keywords

ELASTASE; FECAL ELASTASE 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALABSORPTION; MALE; PANCREAS DISEASE; PANCREAS RESECTION; PRIORITY JOURNAL; SCHOOL CHILD; STEATORRHEA;

EID: 85027948830     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2012.11.307     Document Type: Article

References (24)

1. Frulloni L, Falconi M, Gabbrielli A, Gaia E, Graziani R, Pezzilli R, et al. Italian consensus guidelines for chronic pancreatitis. Dig Liver Dis 2010;42(Suppl. 6): S381-S406.
2. Benini L, Caliari S, Guidi GC, Vaona V, Talamini G, Vantini I, et al. Near infrared spectrometry for fecal fat measurement: comparison with conventional gravimetric and tritimetric methods. Gut 1989;30:1344-7. (Pubitemid 19270141)
3. Korpi-Steiner NL, Ward JN, Kumar V, McConnell JP. Comparative analysis of fecal fat quantitation via nuclear magnetic resonance spectroscopy (1H NMR) and gravimetry. Clinica Chim Acta 2009;400:33-6.
4. Di Magno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 1973;288:813-5.
5. Loser C, Mollgaard A, Folsch UR. Fecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test. Gut 1996;39:580-6. (Pubitemid 26376043)
6. Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med 2002;40(4):325-32. (Pubitemid 34546225)
7. Stein J, Jung M, Sziegoleit A, Zeuzem S, Caspary WF, Lembcke B. Immunoreactive elastase-1: clinical evaluation of a new noninvasive test of pancreatic function. Clin Chem 1996;42:222-6. (Pubitemid 26063874)
8. Sziegoleit A, Krause E, Klor HU, Kanacher L, Linder D. Elastase and chymotrypsyn B in pancreatic juice and feces. Clin Biochem 1989;22:85.
9. Elphick DA, Kapur K. Comparing the urinary pancreolauryl ratio and faecl elastase-1as indicators of pancreatic insufficiency in clinical practice. Pancreatology 2005;5:196-200. (Pubitemid 40754736)
10. Sonwalkar SA, Holbrook IB, Phillips I, Lelly SM. A prospective, comparative study of the para-aminobenzoic acid test and fecal elastase 1 in the assessment of exocrine pancreatic function. Aliment Pharmacol Ther 2003; 17:467-71. (Pubitemid 36259411)
11. Bilgin M, Balci NC, Momtahen AJ, Bilgin Y, Klör HU, Rau WS. MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. J Clin Gastroenterol 2009;43:165-70.
12. Gillams A, Pereira S, Webster G, Lees W. Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests. Abdom Imaging 2008;33:469-73. (Pubitemid 351713081)
13. Uskudar O, Oguz D, Akdogan M, Altiparmak E, Sahin B. Comparison of endoscopic retrograde cholangio-pancreatography, endoscopic ultrasonography, and fecal elastase 1 in chronic pancreatitis and clinical correlation. Pancreas 2009;38:503-6.
14. Symersky T, van der Zon A, Biemond I, Masclee AA. Fecal elastase-1: helpful in analysing steatorrhoea? Neth J Med 2004;62(8):286-9.
15. Thomas PD, Forbes A, Green J, Howdle P, Long R, Playford R, et al. Guidelines for the investigation of chronic diarrhoea, 2nd edition. Gut 2003;52(Suppl. 5):1-15.
16. Lankisch PG, Schmidt I, Konig H, Lehnick D, Knollmann R, Löhr M, et al. Fecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. Gut 1998;42:551-4. (Pubitemid 28186574)
17. Amann ST, Bishop M, Curington C, Toskes PP. Elastase 1 is inaccurate in the diagnosis of chronic pancreatitis. Pancreas 1996;13:226-30. (Pubitemid 26317989)
18. Van de Kamer J, Ten Bookkel HH, Weyers H. Rapid method for the determination of fat in feces. J Biol Chem 1949:347-55.
19. Erikson JA, Aldeen WE, Grenache DG, Ashwood ER. Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: assessment versus an established assay and implication in classifying pancreatic function. Clin Chim Acta 2008;397:87-91.
20. Icks A, Haastert B, Giani G, Rathmann W. Low fecal elastase-1 in type I diabetes mellitus. Z Gastroenterol 2001;39:823-30. (Pubitemid 33020961)
21. Hardt PD, Hauenschild A, Nalop J, Marzeion AM, Jaeger C, Teichmann J, et al. High prevalence of exocrine pancreatic insufficiency in diabetes mellitus: a multicenter study screening fecal elastase 1 concentrations in 1, 021 diabetic patients. Pancreatology 2003;3:395-402. (Pubitemid 37409868)
22. Hahn JU, Kerner W, Maisonneuve P, Lowenfels AB, Lankisch PG. Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus. Pancreas 2008;36:274-8. (Pubitemid 351440932)
23. Halloran MC, Cox TF, Chauhan S, Raraty MGT, Sutton R, Neoptolemos JP, et al. Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study. Pancreatology 2011;11:535-45.
24. Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, et al. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin Gastroenterol Hepatol 2010;8:433-8.