메뉴 건너뛰기




Volumn 28, Issue 8, 2017, Pages 1713-1729

Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials

Author keywords

Anti EGFR treatment; Colorectal cancer; Predictive value; Prognostic; Randomized trial; Tumour side

Indexed keywords

BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

EID: 85027706884     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdx175     Document Type: Article
Times cited : (690)

References (58)
  • 1
    • 0037140197 scopus 로고    scopus 로고
    • Left and right sided large bowel cancer
    • Richman S, Adlard J. Left and right sided large bowel cancer. Br Med J 2002; 324: 931-932
    • (2002) Br Med J , vol.324 , pp. 931-932
    • Richman, S.1    Adlard, J.2
  • 2
    • 84873270711 scopus 로고    scopus 로고
    • Possible better long-term survival in left versus rightsided colon cancer-a systematic review
    • Hansen IO, Jess P. Possible better long-term survival in left versus rightsided colon cancer-a systematic review. Dan Med J 2012; 59: A4444
    • (2012) Dan Med J , vol.59 , pp. A4444
    • Hansen, I.O.1    Jess, P.2
  • 3
    • 77954361808 scopus 로고    scopus 로고
    • Colorectal cancer incidence trends in the United States and United Kingdom: evidence of right-to left-sided biological gradients with implications for screening
    • Meza R, Jeon J, Renehan AG, Luebeck EG. Colorectal cancer incidence trends in the United States and United Kingdom: evidence of right-to left-sided biological gradients with implications for screening. Cancer Res 2010; 70: 5419-5429
    • (2010) Cancer Res , vol.70 , pp. 5419-5429
    • Meza, R.1    Jeon, J.2    Renehan, A.G.3    Luebeck, E.G.4
  • 4
    • 85029295140 scopus 로고    scopus 로고
    • Differences in outcome between right-and left-sided colon cancer: a population based study
    • Aarts F, de Hingh I, de Wilt JHW et al. Differences in outcome between right-and left-sided colon cancer: a population based study. J Clin Oncol 2013; 31(suppl 4): Abstract 493
    • (2013) J Clin Oncol , vol.31
    • Aarts, F.1    de Hingh, I.2    de Wilt, J.H.W.3
  • 5
    • 84860740469 scopus 로고    scopus 로고
    • Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis
    • Verhulst J, Ferdinande L, Demetter P, Ceelen W. Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis. J Clin Pathol 2012; 65: 381-388
    • (2012) J Clin Pathol , vol.65 , pp. 381-388
    • Verhulst, J.1    Ferdinande, L.2    Demetter, P.3    Ceelen, W.4
  • 6
    • 84872921463 scopus 로고    scopus 로고
    • Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
    • Domingo E, Ramamoorthy R, Oukrif D et al. Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. J Pathol 2013; 229: 441-448
    • (2013) J Pathol , vol.229 , pp. 441-448
    • Domingo, E.1    Ramamoorthy, R.2    Oukrif, D.3
  • 7
    • 67650721735 scopus 로고    scopus 로고
    • A comparison of colon and rectal somatic DNA alterations
    • Slattery ML, Curtin K, Wolff RK et al. A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum 2009; 52: 1304-1311
    • (2009) Dis Colon Rectum , vol.52 , pp. 1304-1311
    • Slattery, M.L.1    Curtin, K.2    Wolff, R.K.3
  • 8
    • 84880709088 scopus 로고    scopus 로고
    • Gene expression profiles and tumor locations in colorectal cancer (left vs. right vs. rectum)
    • Maus MKH, Hanna DL, Stephens C et al. Gene expression profiles and tumor locations in colorectal cancer (left vs. right vs. rectum). J Clin Oncol 2013; 31(suppl 15): Abstract 3527
    • (2013) J Clin Oncol , vol.31
    • Maus, M.K.H.1    Hanna, D.L.2    Stephens, C.3
  • 9
    • 84922536963 scopus 로고    scopus 로고
    • Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features
    • Missiaglia E, Jacobs B, D'Ario G et al. Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol 2014; 25: 1995-2001
    • (2014) Ann Oncol , vol.25 , pp. 1995-2001
    • Missiaglia, E.1    Jacobs, B.2    D'Ario, G.3
  • 10
    • 41349091456 scopus 로고    scopus 로고
    • Map of differential transcript expression in the normal human large intestine
    • LaPointe LC, Dunne R, Brown GS et al. Map of differential transcript expression in the normal human large intestine. Physiol Genomics 2008; 33: 50-64
    • (2008) Physiol Genomics , vol.33 , pp. 50-64
    • LaPointe, L.C.1    Dunne, R.2    Brown, G.S.3
  • 11
  • 12
    • 84984985398 scopus 로고    scopus 로고
    • ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
    • Van Cutsem E, Cervantes A, Adam R et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 2016; 27: 1386-1422
    • (2016) Ann Oncol , vol.27 , pp. 1386-1422
    • Van Cutsem, E.1    Cervantes, A.2    Adam, R.3
  • 13
    • 84946571753 scopus 로고    scopus 로고
    • The consensus molecular subtypes of colorectal cancer
    • Guinney J, Dienstmann R, Wang X et al. The consensus molecular subtypes of colorectal cancer. Nat Med 2015; 21: 1350-1356
    • (2015) Nat Med , vol.21 , pp. 1350-1356
    • Guinney, J.1    Dienstmann, R.2    Wang, X.3
  • 14
    • 84929008294 scopus 로고    scopus 로고
    • Sex-and gender-specific disparities in colorectal cancer risk
    • Kim SE, Paik HY, Yoon H et al. Sex-and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 2015; 21: 5167-5175
    • (2015) World J Gastroenterol , vol.21 , pp. 5167-5175
    • Kim, S.E.1    Paik, H.Y.2    Yoon, H.3
  • 15
    • 84860589077 scopus 로고    scopus 로고
    • Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    • Yamauchi M, Morikawa T, Kuchiba A et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012; 61: 847-854
    • (2012) Gut , vol.61 , pp. 847-854
    • Yamauchi, M.1    Morikawa, T.2    Kuchiba, A.3
  • 16
    • 84942239755 scopus 로고    scopus 로고
    • Primary tumor location as a prognostic factor in metastatic colorectal cancer
    • Loupakis F, Yang D, Yau L et al. Primary tumor location as a prognostic factor in metastatic colorectal cancer. J Natl Cancer Inst 2015; 107: dju427
    • (2015) J Natl Cancer Inst , vol.107
    • Loupakis, F.1    Yang, D.2    Yau, L.3
  • 17
    • 85084273299 scopus 로고    scopus 로고
    • MiR-31-3p is a predictive biomarker of cetuximab response in the FIRE-3 trial
    • Laurent-Puig P, Grisoni M-L, Heinemann V et al. MiR-31-3p is a predictive biomarker of cetuximab response in the FIRE-3 trial. Ann Oncol 2016; 27(suppl 6): Abstract 457o
    • (2016) Ann Oncol , vol.27
    • Laurent-Puig, P.1    Grisoni, M.-L.2    Heinemann, V.3
  • 18
    • 0037057510 scopus 로고    scopus 로고
    • Are there two sides to colorectal cancer?
    • Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer 2002; 101: 403-408
    • (2002) Int J Cancer , vol.101 , pp. 403-408
    • Iacopetta, B.1
  • 19
    • 84891890447 scopus 로고    scopus 로고
    • Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment)
    • Modest DP, Schulz C, von Weikersthal LF et al. Outcome of patients with metastatic colorectal cancer depends on the primary tumor site (midgut vs. hindgut): analysis of the FIRE1-trial (FuFIRI or mIROX as first-line treatment). Anticancer Drugs 2014; 25: 212-218
    • (2014) Anticancer Drugs , vol.25 , pp. 212-218
    • Modest, D.P.1    Schulz, C.2    von Weikersthal, L.F.3
  • 20
    • 85029314061 scopus 로고    scopus 로고
    • Primary tumour location (PTL) as a prognostic and predictive factor in advanced colorectal cancer: data from 20175 patients in randomised trials
    • Seligmann JF., Elliott F, Richman SD et al. Primary tumour location (PTL) as a prognostic and predictive factor in advanced colorectal cancer: data from 20175 patients in randomised trials. Ann Oncol 2014; 25 (suppl 4): iv172
    • (2014) Ann Oncol , vol.25
    • Seligmann, J.F.1    Elliott, F.2    Richman, S.D.3
  • 21
    • 84940720402 scopus 로고    scopus 로고
    • A prognostic analysis of 895 cases of stage III colon cancer in different colon subsites
    • Zhang Y, Ma J, Zhang S et al. A prognostic analysis of 895 cases of stage III colon cancer in different colon subsites. Int J Colorectal Dis 2015; 30: 1173-1183
    • (2015) Int J Colorectal Dis , vol.30 , pp. 1173-1183
    • Zhang, Y.1    Ma, J.2    Zhang, S.3
  • 22
    • 85018200927 scopus 로고    scopus 로고
    • Prognostic survival associated with left-sided vs right-sided colon cancer: a systematic review and metaanalysis
    • Petrelli F, Tomasello G, Borgonovo K et al. Prognostic survival associated with left-sided vs right-sided colon cancer: a systematic review and metaanalysis. JAMA Oncol 2016. DOI: 10.1001/jamaoncol.2016.4227
    • (2016) JAMA Oncol
    • Petrelli, F.1    Tomasello, G.2    Borgonovo, K.3
  • 23
    • 84919884555 scopus 로고    scopus 로고
    • Microbiota organization is a distinct feature of proximal colorectal cancers
    • Dejea CM, Wick EC, Hechenbleikner EM et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci USA 2014; 111: 18321-18326
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 18321-18326
    • Dejea, C.M.1    Wick, E.C.2    Hechenbleikner, E.M.3
  • 24
    • 84930804509 scopus 로고    scopus 로고
    • Location of colon cancer (rightsided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17
    • Brule SY, Jonker DJ, Karapetis CS et al. Location of colon cancer (rightsided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. Eur J Cancer 2015; 51: 1405-1414
    • (2015) Eur J Cancer , vol.51 , pp. 1405-1414
    • Brule, S.Y.1    Jonker, D.J.2    Karapetis, C.S.3
  • 25
    • 84981557065 scopus 로고    scopus 로고
    • Location of primary tumor and benefit from anti-epidermal growth factor receptor monoclonal antibodies in patients with RAS and BRAF wild-type metastatic colorectal cancer
    • Moretto R, Cremolini C, Rossini D et al. Location of primary tumor and benefit from anti-epidermal growth factor receptor monoclonal antibodies in patients with RAS and BRAF wild-type metastatic colorectal cancer. Oncologist 2016; 21: 988-994
    • (2016) Oncologist , vol.21 , pp. 988-994
    • Moretto, R.1    Cremolini, C.2    Rossini, D.3
  • 26
    • 84970016836 scopus 로고    scopus 로고
    • Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a mationwide cohort study
    • Chen K-H, Shao Y-Y, Chen H-M et al. Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a mationwide cohort study. BMC Cancer 2016; 16: 327
    • (2016) BMC Cancer , vol.16 , pp. 327
    • Chen, K.-H.1    Shao, Y.-Y.2    Chen, H.-M.3
  • 27
    • 84983782183 scopus 로고    scopus 로고
    • Impact of primary tumor location on overall suvival (OS) and progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC): analysis of CALGB/SWOG 80405 (Alliance)
    • Venook A, Niedzwiecki D, Innocenti F et al. Impact of primary tumor location on overall suvival (OS) and progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC): analysis of CALGB/SWOG 80405 (Alliance). J Clin Oncol 2016; 34 (suppl): Abstract 3504
    • (2016) J Clin Oncol , vol.34
    • Venook, A.1    Niedzwiecki, D.2    Innocenti, F.3
  • 28
    • 85011577233 scopus 로고    scopus 로고
    • Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer: Retrospective analyses of the CRYSTAL and FIRE-3 trials
    • Tejpar S, Stintzing S, Ciardiello F et al. Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer: Retrospective analyses of the CRYSTAL and FIRE-3 trials. JAMA Oncol 2016. DOI: 10.1001/jamaoncol.2016.4227
    • (2016) JAMA Oncol
    • Tejpar, S.1    Stintzing, S.2    Ciardiello, F.3
  • 29
    • 73449128751 scopus 로고    scopus 로고
    • Comparison of 17,641 patients with right-and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival
    • Benedix F, Kube R, Meyer F et al. Comparison of 17,641 patients with right-and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum 2010; 53: 57-64
    • (2010) Dis Colon Rectum , vol.53 , pp. 57-64
    • Benedix, F.1    Kube, R.2    Meyer, F.3
  • 30
    • 84992138803 scopus 로고    scopus 로고
    • The relationship between primary tumor sidedness and prognosis in colorectal cancer
    • Schrag D, Weng S, Brooks G et al. The relationship between primary tumor sidedness and prognosis in colorectal cancer. J Clin Oncol 2016; 34(suppl): Abstract 3505
    • (2016) J Clin Oncol , vol.34
    • Schrag, D.1    Weng, S.2    Brooks, G.3
  • 31
    • 84884722908 scopus 로고    scopus 로고
    • Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer
    • Boisen MK, Johansen JS, Dehlendorff C et al. Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer. Ann Oncol 2013; 24: 2554-2559
    • (2013) Ann Oncol , vol.24 , pp. 2554-2559
    • Boisen, M.K.1    Johansen, J.S.2    Dehlendorff, C.3
  • 32
    • 84960968937 scopus 로고    scopus 로고
    • Impact of primary tumor site on bevacizumab efficacy in metastatic colorectal cancer
    • Wong HL, Lee B, Field K et al. Impact of primary tumor site on bevacizumab efficacy in metastatic colorectal cancer. Clin Colorectal Cancer 2016; 15: e9-e15
    • (2016) Clin Colorectal Cancer , vol.15 , pp. e9-e15
    • Wong, H.L.1    Lee, B.2    Field, K.3
  • 33
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-1417
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 34
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
    • Douillard JY, Siena S, Cassidy J et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010; 28: 4697-4705
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 35
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wildtype KRAS exon 2 metastatic colorectal cancer
    • Schwartzberg LS, Rivera F, Karthaus M et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wildtype KRAS exon 2 metastatic colorectal cancer. J Clin Oncol 2014; 32: 2240-2247
    • (2014) J Clin Oncol , vol.32 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3
  • 36
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial
    • Heinemann V, von Weikersthal LF, Decker T et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 2014; 15: 1065-1075
    • (2014) Lancet Oncol , vol.15 , pp. 1065-1075
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3
  • 37
    • 84992317442 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab for metastatic colorectal cancer (FIRE-3): a post-hoc analysis of tumour dynamics in the final RAS wild-type subgroup of this randomised open-label phase 3 trial
    • Stintzing S, Modest DP, Rossius L et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab for metastatic colorectal cancer (FIRE-3): a post-hoc analysis of tumour dynamics in the final RAS wild-type subgroup of this randomised open-label phase 3 trial. Lancet Oncol 2016; 17: 1426-1434
    • (2016) Lancet Oncol , vol.17 , pp. 1426-1434
    • Stintzing, S.1    Modest, D.P.2    Rossius, L.3
  • 38
    • 84907027361 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/ leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
    • abstract LBA 3
    • Venook A, Niedzwiecki D, Lenz HJ et al. CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/ leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC). J Clin Oncol 2014; 32(suppl 15): abstract LBA 3
    • (2014) J Clin Oncol , vol.32
    • Venook, A.1    Niedzwiecki, D.2    Lenz, H.J.3
  • 39
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
    • Peeters M, Price TJ, Cervantes A et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28: 4706-4713
    • (2010) J Clin Oncol , vol.28 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 40
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011; 377: 2103-2114
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 41
    • 84930047088 scopus 로고    scopus 로고
    • FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer
    • Bokemeyer C, Kohne CH, Ciardiello F et al. FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer. Eur J Cancer 2015; 51: 1243-1252
    • (2015) Eur J Cancer , vol.51 , pp. 1243-1252
    • Bokemeyer, C.1    Kohne, C.H.2    Ciardiello, F.3
  • 42
    • 84880736194 scopus 로고    scopus 로고
    • Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases
    • Ye LC, Liu TS, Ren L et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol 2013; 31: 1931-1938
    • (2013) J Clin Oncol , vol.31 , pp. 1931-1938
    • Ye, L.C.1    Liu, T.S.2    Ren, L.3
  • 43
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard JY, Oliner KS, Siena S et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013; 369: 1023-1034
    • (2013) N Engl J Med , vol.369 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 44
    • 84903694472 scopus 로고    scopus 로고
    • Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
    • Douillard JY, Siena S, Cassidy J et al. Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Ann Oncol 2014; 25: 1346-1355
    • (2014) Ann Oncol , vol.25 , pp. 1346-1355
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 45
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011; 29: 2011-2019
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 46
    • 84925324704 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer
    • Van Cutsem E, Lenz HJ, Kohne CH et al. Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol 2015; 33: 692-700
    • (2015) J Clin Oncol , vol.33 , pp. 692-700
    • Van Cutsem, E.1    Lenz, H.J.2    Kohne, C.H.3
  • 47
    • 84875742535 scopus 로고    scopus 로고
    • Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab
    • Peeters M, Douillard JY, Van Cutsem E et al. Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab. J Clin Oncol 2013; 31: 759-765
    • (2013) J Clin Oncol , vol.31 , pp. 759-765
    • Peeters, M.1    Douillard, J.Y.2    Van Cutsem, E.3
  • 48
    • 84954163383 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer
    • Peeters M, Oliner KS, Price TJ et al. Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer. Clin Cancer Res 2015; 21: 5469-5479
    • (2015) Clin Cancer Res , vol.21 , pp. 5469-5479
    • Peeters, M.1    Oliner, K.S.2    Price, T.J.3
  • 49
    • 84937204003 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/ leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded RAS analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC)
    • Lenz HJ, Niedzwiecki D, Innocenti F et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/ leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded RAS analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC). Ann Oncol 2014; 25(suppl 4): Abstract 501o
    • (2014) Ann Oncol , vol.25
    • Lenz, H.J.1    Niedzwiecki, D.2    Innocenti, F.3
  • 50
    • 84995684223 scopus 로고    scopus 로고
    • Outcome according to KRAS-, NRAS-and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group
    • Modest DP, Ricard I, Heinemann V et al. Outcome according to KRAS-, NRAS-and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group. Ann Oncol 2016; 27: 1746-1753
    • (2016) Ann Oncol , vol.27 , pp. 1746-1753
    • Modest, D.P.1    Ricard, I.2    Heinemann, V.3
  • 51
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-1558
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 52
    • 79960838960 scopus 로고    scopus 로고
    • A critical review of methods for the assessment of patient-level interactions in individual participant data meta-analysis of randomized trials, and guidance for practitioners
    • Fisher DJ, Copas AJ, Tierney JF, Parmar MK. A critical review of methods for the assessment of patient-level interactions in individual participant data meta-analysis of randomized trials, and guidance for practitioners. J Clin Epidemiol 2011; 64: 949-967
    • (2011) J Clin Epidemiol , vol.64 , pp. 949-967
    • Fisher, D.J.1    Copas, A.J.2    Tierney, J.F.3    Parmar, M.K.4
  • 53
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25: 3230-3237
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 54
    • 84999098883 scopus 로고    scopus 로고
    • The relevance of primary tumour location in patients with metastatic colorectal cancer: a meta-analysis of first-line clinical trials
    • Holch JW, Ricard I, Stintzing S et al. The relevance of primary tumour location in patients with metastatic colorectal cancer: a meta-analysis of first-line clinical trials. Eur J Cancer 2017; 70: 87-98
    • (2017) Eur J Cancer , vol.70 , pp. 87-98
    • Holch, J.W.1    Ricard, I.2    Stintzing, S.3
  • 55
    • 84868104706 scopus 로고    scopus 로고
    • The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus
    • Adam R, De Gramont A, Figueras J et al. The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist 2012; 17: 1225-1239
    • (2012) Oncologist , vol.17 , pp. 1225-1239
    • Adam, R.1    De Gramont, A.2    Figueras, J.3
  • 56
    • 84939475603 scopus 로고    scopus 로고
    • Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC)
    • Heinemann V, Stintzing S, Modest DP et al. Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC). Eur J Cancer 2015; 51: 1927-1936
    • (2015) Eur J Cancer , vol.51 , pp. 1927-1936
    • Heinemann, V.1    Stintzing, S.2    Modest, D.P.3
  • 57
    • 84953856186 scopus 로고    scopus 로고
    • FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study
    • Cremolini C, Loupakis F, Antoniotti C et al. FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study. Lancet Oncol 2015; 16: 1306-1315
    • (2015) Lancet Oncol , vol.16 , pp. 1306-1315
    • Cremolini, C.1    Loupakis, F.2    Antoniotti, C.3
  • 58
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study
    • Bokemeyer C, Bondarenko I, Hartmann JT et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 2011; 22: 1535-1546
    • (2011) Ann Oncol , vol.22 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.