A pilot study on an attenuated Chinese EIAV vaccine inducing broadly neutralizing antibodies

Archives of Virology

Volumn 156, Issue 8, 2011, Pages 1455-1462

  Meng, Qinglai ^a   Lin, Yuezhi ^b   Ma, Jian ^b   Ma, Yan ^a   Zhao, Liping ^b   Li, Shenwei ^a   Liang, Hua ^a   Zhou, Jianhua ^b   Shen, Rongxian ^b   Zhang, Xiaoyan ^a,c   Shao, Yiming ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS;

EID: 85027946090     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-011-0992-1     Document Type: Article

References (22)

1. Cohen J (2004) HIV/AIDS in China. Vaccine development with a distinctly Chinese flavor. Science 304: 1437.
2. Craigo JK, Li F, Steckbeck JD, Durkin S, Howe L, Cook SJ, Issel C, Montelaro RC (2005) Discerning an effective balance between equine infectious anemia virus attenuation and vaccine efficacy. J Virol 79: 2666-2677.
3. Craigo JK, Durkin S, Sturgeon TJ, Tagmyer T, Cook SJ, Issel CJ, Montelaro RC (2007) Immune suppression of challenged vaccinates as a rigorous assessment of sterile protection by lentiviral vaccines. Vaccine 25: 834-845.
4. Dhillon AK, Donners H, Pantophlet R, Johnson WE, Decker JM, Shaw GM, Lee FH, Richman DD, Doms RW, Vanham G, Burton DR (2007) Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors. J Virol 81: 6548-6562.
5. Hammond SA, Cook SJ, Lichtenstein DL, Issel CJ, Montelaro RC (1997) Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process. J Virol 71: 3840-3852.
6. Issel CJ, Coggins L (1979) Equine infectious anemia: current knowledge. J Am Vet Med Assoc 174: 727-733.
7. Li F, Craigo JK, Howe L, Steckbeck JD, Cook S, Issel C, Montelaro RC (2003) A live attenuated equine infectious anemia virus proviral vaccine with a modified S2 gene provides protection from detectable infection by intravenous virulent virus challenge of experimentally inoculated horses. J Virol 77: 7244-7253.
8. Liang H, He X, Shen RX, Shen T, Tong X, Ma Y, Xiang WH, Zhang XY, Shao YM (2006) Combined amino acid mutations occurring in the envelope closely correlate with pathogenicity of EIAV. Arch Virol 151: 1387-1403.
9. Lichtenstein DL, Rushlow KE, Cook RF, Raabe ML, Swardson CJ, Kociba GJ, Issel CJ, Montelaro RC (1995) Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity. J Virol 69: 2881-2888.
10. Liu L, Wan Y, Wu L, Sun J, Li H, Ma L, Shao Y (2010) Broader HIV-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the EIAV attenuated vaccine. Retrovirology 7: 71.
11. Ma J, Jiang C, Lin Y, Wang X, Zhao L, Xiang W, Shao Y, Shen R, Kong X, Zhou J (2009) In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine. Arch Virol 154: 867-873.
12. Qi X, Wang X, Wang S, Lin Y, Jiang C, Ma J, Zhao L, Lv X, Shen R, Wang F, Kong X, Su Z, Zhou J (2010) Genomic analysis of an effective lentiviral vaccine-attenuated equine infectious anemia virus vaccine EIAV FDDV13. Virus Genes 41: 86-98.
13. Sather DN, Armann J, Ching LK, Mavrantoni A, Sellhorn G, Caldwell Z, Yu X, Wood B, Self S, Kalams S, Stamatatos L (2009) Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J Virol 83: 757-769.
14. Sellon DC, Fuller FJ, McGuire TC (1994) The immunopathogenesis of equine infectious anemia virus. Virus Res 32: 111-138.
15. Shen R, Xu Z, He Y, Zhang S (1979) Study on vaccination of equine infectious anemia. Chin Agric Sci 12: 1-15.
16. Shen R, Wang Z (1985) Development and use of an equine infectious aneamia donkey leukocyte attenuated vaccine. EIAV: a national review of policies, programs, and future objectives. American Quarter Horse Association, Amarillo, pp 135-148.
17. Shen R, Wang Z, Dong J, Peng D, Jia B, Lv X, Zhao L, Xiang W (2001) Fetal donkey dermal cells adapted attenuated vaccine of equine infectious anemia virus and its culture method. (Chinese patent No. 01123620) China.
18. Shen T, Liang H, Tong X, Fan X, He X, Ma Y, Xiang W, Shen R, Zhang X, Shao Y (2006) Amino acid mutations of the infectious clone from Chinese EIAV attenuated vaccine resulted in reversion of virulence. Vaccine 24: 738-749.
19. Simek MD, Rida W, Priddy FH, Pung P, Carrow E, Laufer DS, Lehrman JK, Boaz M, Tarragona-Fiol T, Miiro G, Birungi J, Pozniak A, McPhee DA, Manigart O, Karita E, Inwoley A, Jaoko W, Dehovitz J, Bekker LG, Pitisuttithum P, Paris R, Walker LM, Poignard P, Wrin T, Fast PE, Burton DR, Koff WC (2009) Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol 83: 7337-7348.
20. Tagmyer TL, Craigo JK, Cook SJ, Even DL, Issel CJ, Montelaro RC (2008) Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition. J Virol 82: 4052-4063.
21. Tumas DB, Hines MT, Perryman LE, Davis WC, McGuire TC (1994) Corticosteroid immunosuppression and monoclonal antibody-mediated CD5+ T lymphocyte depletion in normal and equine infectious anaemia virus-carrier horses. J Gen Virol 75(Pt 5): 959-968.
22. Zhang X, Wang Y, Liang H, Wei L, Xiang W, Shen R, Shao Y (2007) Correlation between the induction of Th1 cytokines by an attenuated equine infectious anemia virus vaccine and protection against disease progression. J Gen Virol 88: 998-1004.