-
1
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
DOI 10.1371/journal.pmed.0020073, e73
-
W Pao VA Miller KA Politi GJ Riely R Somwar MF Zakowski MG Kris H Varmus 2005 Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med 2 3 e73 15737014 10.1371/journal.pmed.0020073 (Pubitemid 40629469)
-
(2005)
PLoS Medicine
, vol.2
, Issue.3
, pp. 0225-0235
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
2
-
-
0142055937
-
Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients with Non-Small Cell Lung Cancer: A Randomized Trial
-
DOI 10.1001/jama.290.16.2149
-
MG Kris RB Natale RS Herbst TJ Lynch Jr D Prager CP Belani JH Schiller K Kelly H Spiridonidis A Sandler KS Albain D Cella MK Wolf SD Averbuch JJ Ochs AC Kay 2003 Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer JAMA 290 2149 2158 14570950 10.1001/jama.290.16.2149 1:CAS:528: DC%2BD3sXosVOnsbo%3D (Pubitemid 37432975)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
3
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
JG Paez PA Jänne JC Lee S Tracy H Greulich S Gabriel P Herman FJ Kaye N Lindeman TJ Boggon K Naoki H Sasaki Y Fujii MJ Eck WR Sellers BE Johnson M Meyerson 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500 15118125 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
4
-
-
0032518787
-
Bim: A novel member of the Bcl-2 family that promotes apoptosis
-
DOI 10.1093/emboj/17.2.384
-
L O'Connor A Strasser LA O'Reilly G Hausmann JM Adams S Cory DC Huang 1998 Bim: a novel member of the Bcl-2 family that promotes apoptosis EMBO J 17 2 384 395 9430630 10.1093/emboj/17.2.384 (Pubitemid 28045479)
-
(1998)
EMBO Journal
, vol.17
, Issue.2
, pp. 384-395
-
-
O'Connor, L.1
Strasser, A.2
O'Reilly, L.A.3
Hausmann, G.4
Adams, J.M.5
Cory, S.6
Huang, D.C.S.7
-
5
-
-
33644834349
-
Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization
-
DOI 10.1038/sj.onc.1209184, PII 1209184
-
YY He JL Huang CF Chignell 2006 Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization Oncogene 25 1521 1531 16247443 10.1038/sj.onc.1209184 1:CAS:528: DC%2BD28XitFGhtrw%3D (Pubitemid 43361937)
-
(2006)
Oncogene
, vol.25
, Issue.10
, pp. 1521-1531
-
-
He, Y.-Y.1
Huang, J.-L.2
Chignell, C.F.3
-
6
-
-
15744401627
-
The expression of Bcl-2 family proteins differs between nonsmall cell lung carcinoma subtypes
-
DOI 10.1002/cncr.20907
-
HK Berrieman L Smith SL O'Kane 2005 The expression of Bcl-2 family proteins differs between nonsmall cell lung carcinoma subtypes Cancer 103 7 1415 1419 15700269 10.1002/cncr.20907 1:CAS:528:DC%2BD2MXjtFamtr8%3D (Pubitemid 40410737)
-
(2005)
Cancer
, vol.103
, Issue.7
, pp. 1415-1419
-
-
Berrieman, H.K.1
Smith, L.2
O'Kane, S.L.3
Campbell, A.4
Lind, M.J.5
Cawkwell, L.6
-
7
-
-
11144352431
-
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression
-
DOI 10.1016/j.febslet.2004.11.074, PII S001457930401470X
-
M Rosas KU Birkenkamp JW Lammers L Koenderman PJ Coffer 2005 Cytokine mediated suppression of TF-1 apoptosis requires PI3 K activation and inhibition of Bim expression FEBS Lett 579 1 191 198 15620712 10.1016/j.febslet.2004.11.074 1:CAS:528:DC%2BD2cXhtFGht7jE (Pubitemid 40023395)
-
(2005)
FEBS Letters
, vol.579
, Issue.1
, pp. 191-198
-
-
Rosas, M.1
Birkenkamp, K.U.2
Lammers, J.-W.J.3
Koenderman, L.4
Coffer, P.J.5
-
8
-
-
37549001026
-
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
-
18089817 10.1158/0008-5472.CAN-07-1961 1:CAS:528:DC%2BD2sXhsVCjs7nN
-
J Deng T Shimamura S Perera 2007 Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion Cancer Res 67 24 11867 11875 18089817 10.1158/0008-5472.CAN-07-1961 1:CAS:528:DC%2BD2sXhsVCjs7nN
-
(2007)
Cancer Res
, vol.67
, Issue.24
, pp. 11867-11875
-
-
Deng, J.1
Shimamura, T.2
Perera, S.3
-
9
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
P Bouillet D Metcalf DC Huang DM Tarlinton TW Kay F Köntgen JM Adams A Strasser 1999 Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude to immunity Science 286 5445 1735 1738 10576740 10.1126/science.286.5445.1735 1:CAS:528:DyaK1MXnsl2nsLo%3D (Pubitemid 129515880)
-
(1999)
Science
, vol.286
, Issue.5445
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.S.3
Tarlinton, D.M.4
Kay, T.W.H.5
Kontgen, F.6
Adams, J.M.7
Strasser, A.8
-
10
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
DOI 10.1038/415922a
-
P Bouillet JF Purton DI Godfrey LC Zhang L Coultas H Puthalakath M Pellegrini S Cory JM Adams A Strasser 2002 BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes Nature 415 6874 922 926 11859372 10.1038/415922a 1:CAS:528:DC%2BD38Xhs12jt7w%3D (Pubitemid 34174755)
-
(2002)
Nature
, vol.415
, Issue.6874
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
Zhang, L.-C.4
Coultas, L.5
Puthalakath, H.6
Pellegrini, M.7
Cory, S.8
Adams, J.M.9
Strasser, A.10
-
11
-
-
35148815554
-
Bim and the pro-survival Bcl-2 proteins: Opposites attract, ERK repels
-
KE Ewings CM Wiggins SJ Cook 2007 Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels Cell Cycle 6 18 2236 2240 17881896 10.4161/cc.6.18.4728 1:CAS:528:DC%2BD2sXhtlKkt7rE (Pubitemid 47547699)
-
(2007)
Cell Cycle
, vol.6
, Issue.18
, pp. 2236-2240
-
-
Ewings, K.E.1
Wiggins, C.M.2
Cook, S.J.3
-
12
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
-
DOI 10.1371/journal.pmed.0040315
-
DB Costa B Halmos A Kumar ST Schumer MS Huberman TJ Boggon DG Tenen S Kobayashi 2007 BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations PLoS Med 4 10 e315 10.1371/journal.pmed.0040315 (1669-1679) (Pubitemid 350035456)
-
(2007)
PLoS Medicine
, vol.4
, Issue.10
, pp. 1669-1680
-
-
Costa, D.B.1
Halmos, B.2
Kumar, A.3
Schumer, S.T.4
Huberman, M.S.5
Boggon, T.J.6
Tenen, D.G.7
Kobayashi, S.8
-
13
-
-
35648965243
-
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
-
DOI 10.1371/journal.pmed.0040294
-
Y Gong R Somwar K Politi 2007 Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas PLoS Med 4 10 e294 17927446 10.1371/journal.pmed.0040294 (Pubitemid 350035455)
-
(2007)
PLoS Medicine
, vol.4
, Issue.10
, pp. 1655-1668
-
-
Gong, Y.1
Somwar, R.2
Politi, K.3
Balak, M.4
Chmielecki, J.5
Jiang, X.6
Pao, W.7
-
14
-
-
23044514254
-
Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK
-
DOI 10.1038/sj.cdd.4401688
-
R Ley KE Ewings K Hadfield SJ Cook 2005 Regulatory phosphorylation of Bim: sorting out the ERK from the JNK Cell Death Differ 12 1008 1014 15947788 10.1038/sj.cdd.4401688 1:CAS:528:DC%2BD2MXmtVylsr4%3D (Pubitemid 41065418)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.8
, pp. 1008-1014
-
-
Ley, R.1
Ewings, K.E.2
Hadfield, K.3
Cook, S.J.4
-
15
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
-
DOI 10.1371/journal.pmed.0040315
-
DB Costa B Halmos A Kumar ST Schumer MS Huberman TJ Boggon DG Tenen S Kobayashi 2007 BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations PLoS Med 4 1669 1679 17973572 10.1371/journal.pmed.0040315 1:CAS:528:DC%2BD2sXhtl2rt7jF (Pubitemid 350035456)
-
(2007)
PLoS Medicine
, vol.4
, Issue.10
, pp. 1669-1680
-
-
Costa, D.B.1
Halmos, B.2
Kumar, A.3
Schumer, S.T.4
Huberman, M.S.5
Boggon, T.J.6
Tenen, D.G.7
Kobayashi, S.8
-
16
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
DOI 10.1371/journal.pmed.0040316
-
MS Cragg J Kuroda H Puthalakath DC Huang A Strasser 2007 Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics PLoS Med 4 1681 1689 17973573 10.1371/journal.pmed.0040316 1:CAS:528:DC%2BD2sXhtl2rt7nM (Pubitemid 350035457)
-
(2007)
PLoS Medicine
, vol.4
, Issue.10
, pp. 1681-1690
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
Huang, D.C.S.4
Strasser, A.5
-
17
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
DOI 10.1371/journal.pmed.0040316
-
MS Cragg J Kuroda H Puthalakath DC Huang A Strasser 2007 Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM, can be enhanced by BH3 mimetics PLoS Med 4 10 e316 10.1371/journal.pmed. 0040316 (Pubitemid 350035457)
-
(2007)
PLoS Medicine
, vol.4
, Issue.10
, pp. 1681-1690
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
Huang, D.C.S.4
Strasser, A.5
-
18
-
-
85028105912
-
397 POSTER Effects of cisplatin exposure on the expression of Bcl-2-family proteins: Differences between cisplatin-sensitive and -resistant malignant pleural mesothelioma cells
-
10.1016/S1359-6349(07)70415-9
-
V Janson K Grankvist 2007 397 POSTER Effects of cisplatin exposure on the expression of Bcl-2-family proteins: differences between cisplatin-sensitive and -resistant malignant pleural mesothelioma cells Eur J Cancer Suppl 5 4 83 10.1016/S1359-6349(07)70415-9
-
(2007)
Eur J Cancer Suppl
, vol.5
, Issue.4
, pp. 83
-
-
Janson, V.1
Grankvist, K.2
-
19
-
-
33846219461
-
Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death
-
DOI 10.1038/sj.cdd.4401983, PII 4401983
-
Z Li J Zhang Z Liu CW Woo CJ Thiele 2007 Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death Cell Death Differ 14 2 318 326 16778834 10.1038/sj.cdd.4401983 (Pubitemid 46092234)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.2
, pp. 318-326
-
-
Li, Z.1
Zhang, J.2
Liu, Z.3
Woo, C.-W.4
Thiele, C.J.5
-
20
-
-
14944349359
-
Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim
-
DOI 10.1038/sj.cdd.4401554
-
R Li T Moudgil HJ Ross 2005 Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim Cell Death Differ 12 3 292 303 15711598 10.1038/sj.cdd.4401554 1:CAS:528:DC%2BD2MXhtlSrtrY%3D (Pubitemid 40360952)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.3
, pp. 292-303
-
-
Li, R.1
Moudgil, T.2
Ross, H.J.3
Hu, H.-M.4
-
21
-
-
34250843189
-
Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation
-
DOI 10.1016/j.yexcr.2007.04.014, PII S0014482707001875
-
KS Borensztajn F Maarten 2007 Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation Exp Cell Res 313 12 2622 2633 17531220 10.1016/j.yexcr.2007.04.014 1:CAS:528:DC%2BD2sXntFKgu7g%3D (Pubitemid 46977338)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.12
, pp. 2622-2633
-
-
Borensztajn, K.S.1
Bijlsma, M.F.2
Groot, A.P.3
Bruggemann, L.W.4
Versteeg, H.H.5
Reitsma, P.H.6
Peppelenbosch, M.P.7
Spek, C.A.8
-
22
-
-
38349103951
-
Down-regulation of 14-3-3 zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation
-
18162532 10.1073/pnas.0710905105 1:CAS:528:DC%2BD1cXpvFSjsQ%3D%3D
-
Z Li J Zhao Y Du 2008 Down-regulation of 14-3-3 zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation Proc Natl Acad Sci USA 105 1 162 167 18162532 10.1073/pnas.0710905105 1:CAS:528:DC%2BD1cXpvFSjsQ%3D%3D
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.1
, pp. 162-167
-
-
Li, Z.1
Zhao, J.2
Du, Y.3
-
23
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
DOI 10.1016/j.ccr.2006.10.006, PII S1535610806003138
-
M Konopleva R Contractor T Tsao 2006 Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia Cancer Cell 10 5 375 388 17097560 10.1016/j.ccr.2006.10.006 1:CAS:528:DC%2BD28Xht1Glu7nJ (Pubitemid 44693472)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
Deng, X.7
Zhai, D.8
Shi, Y.-X.9
Sneed, T.10
Verhaegen, M.11
Soengas, M.12
Ruvolo, V.R.13
McQueen, T.14
Schober, W.D.15
Watt, J.C.16
Jiffar, T.17
Ling, X.18
Marini, F.C.19
Harris, D.20
Dietrich, M.21
Estrov, Z.22
McCubrey, J.23
May, W.S.24
Reed, J.C.25
Andreeff, M.26
more..
-
25
-
-
27944444486
-
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells
-
DOI 10.1002/ijc.21290
-
ML Janmaat JA Rodriguez M Gallegos-Ruiz FA Kruyt G Giaccone 2006 Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells Int J Cancer 118 209 214 16003751 10.1002/ijc.21290 1:CAS:528:DC%2BD2MXht1KgsrvP (Pubitemid 41681601)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.1
, pp. 209-214
-
-
Janmaat, M.L.1
Rodriguez, J.A.2
Gallegos-Ruiz, M.3
Kruyt, F.A.E.4
Giaccone, G.5
-
26
-
-
20044385081
-
In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury
-
DOI 10.1189/jlb.1004617
-
L Joanne 2005 Lomas-Neira, Chun-Shiang Chung, et al. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury J Leukoc Biol 77 846 853 10.1189/jlb.1004617 (Pubitemid 40770834)
-
(2005)
Journal of Leukocyte Biology
, vol.77
, Issue.6
, pp. 846-853
-
-
Lomas-Neira, J.L.1
Chung, C.-S.2
Wesche, D.E.3
Perl, M.4
Ayala, A.5
|