Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

Chemico-Biological Interactions

Volumn 205, Issue 1, 2013, Pages A1-A5

  Dietrich, Daniel R ^a   Aulock, Sonja von ^a   Marquardt, Hans ^a   Blaauboer, Bas ^a   Dekant, Wolfgang ^a   Kehrer, James ^a   Hengstler, Jan ^a   Collier, Abby ^a   Gori, Gio Batta ^a   Pelkonen, Olavi ^a   Lang, Florian ^a   Barile, Frank A ^a   Nijkamp, Frans P ^a   Stemmer, Kerstin ^a   Li, Albert ^a   Savolainen, Kai ^a   Hayes, A Wallace ^b   Gooderham, Nigel ^c   Harvey, Alan ^a  

^a Chemico Biological Interactions ^*

^b Food and Chemical Toxicology

^c Toxicology Research

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCRINE DISRUPTOR;

ADVISORY COMMITTEE; ANIMAL; ECOTOXICOLOGY; EDITORIAL; EUROPE; EXPERT WITNESS; HUMAN; RISK ASSESSMENT; STANDARD; TOXICOLOGY;

ADVISORY COMMITTEES; ANIMALS; ECOTOXICOLOGY; ENDOCRINE DISRUPTORS; EUROPE; EXPERT TESTIMONY; HUMANS; RISK ASSESSMENT; TOXICOLOGY;

MLCS; MLOWN;

EID: 85027930236     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.07.001     Document Type: Editorial

References (10)

1. Birnbaum, L.S., When environmental chemicals act like uncontrolled medicine. Trends Endocrinol. Metab. 24 (2013), 321–323.
2. Boobis, A.R., Daston, G.P., Preston, R.J., Olin, S.S., Application of key events analysis to chemical carcinogens and noncarcinogens. Crit. Rev. Food Sci. Nutr. 49 (2009), 690–707.
3. Borgert, C.J., Sargent, E.V., Casella, G., Dietrich, D.R., McCarty, L.S., Golden, R.J., The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments. Regul. Toxicol. Pharmacol. 62 (2012), 313–328.
4. Committee, E.F.S.A.S., Scientific opinion on the hazard assessment of endocrine disruptors: scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment. EFSA J. 11 (2013), 3132–3216.
5. Piersma, A.H., Hernandez, L.G., van Benthem, J., Muller, J.J., van Leeuwen, F.X., Vermeire, T.G., van Raaij, M.T., Reproductive toxicants have a threshold of adversity. Crit. Rev. Toxicol. 41 (2011), 545–554.
6. Rhomberg, L.R., Goodman, J.E., Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?. Regul. Toxicol. Pharmacol. 64 (2012), 130–133.
7. Rhomberg, L.R., Goodman, J.E., Haber, L.T., Dourson, M., Andersen, M.E., Klaunig, J.E., Meek, B., Price, P.S., McClellan, R.O., Cohen, S.M., Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule. Crit. Rev. Toxicol. 41 (2011), 1–19.
8. Sheehan, D.M., No-threshold dose-response curves for nongenotoxic chemicals: findings and applications for risk assessment. Environ. Res. 100 (2006), 93–99.
9. Vandenberg, L.N., Colborn, T., Hayes, T.B., Heindel, J.J., Jacobs, D.R. Jr., Lee, D.H., Shioda, T., Soto, A.M., vom Saal, F.S., Welshons, W.V., Zoeller, R.T., Myers, J.P., Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr. Rev. 33 (2012), 378–455.
10. Zoeller, R.T., Brown, T.R., Doan, L.L., Gore, A.C., Skakkebaek, N.E., Soto, A.M., Woodruff, T.J., Vom Saal, F.S., Endocrine-disrupting chemicals and public health protection: a statement of principles from the endocrine society. Endocrinology 153 (2012), 4097–4110.