Lack of a pharmacokinetic drug-drug interaction between lithium and valproate when co-administered with aripiprazole

Journal of Clinical Pharmacy and Therapeutics

Volumn 37, Issue 5, 2012, Pages 565-570

  Boulton, D W ^a   Kollia, G D ^a   Mallikaarjun, S ^b   Kornhauser, D M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

Author keywords

aripiprazole; bipolar disorder; lithium; pharmacokinetics; valproate; valproic acid

Indexed keywords

ARIPIPRAZOLE; LITHIUM; VALPROIC ACID;

ABDOMINAL PAIN; ADULT; AKATHISIA; ANOREXIA; ANXIETY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG TOLERANCE; FATIGUE; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; INSOMNIA; MALE; NAUSEA; NORMAL HUMAN; NOSE CONGESTION; ORTHOSTATIC HYPOTENSION; SIDE EFFECT; SOMNOLENCE; SORE THROAT; TOOTH PAIN;

EID: 85027927549     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2012.01331.x     Document Type: Article

References (16)

1. Yatham LN, Kennedy SH, Schaffer A, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009. Bipolar Disord, 2009; 11: 225-255.
2. Suppes T, Dennehy EB, Hirschfeld RM, et al. The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder. J Clin Psychiatry, 2005; 66: 870-886. (Pubitemid 41032829)
3. Goodwin GM,. Evidence-based guidelines for treating bipolar disorder: revised second edition-recommendations from the British Association for Psychopharmacology. J Psychopharmacol, 2009; 23: 346-388.
4. Suppes T, Eudicone J, McQuade R, Pikalov A III, Carlson B,. Efficacy and safety of aripiprazole in subpopulations with acute manic or mixed episodes of bipolar I disorder. J Affect Disord, 2008; 107: 145-154. (Pubitemid 351288925)
5. Vieta E, T'joen C, McQuade RD, et al. Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially non-responsive to valproate/lithium monotherapy: a placebo-controlled study. Am J Psychiatry 2008; 165: 1316-1325.
6. Vieta E, Owen R, Baudelet C, et al. Assessment of safety, tolerability and effectiveness of adjunctive aripiprazole to lithium/valproate in bipolar mania: a 46-week, open-label extension following a 6-week double-blind study. Curr Med Res Opin, 2010; 26: 1485-1496.
7. Marcus R, Khan A, Rollin L, et al. Efficacy of aripiprazole adjunctive to lithium or Valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study. Bipolar Disord, 2011; 13: 133-144.
8. Keck PE Jr, Marcus R, Tourkodimitris S, et al. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. Am J Psychiatry, 2003; 160: 1651-1658. (Pubitemid 41079552)
9. Keck PE Jr, Orsulak PJ, Cutler AJ, et al. Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study. J Affect Disord, 2009; 112: 36-49.
10. Sachs G, Sanchez R, Marcus R, et al. Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study. J Psychopharmacol, 2006; 20: 536-546. (Pubitemid 43875183)
11. Young AH, Oren DA, Lowry A, et al. Aripiprazole monotherapy in acute mania: 12-week randomized placebo- and haloperidol-controlled study. Br J Psychiatry, 2009; 194: 40-48.
12. Citrome L, Josiassen R, Bark N, Salazar DE, Mallikaarjun S,. Pharmacokinetics of aripiprazole and concomitant lithium and valproate. J Clin Pharmacol, 2005; 45: 89-93.
13. Abilify Package Insert. Tokyo, Japan: Otsuka Pharmaceutical Co Ltd, 2011.
14. Ward ME, Musa MN, Bailey L,. Clinical pharmacokinetics of lithium. J Clin Pharmacol, 1994; 34: 280-285. (Pubitemid 24138957)
15. Zaccara G, Messori A, Moroni F,. Clinical pharmacokinetics of valproic acid. Clin Pharmacokinet, 1988; 15: 367-389.
16. Schieber FC, Boulton DW, Balch AH, et al. A non-randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady-state pharmacokinetics of lamotrigine in patients with bipolar I disorder. Hum Psychopharmacol Clin Exp, 2009; 24: 145-152.