Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women

Menopause

Volumn 20, Issue 4, 2013, Pages 437-442

  Yamatani, Hizuru ^a   Takahashi, Kazuhiro ^a   Yoshida, Takayuki ^a   Takata, Keiko ^a   Kurachi, Hirohisa ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

11 Hydroxysteroid dehydrogenase; 17 Hydroxysteroid dehydrogenase; Cortisol; Estrogen; Menopause

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTISONE; ESTRADIOL; ESTROGEN; ESTRONE; GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; ELECTIVE SURGERY; FEMALE; GENE EXPRESSION; GYNECOLOGIC SURGERY; HUMAN; INTRAABDOMINAL FAT; LIQUID CHROMATOGRAPHY; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TANDEM MASS SPECTROMETRY;

EID: 85027921676     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0b013e318271a640     Document Type: Article

References (24)

1. Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb 2011;18:629-639.
2. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 2003,88:2404-2411.
3. Peeke PM, Chrousos GP. Hypercortisolism and obesity. Ann N Y Acad Sci 1995;771:665-676.
4. Mattsson C, Reynolds RM, Simonyte K, Olsson T, Walker BR. Combined receptor antagonist stimulation of the hypothalamic-pituitaryadrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men. J Clin Endocrinol Metab 2009;94:1347-1352.
5. Seckl JR, Morton NM, Chapman KE, Walker BR. Glucocorticoids and 11A-hydroxysteroid dehydrogenase in adipose tissue. Recent Prog Horm Res 2004;59:359-393.
6. Morton NM, Paterson JM, Masuzaki H, et al. Novel adipose tissueY mediated resistance to diet-induced visceral obesity in 11A-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004;53:931-938.
7. Masuzaki H, Yamamoto H, Kenyon CJ, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003;112:83-90.
8. Tagawa N, Yuda R, Kubota S, et al. 17A-Estradiol inhibits 11Ahydroxysteroid dehydrogenase type 1 activity in rodent adipocytes. J Endocrinol 2009;202:131-139.
9. Grodin JM, Siiteri PK, MacDonald PC. Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 1973;36:207-214.
10. Xu XF, De Pergola G, Björntorp P. Testosterone increases lipolysis and the number of A-adrenoceptors in male rat adipocytes. Endocrinology 1991;128:379-382.
11. Luu The V, Labrie C, Zhao HF, et al. Characterization of cDNAs for human estradiol 17 A-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Mol Endocrinol 1989;3:1301-1309.
12. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S. Expression cloning and characterization of human 17A-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J Biol Chem 1993;268:12964-12969.
13. Miyoshi Y, Ando A, Shiba E, Taguchi T, Tamaki Y, Noguchi S. Involvement of up-regulation of 17A-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers. Int J Cancer 2001;94:685-689.
14. Corbould AM, Judd SJ, Rodgers RJ. Expression of types 1, 2, and 3 17Ahydroxysteroid dehydrogenase in subcutaneous abdominal and intraabdominal adipose tissue of women. J Clin Endocrinol Metab 1998; 83:187-194.
15. Arai S, Miyashiro Y, Shibata Y, et al. Effect of castration monotherapy on the levels of adrenal androgens in cancerous prostatic tissues. Steroids 2011;76:301-308.
16. Dubuc PU. Effects of estradiol implants on body weight regulation in castrated and intact female rats. Endocrinology 1974;95:1733-1736.
17. Genazzani AR, Gambacciani M. Effect of climacteric transition and hormone replacement therapy on body weight and body fat distribution. Gynecol Endocrinol 2006;22:145-150.
18. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH. Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999;84: 1022-1027.
19. Andersson T, Simonyte K, Andrew R, et al. Tissue-specific increases in 11A-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women. PLoS One 2009;4:e8475.
20. Wake DJ, Strand M, Rask E, et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol 2007;66:440-446.
21. Misso ML, Jang C, Adams J, et al. Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy. Menopause 2005;12:210-215.
22. Sasano H, Suzuki T, Miki Y, Moriya T. Intracrinology of estrogens and androgens in breast carcinoma. J Steroid Biochem Mol Biol 2008;108: 181-185.
23. Miettinen MM, Mustonen MV, Poutanen MH, Isomaa VV, Vihko RK. Human 17A-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic celland tissue-specific expression. Biochem J 1996;314:839-845.
24. Utsunomiya H, Suzuki T, Kaneko C, et al. The analyses of 17Ahydroxysteroid dehydrogenase isozymes in human endometrial hyperplasia and carcinoma. J Clin Endocrinol Metab 2001;86:3436-3443.