Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex

Science

Volumn 357, Issue 6351, 2017, Pages 600-604

  Luo, Chongyuan ^a,b   Keown, Christopher L ^c   Kurihara, Laurie ^d   Zhou, Jingtian ^a,e   He, Yupeng ^a,e   Li, Junhao ^c   Castanon, Rosa ^a   Lucero, Jacinta ^a   Nery, Joseph R ^a   Sandoval, Justin P ^a   Bui, Brian ^a   Sejnowski, Terrence J ^a,b,f   Harkins, Timothy T ^d   Mukamel, Eran A ^c   Behrens, M Margarita ^a   Ecker, Joseph R ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Swift Bioscience   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADARB2 PROTEIN; ADGRA3 PROTEIN; BIOLOGICAL MARKER; CUX2 PROTEIN; DEPTOR PROTEIN; GABA TRANSPORTER 1; GAD1 PROTEIN; LHX6 PROTEIN; MYOCYTE ENHANCER FACTOR 2; NUCLEAR FACTOR I; PARVALBUMIN; PROTEIN BCL 6; PROTEIN FOS; RETINOID RELATED ORPHAN RECEPTOR BETA; SATB2 PROTEIN; SULF1 PROTEIN; TLE4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARX; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR LHX6; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR POU3; TRANSCRIPTION FACTOR POU6; TRANSCRIPTION FACTOR SOX; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; UPSTREAM STIMULATORY FACTOR; 5 METHYLCYTOSINE; CYTOSINE;

BIOASSAY; BRAIN; CELLS AND CELL COMPONENTS; DNA; GENETIC ANALYSIS; GENOMICS; MAMMAL; PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; BRAIN CELL; CELL SPECIFICITY; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FLUORESCENCE ACTIVATED CELL SORTING; FRONTAL CORTEX; GENETIC CONSERVATION; HUMAN; HUMAN CELL; INTERNEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; SINGLE NUCLEUS METHYLCYTOSINE SEQUENCING; SPECIES CONSERVATION; SYNAPTOGENESIS; TRANSCRIPTION INITIATION SITE; YOUNG ADULT; ANIMAL; C57BL MOUSE; CELL NUCLEUS; CHEMISTRY; CONSERVED SEQUENCE; CYTOLOGY; DNA SEQUENCE; FRONTAL LOBE; GENETIC EPIGENESIS; MALE; METABOLISM; NERVE CELL; NUCLEOTIDE SEQUENCE; REGULATORY SEQUENCE;

MAMMALIA;

5-METHYLCYTOSINE; ADULT; ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CONSERVED SEQUENCE; CYTOSINE; DNA METHYLATION; EPIGENESIS, GENETIC; FRONTAL LOBE; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEURONS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; SINGLE-CELL ANALYSIS;

EID: 85027126307     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan3351     Document Type: Article

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