American thoracic society/national heart, lung, and blood institute asthma-chronic obstructive pulmonary disease overlap workshop report

American Journal of Respiratory and Critical Care Medicine

Volumn 196, Issue 3, 2017, Pages 375-381

  Woodruff, Prescott G ^a   Van Den Berge, Maarten ^b   Boucher, Richard C ^c   Brightling, Christopher ^d   Burchard, Esteban G ^a   Christenson, Stephanie A ^a   Han, Meilan K ^e   Holtzman, Michael J ^f   Kraft, Monica ^g   Lynch, David A ^h   Martinez, Fernando D ⁱ   Reddel, Helen K ^j   Sin, Don D ^k   Washko, George R ^l   Wenzel, Sally E ^m   Punturieri, Antonello ⁿ   Freemer, Michelle M ⁿ   Wise, Robert A ^o  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Institute for Lung Health   (United Kingdom)

^e UNIVERSITY OF MICHIGAN   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^h DEPARTMENT OF MEDICINE   (United States)

ⁱ UNIVERSITY OF ARIZONA   (United States)

^j UNIVERSITY OF SYDNEY   (Australia)

^k UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^l HARVARD MEDICAL SCHOOL   (United States)

^m UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁿ DLD/NHLBI   (United States)

^o JOHNS HOPKINS UNIVERSITY   (United States)

more..

Author keywords

Asthma; Chronic obstructive pulmonary disease; Overlap

Indexed keywords

BIOLOGICAL MARKER;

ASTHMA; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CONFERENCE PAPER; COUGHING; DISEASE COURSE; DYSPNEA; HUMAN; INFANCY; MUCOCILIARY CLEARANCE; PRIORITY JOURNAL; WHEEZING; CONSENSUS DEVELOPMENT; DIAGNOSTIC IMAGING; LUNG; MEDICAL SOCIETY; NATIONAL HEALTH ORGANIZATION; PATHOPHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; UNITED STATES;

ASTHMA; DIAGNOSTIC IMAGING; LUNG; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SOCIETIES, MEDICAL; UNITED STATES;

EID: 85026795501     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201705-0973WS     Document Type: Conference Paper

References (63)

1. Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it?. Thorax 2009;64:728-735.
2. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-1200.
3. Contoli M, Baraldo S, Marku B, Casolari P, Marwick JA, Turato G, Romagnoli M, Caramori G, Saetta M, Fabbri LM, et al. Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up. J Allergy Clin Immunol 2010;125:830-837.
4. Fabbri LM, Romagnoli M, Corbetta L, Casoni G, Busljetic K, Turato G, Ligabue G, Ciaccia A, Saetta M, Papi A. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:418-424.
5. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, Decramer M; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008;359:1543-1554.
6. van den Berge M, Vonk JM, Gosman M, Lapperre TS, Snoeck-Stroband JB, Sterk PJ, Kunz LI, Hiemstra PS, Timens W, Ten Hacken NH, et al. Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J 2012;40:1098-1105.
7. Bleecker ER, Emmett A, Crater G, Knobil K, Kalberg C. Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: Response by betaagonist reversibility. Pulm Pharmacol Ther 2008;21:682-688.
8. Kitaguchi Y, Fujimoto K, Kubo K, Honda T. Characteristics of COPD phenotypes classified according to the findings of HRCT. Respir Med 2006;100:1742-1752.
9. Postma DS, Kerstjens HA. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158:S187-S192.
10. Tkacova R, Dai DL, Vonk JM, Leung JM, Hiemstra PS, van den Berge M, Kunz L, Hollander Z, Tashkin D, Wise R, et al. Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?. J Allergy Clin Immunol 2016;138:1571-1579.e10.
11. de Marco R, Pesce G, Marcon A, Accordini S, Antonicelli L, Bugiani M, Casali L, Ferrari M, Nicolini G, Panico MG, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): Prevalence and risk factors in young, middle-aged and elderly people from the general population. Plos One 2013;8:e62985.
12. Kauppi P, Kupiainen H, Lindqvist A, Tammilehto L, Kilpeläinen M, Kinnula VL, Haahtela T, Laitinen T. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma 2011;48:279-285.
13. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP; COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respir Res 2011;12:127.
14. Reddel HK. Treatment of overlapping asthma-chronic obstructive pulmonary disease: Can guidelines contribute in an evidence-free zone?. J Allergy Clin Immunol 2015;136:546-552.
15. Global Initiative for Asthma. Diagnosis of asthma, COPD and asthma-COPD overlap syndrome (ACOS). 2015 [accessed 2017 Jun 29]. Available from: Http://goldcopd.org/asthma-copd-asthma-copdoverlap-syndrome/
16. Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, Calhoun WJ, Erzurum S, Gaston B, Israel E, et al. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol 2014;133:1280-1288.
17. Fingleton J, Travers J, Williams M, Charles T, Bowles D, Strik R, Shirtcliffe P, Weatherall M, Beasley R; New Zealand Respiratory Health Survey Study Group. Treatment responsiveness of phenotypes of symptomatic airways obstruction in adults. J Allergy Clin Immunol 2015;136:601-609.
18. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, et al.; National Heart, Lung, Blood Institute's Severe Asthma Research Program. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007;119:405-413.
19. Wang JS, Cherng JM, Perng DS, Lee HS, Wang S. High-resolution computed tomography in assessment of patients with emphysema. Respir Care 2013;58:614-622.
20. Wagner EM, Liu MC, Weinmann GG, Permutt S, Bleecker ER. Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis 1990;141:584-588.
21. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004;364:709-721.
22. Hasegawa M, Nasuhara Y, Onodera Y, Makita H, Nagai K, Fuke S, Ito Y, Betsuyaku T, Nishimura M. Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;173:1309-1315.
23. Washko GR, Diaz AA, Kim V, Barr RG, Dransfield MT, Schroeder J, Reilly JJ, Ramsdell JW, McKenzie A, Van Beek EJ, et al. Computed tomographic measures of airway morphology in smokers and never-smoking normals. J Appl Physiol (1985) 2014;116:668-673.
24. Milne S, King GG. Advanced imaging in COPD: Insights into pulmonary pathophysiology. J Thorac Dis 2014;6:1570-1585.
25. Jain N, Covar RA, Gleason MC, Newell JD Jr, Gelfand EW, Spahn JD. Quantitative computed tomography detects peripheral airway disease in asthmatic children. Pediatr Pulmonol 2005;40:211-218.
26. Matsuoka S, Kurihara Y, Yagihashi K, Hoshino M, Watanabe N, Nakajima Y. Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT. AJR Am J Roentgenol 2008;190:762-769.
27. Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, et al. Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med 2012; 18:1711-1715.
28. Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, et al.; COPDGene Investigators. Association between functional small airway disease and fev1 decline in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016;194:178-184.
29. Donohue KM, Hoffman EA, Baumhauer H, Guo J, Ahmed FS, Lovasi GS, Jacobs DR Jr, Enright P, Barr RG. Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study. J Allergy Clin Immunol 2013;131: 361-368.e1-11.
30. Choi S, Hoffman EA, Wenzel SE, Castro M, Fain S, Jarjour N, Schiebler ML, Chen K, Lin CL; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Quantitative computed tomography imaging-based clustering differentiates asthmatic subgroups with distinctive clinical phenotypes. J Allergy Clin Immunol [online ahead of print] 29 Jan 2017; DOI: 10.1016/j. jaci.2016.11.053.
31. Gibson PG, McDonald VM. Asthma-COPD overlap 2015: now we are six. Thorax 2015;70:683-691.
32. Strunk RC, Weiss ST, Yates KP, Tonascia J, Zeiger RS, Szefler SJ; CAMP Research Group. Mild to moderate asthma affects lung growth in children and adolescents. J Allergy Clin Immunol 2006; 118:1040-1047.
33. James AL, Palmer LJ, Kicic E, Maxwell PS, Lagan SE, Ryan GF, Musk AW. Decline in lung function in the Busselton Health Study: The effects of asthma and cigarette smoking. Am J Respir Crit Care Med 2005;171:109-114.
34. Tagiyeva N, Devereux G, Fielding S, Turner S, Douglas G. Outcomes of childhood asthma and wheezy bronchitis: A 50-year cohort study. Am J Respir Crit Care Med 2016;193:23-30.
35. Perret JL, Dharmage SC, Matheson MC, Johns DP, Gurrin LC, Burgess JA, Marrone J, Markos J, Morrison S, Feather I, et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age. Am J Respir Crit Care Med 2013; 187:42-48.
36. Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: A longitudinal birthcohort study. Lancet 2008;372:1058-1064.
37. Voraphani N, Stern DA, Wright AL, Guerra S, Morgan WJ, Martinez FD. Risk of current asthma among adult smokers with respiratory syncytial virus illnesses in early life. Am J Respir Crit Care Med 2014; 190:392-398.
38. Piedimonte G. Respiratory syncytial virus and asthma: Speed-dating or long-term relationship?. Curr Opin Pediatr 2013;25:344-349.
39. Sikkel MB, Quint JK, Mallia P, Wedzicha JA, Johnston SL. Respiratory syncytial virus persistence in chronic obstructive pulmonary disease. Pediatr Infect Dis J 2008;27:S63-S70.
40. Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat Rev Immunol 2014;14:686-698.
41. Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, et al. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest 2013;123:3967-3982.
42. Jackson DJ, Makrinioti H, Rana BM, Shamji BW, Trujillo-Torralbo MB, Footitt J, Jerico Del-Rosario, Telcian AG, Nikonova A, Zhu J, et al. IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med 2014;190: 1373-1382.
43. Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med 2015;212:681-697.
44. Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, RoswitWT, Miller CA, Heier RF, Byers DE, Brett TJ, et al. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J Clin Invest 2012;122: 4555-4568.
45. Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 2012;337: 937-941.
46. KirkhamS, KolsumU, RousseauK, SinghD, Vestbo J, ThorntonDJ. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:1033-1039.
47. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180: 388-395.
48. Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 2010;125:1028-1036.e13.
49. Barker BL, Brightling CE. Phenotyping the heterogeneity of chronic obstructive pulmonary disease. Clin Sci (Lond) 2013;124:371-387.
50. Ghebre MA, Bafadhel M, Desai D, Cohen SE, Newbold P, Rapley L, Woods J, Rugman P, Pavord ID, Newby C, et al. Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2015;135:63-72.
51. Brightling CE, McKenna S, Hargadon B, Birring S, Green R, Siva R, Berry M, Parker D, Monteiro W, Pavord ID, et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax 2005;60:193-198.
52. Brightling CE, Monteiro W, Ward R, Parker D, Morgan MD, Wardlaw AJ, Pavord ID. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: A randomised controlled trial. Lancet 2000;356:1480-1485.
53. Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, et al.; MENSA Investigators. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014;371:1198-1207.
54. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial. Lancet 2002;360:1715-1721.
55. Siva R, Green RH, Brightling CE, Shelley M, Hargadon B, McKenna S, Monteiro W, Berry M, Parker D, Wardlaw AJ, et al. Eosinophilic airway inflammation and exacerbations of COPD: A randomised controlled trial. Eur Respir J 2007;29:906-913.
56. Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, Verleden G, Demedts IK, Verhamme K, Delporte A, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): A multicentre randomised double-blind placebocontrolled trial. Thorax 2013;68:322-329.
57. Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: Association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 2003;111:1345-1352.
58. Cowan DC, Cowan JO, Palmay R, Williamson A, Taylor DR. Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 2010;65:384-390.
59. Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest 2012;142:86-93.
60. Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O'Byrne PM, Stryszak P, Gann L, Sadeh J, Chanez P; Study Investigators. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: A randomized, placebo-controlled clinical trial. Clin Exp Allergy 2012;42:1097-1103.
61. Faner R, Cruz T, Casserras T, López-Giraldo A, Noell G, Coca I, Tal-Singer R, Miller B, Rodriguez-Roisin R, Spira A, et al. Network analysis of lung transcriptomics reveals a distinct b-cell signature in emphysema. Am J Respir Crit Care Med 2016;193:1242-1253.
62. Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap; clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2015;191:758-766.
63. Pino-Yanes M, Thakur N, Gignoux CR, Galanter JM, Roth LA, Eng C, Nishimura KK, Oh SS, Vora H, Huntsman S, et al. Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 2015;135:228-235.