Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage

Matrix Biology

Volumn 40, Issue , 2014, Pages 27-33

  Miyamoto, Alison ^a   Donovan, Lauren J ^a   Perez, Edgar ^a   Connett, Breanna ^a   Cervantes, Richard ^a   Lai, Khang ^a   Withers, Gordon ^a   Hogrebe, Gregory ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Fibrillin; MAGP2; MFAP5; Microfibril; Proprotein convertase

Indexed keywords

AMINO ACID; FIBRILLIN 2; MAGP2 PROTEIN; PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; IMMUNOFLUORESCENCE; MOUSE; MUTATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T3 CELL LINE; TUMOR CELL LINE;

EID: 85027933315     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2014.08.003     Document Type: Article

References (25)

1. Albig A.R., Roy T.G., Becenti D.J., Schiemann W.P. Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis. Angiogenesis 2007, 10:197-216.
2. Albig A.R., Becenti D.J., Roy T.G., Schiemann W.P. Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. Microvasc. Res. 2008, 76:7-14.
3. Baldwin A.K., Cain S.A., Lennon R., Godwin A., Merry C.L., Kielty C.M. Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils. J. Cell Sci. 2014, 127:158-171.
4. Cain S.A., McGovern A., Small E., Ward L.J., Baldock C., Shuttleworth A., Kielty C.M. Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach. Mol. Cell. Proteomics 2009, 8:2715-2732.
5. Combs M.D., Knutsen R.H., Broekelmann T.J., Toennies H.M., Brett T.J., Miller C.A., Kober D.L., Craft C.S., Atkinson J.J., Shipley J.M., Trask B.C., Mecham R.P. Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J. Biol. Chem. 2013, 288:28869-28880.
6. Donovan L.J., Cha S.E., Yale A.R., Dreikorn S., Miyamoto A. Identification of a functional proprotein convertase cleavage site in microfibril-associated glycoprotein 2. Matrix Biol. 2013, 32:117-122.
7. Gibson M.A., Hatzinikolas G., Kumaratilake J.S., Sandberg L.B., Nicholl J.K., Sutherland G.R., Cleary E.G. Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). J. Biol. Chem. 1996, 271:1096-1103.
8. Gibson M.A., Finnis M.L., Kumaratilake J.S., Cleary E.G. Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1. J. Histochem. Cytochem. 1998, 46:871-886.
9. Gibson M.A., Leavesley D.I., Ashman L.K. Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via alphaVbeta3 integrin. J. Biol. Chem. 1999, 274:13060-13065.
10. Hanssen E., Hew F.H., Moore E., Gibson M.A. MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. J. Biol. Chem. 2004, 279:29185-29194.
11. Kinsey R., Williamson M.R., Chaudhry S., Mellody K.T., McGovern A., Takahashi S., Shuttleworth C.A., Kielty C.M. Fibrillin-1 microfibril deposition is dependent on fibronectin assembly. J. Cell Sci. 2008, 121:2696-2704.
12. Lemaire R., Korn J.H., Shipley J.M., Lafyatis R. Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma. Arthritis Rheum. 2005, 52:1812-1823.
13. Lemaire R., Bayle J., Mecham R.P., Lafyatis R. Microfibril-associated MAGP-2 stimulates elastic fiber assembly. J. Biol. Chem. 2007, 282:800-808.
14. Lonnqvist L., Reinhardt D., Sakai L., Peltonen L. Evidence for furin-type activity-mediated C-terminal processing of profibrillin-1 and interference in the processing by certain mutations. Hum. Mol. Genet. 1998, 7:2039-2044.
15. Miyamoto A., Lau R., Hein P.W., Shipley J.M., Weinmaster G. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. J. Biol. Chem. 2006, 281:10089-10097.
16. Mok S.C., Bonome T., Vathipadiekal V., Bell A., Johnson M.E., Wong K.K., Park D.C., Hao K., Yip D.K., Donninger H., Ozbun L., Samimi G., Brady J., Randonovich M., Pise-Masison C.A., Barrett J.C., Wong W.H., Welch W.R., Berkowitz R.S., Birrer M.J. A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2. Cancer Cell 2009, 16:521-532.
17. Nehring L.C., Miyamoto A., Hein P.W., Weinmaster G., Shipley J.M. The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. J. Biol. Chem. 2005, 280:20349-20355.
18. Penner A.S., Rock M.J., Kielty C.M., Shipley J.M. Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. J. Biol. Chem. 2002, 277:35044-35049.
19. Raghunath M., Putnam E.A., Ritty T., Hamstra D., Park E.S., Tschodrich-Rotter M., Peters R., Rehemtulla A., Milewicz D.M. Carboxy-terminal conversion of profibrillin to fibrillin at a basic site by PACE/furin-like activity required for incorporation in the matrix. J. Cell Sci. 1999, 112(Pt 7):1093-1100.
20. Ramirez F., Sakai L.Y. Biogenesis and function of fibrillin assemblies. Cell Tissue Res. 2010, 339:71-82.
21. Sabatier L., Chen D., Fagotto-Kaufmann C., Hubmacher D., McKee M.D., Annis D.S., Mosher D.F., Reinhardt D.P. Fibrillin assembly requires fibronectin. Mol. Biol. Cell 2009, 20:846-858.
22. Segade F., Trask B.C., Broekelmann T.J., Pierce R.A., Mecham R.P. Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. J. Biol. Chem. 2002, 277:11050-11057.
23. Seidah N.G., Sadr M.S., Chrétien M., Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J. Biol. Chem. 2013, 288:21473-21481.
24. Weinbaum J.S., Tranquillo R.T., Mecham R.P. The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix. Macromol. Biosci. 2010, 10:1338-1344.
25. Xing D., Orsulic S. A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:6936-6941.