Human cytomegalovirus IE2 protein disturbs brain development by the dysregulation of neural stem cell maintenance and the polarization of migrating neurons

Journal of Virology

Volumn 91, Issue 17, 2017, Pages

  Han, Dasol ^a   Byun, Sung Hyun ^a   Kim, Juwan ^a   Kwon, Mookwang ^a   Pleasure, Samuel J ^b   Ahn, Jin Hyun ^c   Yoon, Keejung ^a  

^a Sungkyunkwan University   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Brain development; HCMV; Neural stem cells

Indexed keywords

IMMEDIATE EARLY 2 PROTEIN; IMMEDIATE EARLY PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; IE2 PROTEIN, CYTOMEGALOVIRUS; MEMBRANE PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL CYCLE ARREST; CELL MIGRATION; CELL PROLIFERATION; CELL RENEWAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORPUS CALLOSUM; CYTOMEGALOVIRUS INFECTION; ELECTROPORATION; EMBRYO; FEMALE; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; MORPHOLOGY; MOUSE; NEURAL STEM CELL; NONHUMAN; PATHOGENESIS; POLARIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; ANIMAL; BRAIN; CELL CYCLE CHECKPOINT; CYTOLOGY; CYTOMEGALOVIRUS; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PREGNANCY; VIROLOGY; VIRUS GENE; VIRUS REPLICATION;

ANIMALS; BRAIN; CELL CYCLE CHECKPOINTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA-BINDING PROTEINS; FEMALE; GENES, VIRAL; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; NEURAL STEM CELLS; NEURONS; PREGNANCY; TRANS-ACTIVATORS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 85027317231     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00799-17     Document Type: Article

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