Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

Journal of Neuro-Oncology

Volumn 105, Issue 2, 2011, Pages 191-198

  Nageswara Rao, Amulya A ^a,b   Ye, Hong ^a   Decker, Paul A ^a   Howe, Charles L ^a   Wetmore, Cynthia ^a,c  

^a MAYO CLINIC   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Fractionated cranial irradiation; Hippocampus dependent non spatial memory; Neurogenesis, dentate gyrus; Novel location recognition; Pediatric brain tumors

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN DEVELOPMENT; CANCER RADIOTHERAPY; CELL COUNT; CELL PROLIFERATION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IONIZING RADIATION; LEARNING DISORDER; MALE; MENTAL TASK; MOUSE; NEURAL STEM CELL; NEUROBLAST; NEUROTOXICITY; NONHUMAN; RADIATION DOSE; RADIATION INJURY; STEM CELL NICHE; TASK PERFORMANCE;

EID: 85027918249     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-011-0582-9     Document Type: Article

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