The Identification of a Novel Highly Condensed Pentacyclic Heteroaromatic Ring System 1,3,5,5b,6,8,10,10b‐Octaazacyclopenta[h,i]Aceanthrylene and its Application in the Synthesis of 5,7‐Substituted Pyrazolo[4,3‐d]Pyrimidines

Journal of Heterocyclic Chemistry

Volumn 52, Issue 3, 2015, Pages 669-673

  Havlíček, Libor ^a   Moravcová, Daniela ^a   Kryštof, Vladimír ^a   Strnad, Miroslav ^a  

^a INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

Author keywords

5,11 dichloro 1,7 diisopropyldipyrazolo 4,3,2 d,e; 4,3,2 k,l pyrimido 4,5 g pteridine ; fluorescence; kinase inhibitor; pyrazolo 4,3 d pyrimidine; roscovitine

Indexed keywords

1,3,5,5B,6,8,10,10B OCTAAZACYCLOPENTA[H,I]ACEANTHRYLENE; 4,9 DICHLORO 2,7 DIISOPROPYL 1,3,5,5B,6,8,10,10B OCTAAZACYCLOPENTA[H,I]ACEANTHRYLENE; AROMATIC COMPOUND; BENZYLAMINE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOPENTANE DERIVATIVE; N BENZYL 5 CHLORO 3 ISOPROPYL 1H PYRAZOLO[4,3 D]PYRIDIMIN 7 AMINE; PYRAZOLO[4,3 D]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; ROSCOVITINE; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS;

EID: 85027921177     PISSN: 0022152X     EISSN: 19435193     Source Type: Journal    
DOI: 10.1002/jhet.2147     Document Type: Article

References (18)

1. Zhang, J., Yang, P.L., Gray, N.S., Nat Rev Cancer, 9, 2009, 28.
2. Fedorov, O., Müller, S., Knapp, S., Nat Chem Biol, 6, 2010, 166.
3. Krystof, V., Uldrijan, S., Curr Drug Targets, 11, 2010, 291.
4. Malumbres, M., Barbacid, M., Nat Rev Cancer, 9, 2009, 153.
5. Havlicek, L., Hanus, J., Vesely, J., LeClerc, S., Meijer, L., Shaw, G., Strnad, M., J Med Chem, 40, 1997, 408.
6. Krystof, V., McNae, I.W., Walkinshaw, M.D., Fischer, P.M., Muller, P., Vojtesek, B., Orsag, M., Havlicek, L., Strnad, M., Cell Mol Life Sci, 62, 2005, 1763.
7. Zatloukal, M., Jorda, R., Gucky, T., Reznickova, E., Voller, J., Pospisil, T., Malinková, V., Adamcova, H., Krystof, V., Strnad, M., Eur J Med Chem, 61, 2013, 61.
8. Jorda, R., Paruch, K., Krystof, V., Curr Pharm Des, 18, 2012, 2974.
9. Paruch, K., Dwyer, M.P., Alvarez, C., Brown, C., Chan, T.Y., Doll, R.J., Keertikar, K., Knutson, C., McKittrick, B., Rivera, J., Rossman, R., Tucker, G., Fischmann, T.O., Hruza, A., Madison, V., Nomeir, A.A., Wang, Y., Lees, E., Parry, D., Sgambellone, N., Seghezzi, W., Schultz, L., Shanahan, F., Wiswell, D., Xu, X., Zhou, Q., James, R.A., Paradkar, V.M., Park, H., Rokosz, L.R., Stauffer, T.M., Guzi, T.J., Bioorg Med Chem Lett, 17, 2007, 6220.
10. Krystof, V., Moravcova, D., Paprskarova, M., Barbier, P., Peyrot, V., Hlobilkova, A., Havlicek, L., Strnad, M., Eur J Med Chem, 41, 2006, 1405.
11. Elion, G.B., Hitchins, G.H., J Am Chem Soc, 78, 1956, 3508.
12. Gupta, P.K., Bhakuni, D.S., Ind J Chem, 20B, 1981, 534.
13. Moravec, J., Krystof, V., Hanus, J., Havlicek, L., Moravcova, D., Fuksova, K., Kuzma, M., Lenobel, R., Otyepka, M., Strnad, M., Bioorg Med Chem Lett, 13, 2003, 2993.
14. Jorda, R., Havlicek, L., McNae, I.W., Walkinshaw, M.D., Voller, J., Sturc, A., Navratilova, J., Kuzma, M., Mistrik, M., Bartek, J., Strnad, M., Krystof, V., J Med Chem, 54, 2011, 2980.
15. Jorda, R., Sacerdoti‐Sierra, N., Voller, J., Havlicek, L., Kracalikova, K., Nowicki, M.W., Nasereddin, A., Krystof, V., Strnad, M., Walkinshaw, M.D., Jaffe, C.L., Bioorg Med Chem Lett, 21, 2011, 4233.
16. Sroka, I.M., Heiss, E.H., Havlicek, L., Totzke, F., Aristei, Y., Pechan, P., Kubbutat, M.H., Strnad, M., Dirsch, V.M., Mol Pharmacol, 77, 2010, 255.
17. Wang, K., Hampson, P., Hazeldine, J., Krystof, V., Strnad, M., Pechan, P., Lord, M.J., PLoS One, 7, 2012.
18. Weitensteiner, S.B., Liebl, J., Krystof, V., Havlicek, L., Gucky, T., Strnad, M., Fürst, R., Vollmar, A.M., Zahler, S., PLoS One, 8, 2013.