Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Science

Volumn 357, Issue 6357, 2017, Pages 1303-1307

  Niu, Dong ^a,b   Wei, Hong Jiang ^c   Lin, Lin ^d   George, Haydy ^a   Wang, Tao ^a   Lee, I Hsiu ^a   Zhao, Hong Ye ^c   Wang, Yong ^e   Kan, Yinan ^a   Shrock, Ellen ^f   Lesha, Emal ^a   Wang, Gang ^a   Luo, Yonglun ^d   Qing, Yubo ^c   Jiao, Deling ^c   Zhao, Heng ^c   Zhou, Xiaoyang ^e   Wang, Shouqi ^g   Wei, Hong ^e   Güell, Marc ^a   Church, George M ^a,f,h   Yang, Luhan ^a   more..

^a eGenesis Inc   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c YUNNAN AGRICULTURAL UNIVERSITY   (China)

^d AARHUS UNIVERSITY   (Denmark)

^e THIRD MILITARY MEDICAL UNIVERSITY   (China)

^f HARVARD MEDICAL SCHOOL   (United States)

^g Shenzhen Jinxinnong Technology Co   (China)

^h HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS AND CELL COMPONENTS; DISEASE TRANSMISSION; ENZYME; GENETIC ENGINEERING; IMMUNE SYSTEM; INHIBITION; PIG; RNA; VIRUS;

ANIMAL CELL; ARTICLE; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PIG; PORCINE ENDOGENOUS RETROVIRUS; PRIMARY CELL LINE; PRIORITY JOURNAL; SOMATIC CELL; VIRUS INACTIVATION; VIRUS TRANSMISSION; ANIMAL; CRISPR CAS SYSTEM; DISEASE TRANSMISSION; ENDOGENOUS RETROVIRUS; GENE EDITING; GENETICS; HEK293 CELL LINE; PREVENTION AND CONTROL; PROCEDURES; RETROVIRUS INFECTION; TRANSMISSION; VIROLOGY; XENOGRAFT;

ANIMALIA; PORCINE ENDOGENOUS RETROVIRUS; SUIDAE; SUS;

ANIMALS; CRISPR-CAS SYSTEMS; DISEASE TRANSMISSION, INFECTIOUS; ENDOGENOUS RETROVIRUSES; GENE EDITING; HEK293 CELLS; HUMANS; RETROVIRIDAE INFECTIONS; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 85027324183     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan4187     Document Type: Article

References (11)

1. D. Shafran, E. Kodish, A. Tzakis, World J. Surg. 38, 1650–1657 (2014).
2. J.-Y. Deschamps, F. A. Roux, P. Saï, E. Gouin, Xenotransplantation 12, 91–109 (2005).
3. C. Patience, Y. Takeuchi, R. A. Weiss, Nat. Med. 3, 282–286 (1997).
4. J. Denner, Viruses 8, 215 (2016).
5. L. Yang et al., Science 350, 1101–1104 (2015).
6. Y. Moalic, Y. Blanchard, H. Félix, A. Jestin, J. Virol. 80, 10980–10988 (2006).
7. M. Bendinelli, D. Matteucci, H. Friedman, Adv. Cancer Res. 45, 125–181 (1985).
8. L. J. Wegman-Points et al., Redox Biol. 2, 847–854 (2014).
9. C. Patience et al., J. Virol. 75, 2771–2775 (2001).
10. J. Zhao, J. Whyte, R. S. Prather, Cell Tissue Res. 341, 13–21 (2010).
11. M. A. M. Groenen et al., Nature 491, 393–398 (2012).