Risk factors for trauma-induced coagulopathy- and transfusion-associated multiple organ failure in severely injured trauma patients

Frontiers in Medicine

Volumn 2, Issue APR, 2015, Pages

  Balvers, Kirsten ^a   Wirtz, Mathijs R ^a   van Dieren, Susan ^a   Goslings, J Carel ^a   Juffermans, Nicole P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Coagulopathy; Multiple organ failure; Resuscitation; Transfusion; Trauma

Indexed keywords

EID: 85026443000     PISSN: None     EISSN: 2296858X     Source Type: Journal    
DOI: 10.3389/fmed.2015.00024     Document Type: Article

References (83)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma (1995) 38(2):185-93. doi: 10.1097/00005373-199502000-00006
2. Soreide K, Kruger AJ, Vardal AL, Ellingsen CL, Soreide E, Lossius HM. Epidemiology and contemporary patterns of trauma deaths: changing place, similar pace, older face. World J Surg (2007) 31(11):2092-103. doi:10.1007/s00268-007-9226-9
3. Dewar DC, Tarrant SM, King KL, Balogh ZJ. Changes in the epidemiology and prediction of multiple-organ failure after injury. J Trauma Acute Care Surg (2013) 74(3):774-9. doi:10.1097/TA.0b013e31827a6e69
4. Nast-Kolb D, Aufmkolk M, Rucholtz S, Obertacke U, Waydhas C. Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma. J Trauma (2001) 51(5):835-41. doi:10.1097/00005373-200111000-00003
5. Brattstrom O, Granath F, Rossi P, Oldner A. Early predictors of morbidity and mortality in trauma patients treated in the intensive care unit. Acta Anaesthesiol Scand (2010) 54(8):1007-17. doi:10.1111/j.1399-6576.2010.02266.x
6. Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A. A 12-year prospective study of postinjury multiple organ failure: has anything changed? Arch Surg (2005) 140(5):432-8. doi:10.1001/archsurg.140.5.432
7. Dunn EL, Moore EE, Breslich DJ, Galloway WB. Acidosis-induced coagulopathy. Surg Forum (1979) 30:471-3
8. Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma (2009) 67(1):125-31. doi:10.1097/TA.0b013e31818b2483
9. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg (2011) 254(2):194-200. doi:10.1097/SLA.0b013e318226113d
10. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma (2003) 55(1):39-44. doi:10.1097/01.TA.0000075338.21177.EF
11. Hess JR, Lindell AL, Stansbury LG, Dutton RP, Scalea TM. The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. Transfusion (2009) 49(1):34-9. doi:10.1111/j.1537-2995.2008.01944.x
12. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma (2003) 54(6):1127-30. doi:10.1097/01.TA.0000069184.82147.06
13. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma (2008) 64(2 Suppl):S64-8. doi:10.1097/TA.0b013e318160772d
14. del Junco DJ, Holcomb JB, Fox EE, Brasel KJ, Phelan HA, Bulger EM, et al. Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study. J Trauma Acute Care Surg (2013) 75(1 Suppl 1):S24-30. doi:10.1097/TA.0b013e31828fa3b9
15. Brown LM, Aro SO, Cohen MJ, Holcomb JB, Wade CE, Brasel KJ, et al. A high fresh frozen plasma: packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio. J Trauma (2011) 71(2 Suppl 3):S358-63. doi:10.1097/TA.0b013e318227f152
16. Morrison CA, Carrick MM, Norman MA, Scott BG, Welsh FJ, Tsai P, et al. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial. J Trauma (2011) 70(3):652-63. doi:10.1097/TA.0b013e31820e77ea
17. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (2009) 339:b2535. doi:10.1136/bmj.b2535
18. Sauaia A, Moore EE, Johnson JL, Ciesla DJ, Biffl WL, Banerjee A. Validation of postinjury multiple organ failure scores. Shock (2009) 31(5):438-47. doi:10.1097/SHK.0b013e31818ba4c6
19. Grotz M, von GM, Stalp M, Kaufmann U, Hildebrand F, Pape HC. [Scoring multiple organ failure after severe trauma. Comparison of the Goris, Marshall and Moore scores]. Chirurg (2001) 72(6):723-30. doi:10.1007/s001040170130
20. Antonelli M, Moreno R, Vincent JL, Sprung CL, Mendoca A, Passariello M, et al. Application of SOFA score to trauma patients. Sequential organ failure assessment. Intensive Care Med (1999) 25(4):389-94. doi:10.1007/s001340050863
21. Wells G, Shea B, O'Connel J. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analysis (2011). Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
22. Higgins JPT, Altman DG. Chapter 8: assessing risk of bias in included studies. In: Higgins J, Green S, editors. The Cochrane Collaboration, 5.0.1 ed. Chichester: John Wiley & Sons, Ltd (2008)
23. Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ. Posttraumatic complications and inflammatory mediators. Arch Surg (1986) 121(8):886-90. doi:10.1001/archsurg.1986.01400080028004
24. Wudel JH, Morris JA Jr, Yates K, Wilson A, Bass SM. Massive transfusion: outcome in blunt trauma patients. J Trauma (1991) 31(1):1-7. doi:10.1097/00005373-199101000-00001
25. Sigurdsson GH, Christenson JT, El-Rakshy MB, Sadek S. Intestinal platelet trapping after traumatic and septic shock. An early sign of sepsis and multiorgan failure in critically ill patients? Crit Care Med (1992) 20:458-67. doi:10.1097/00003246-199204000-00005
26. Waydhas C, Nast-Kolb D, Kick M, Zettl R, Wiesholler J, Trupka A, et al. [Operation planning of secondary interventions after polytrauma]. Unfallchirurg (1994) 97(5):244-9
27. Gando S, Nakanishi Y, Tedo I. Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome. Crit Care Med (1995) 23(11):1835-42. doi:10.1097/00003246-199511000-00009
28. Gando S, Nakanishi Y, Kameue T, Nanzaki S. Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase. J Trauma (1995) 39(4):660-4. doi:10.1097/00005373-199510000-00007
29. Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF. Multiple organ failure can be predicted as early as 12 hours after injury. J Trauma (1998) 45(2):291-301. doi:10.1097/00005373-199808000-00014
30. Gando S, Nanzaki S, Kemmotsu O. Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis. Ann Surg (1999) 229(1):121-7. doi:10.1097/00000658-199901000-00016
31. Raeburn CD, Moore EE, Biffl WL, Johnson JL, Meldrum DR, Offner PJ, et al. The abdominal compartment syndrome is a morbid complication of postinjury damage control surgery. Am J Surg (2001) 182:542-6. doi:10.1016/S0002-9610(01)00821-2
32. Newell MA, Bard MR, Goettler CE, Toschlog EA, Schenarts PJ, Sagraves SG, et al. Body mass index and outcomes in critically injured blunt trauma patients: weighing the impact. J Am Coll Surg (2007) 204(5):1056-61. doi:10.1016/j.jamcollsurg.2006.12.042
33. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al. Early coagulopathy in multiple injury: an analysis from the German trauma registry on 8724 patients. Injury (2007) 38(3):298-304. doi:10.1016/j.injury.2006.10.003
34. Paffrath T, Wafaisade A, Lefering R, Simanski C, Bouillon B, Spanholtz T, et al. Venous thromboembolism after severe trauma: incidence, risk factors and outcome. Injury (2010) 41(1):97-101. doi:10.1016/j.injury.2009.06.010
35. Nydam TL, Kashuk JL, Moore EE, Johnson JL, Burlew CC, Biffl WL, et al. Refractory postinjury thrombocytopenia is associated with multiple organ failure and adverse outcomes. J Trauma (2011) 70(2):401-6. doi:10.1097/TA.0b013e31820b5c85
36. Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, et al. Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 73(6):1395-400. doi:10.1097/TA.0b013e31825b9f05
37. Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ. Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C. J Trauma Acute Care Surg (2012) 73(6):1389-94. doi:10.1097/TA.0b013e318270d595
38. Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg (2012) 255(2):379-85. doi:10.1097/SLA.0b013e318235d9e6
39. Cole E, Davenport R, De'Ath H, Manson J, Brockamp T, Brohi K. Coagulation system changes associated with susceptibility to infection in trauma patients. J Trauma Acute Care Surg (2013) 74(1):51-7. doi:10.1097/TA.0b013e3182788b0f
40. Trentzsch H, Nienaber U, Behnke M, Lefering R, Piltz S. Female sex protects from organ failure and sepsis after major trauma haemorrhage. Injury (2014) 45(Suppl 3):S20-8. doi:10.1016/j.injury.2014.08.013
41. Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC. Early predictors of postinjury multiple organ failure. Arch Surg (1994) 129(1):39-45. doi:10.1001/archsurg.1994.01420250051006
42. Lehmann U, Grotz M, Regel G, Rudolph S, Tscherne H. [Does initial management of polytrauma patients have an effect on the development of multiple organ failure? Evaluation of preclinical and clinical data of 1,112 polytrauma patients]. Unfallchirurg (1995) 98(8):442-6
43. Moore FA, Moore EE, Sauaia A. Blood transfusion. An independent risk factor for postinjury multiple organ failure. Arch Surg (1997) 132(6):620-4. doi:10.1001/archsurg.1997.01430300062013
44. Waydhas C, Nast-Kolb D, Gippner-Steppert C, Trupka A, Pfundstein C, Schweiberer L, et al. High-dose antithrombin III treatment of severely injured patients: results of a prospective study. J Trauma (1998) 45(5):931-40. doi:10.1097/00005373-199811000-00015
45. Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, et al. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg (1999) 178(6):570-2. doi:10.1016/S0002-9610(99)00239-1
46. Cryer HG, Leong K, McArthur DL, Demetriades D, Bongard FS, Fleming AW, et al. Multiple organ failure: by the time you predict it, it's already there. J Trauma (1999) 46(4):597-604. doi:10.1097/00005373-199904000-00007
47. Frink M, Pape HC, van Griensven M, Krettek C, Chaudry IH, Hildebrand F. Influence of sex and age on mods and cytokines after multiple injuries. Shock (2007) 27:151-6. doi:10.1097/01.shk.0000239767.64786
48. Bulger EM, Cuschieri J, Warner K, Maier RV. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg (2007) 245(4):635-41. doi:10.1097/01.sla.0000251367.44890.ae
49. Sperry JL, Nathens AB, Frankel HL, Vanek SL, Moore EE, Maier RV, et al. Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med (2008) 36(6):1838-45. doi:10.1097/CCM.0b013e3181760c14
50. Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, et al. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma (2008) 65(5):986-93. doi:10.1097/TA.0b013e3181878028
51. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the trauma registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang (2008) 95(2):112-9. doi:10.1111/j.1423-0410.2008.01074.x
52. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg (2008) 248(3):447-58. doi:10.1097/SLA.0b013e318185a9ad
53. Jastrow KM III, Gonzalez EA, McGuire MF, Suliburk JW, Kozar RA, Iyengar S, et al. Early cytokine production risk stratifies trauma patients for multiple organ failure. J Am Coll Surg (2009) 209(3):320-31. doi:10.1016/j.jamcollsurg.2009.05.002
54. Englehart MS, Cho SD, Morris MS, Gee AC, Riha G, Underwood SJ, et al. Use of leukoreduced blood does not reduce infection, organ failure, or mortality following trauma. World J Surg (2009) 33(8):1626-32. doi:10.1007/s00268-009-0076-5
55. Dewar DC, Mackay P, Balogh Z. Epidemiology of post-injury multiple organ failure in an Australian trauma system. ANZ J Surg (2009) 79(6):431-6. doi:10.1111/j.1445-2197.2009.04968.x
56. Mahambrey TD, Fowler RA, Pinto R, Smith TS, Callum JL, Pisani NS, et al. Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort study. Can J Anaesth (2009) 56(10):740-50. doi:10.1007/s12630-009-9151-5
57. Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, et al. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma (2009) 67(2):221-7. doi:10.1097/TA.0b013e3181ad5957
58. Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, et al. The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. Transfusion (2009) 49(Suppl 5):240S-7S. doi:10.1111/j.1537-2995.2008.01987.x
59. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma (2009) 66(1):41-8; discussion 48-9. doi:10.1097/TA.0b013e31819313bb
60. Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, et al. Results of the CONTROL trial: efficacy and safety of recombinant activated factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 69(3):489-500. doi:10.1097/TA.0b013e3181edf36e
61. Johnson JL, Moore EE, Kashuk JL, Banerjee A, Cothren CC, Biffl WL, et al. Effect of blood products transfusion on the development of postinjury multiple organ failure. Arch Surg (2010) 145(10):973-7. doi:10.1001/archsurg.2010.216
62. Nienaber U, Innerhofer P, Westermann I, Schochl H, Attal R, Breitkopf R, et al. The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury (2011) 42(7):697-701. doi:10.1016/j.injury.2010.12.015
63. Perkins JG, Cap AP, Spinella PC, Shorr AF, Beekley AC, Grathwohl KW, et al. Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME). Transfusion (2011) 51(2):242-52. doi:10.1111/j.1537-2995.2010.02818.x
64. Wafaisade A, Maegele M, Lefering R, Braun M, Peiniger S, Neugebauer E, et al. High plasma to red blood cell ratios are associated with lower mortality rates in patients receiving multiple transfusion (4 =red blood cell units >10) during acute trauma resuscitation. J Trauma (2011) 70(1):81-8; discussion 88-9. doi:10.1097/TA.0b013e3182032e0b
65. Hussmann B, Taeger G, Lefering R, Waydhas C, Nast-Kolb D, Ruchholtz S, et al. [Lethality and outcome in multiple injured patients after severe abdominal and pelvic trauma. Influence of preclinical volume replacement-an analysis of 604 patients from the trauma registry of the DGU]. Unfallchirurg (2011) 114(8):705-12. doi:10.1007/s00113-010-1842-4
66. Brakenridge SC, Phelan HA, Henley SS, Golden RM, Kashner TM, Eastman AE, et al. Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury. J Trauma (2011) 71(2):299-305. doi:10.1097/TA.0b013e318224d328
67. Borgman MA, Spinella PC, Holcomb JB, Blackbourne LH, Wade CE, Lefering R, et al. The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang (2011) 101(1):44-54. doi:10.1111/j.1423-0410.2011.01466.x
68. Innerhofer P, Westermann I, Tauber H, Breitkopf R, Fries D, Kastenberger T, et al. The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. Injury (2013) 44:209-16. doi:10.1016/j.injury.2012.08.047
69. Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, et al. The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 40(4):1129-35. doi:10.1097/CCM.0b013e3182376e9f
70. Neal MD, Hoffman MK, Cuschieri J, Minei JP, Maier RV, Harbrecht BG, et al. Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way. J Trauma Acute Care Surg (2012) 72(4):892-8. doi:10.1097/TA.0b013e31823d84a7
71. Duchesne JC, Simms E, Guidry C, Duke M, Beeson E, McSwain NE, et al. Damage control immunoregulation: is there a role for low-volume hypertonic saline resuscitation in patients managed with damage control surgery? Am Surg (2012) 78(9):962-8
72. Pape HC, van GM, Rice J, Gansslen A, Hildebrand F, Zech S, et al. Major secondary surgery in blunt trauma patients and perioperative cytokine liberation: determination of the clinical relevance of biochemical markers. J Trauma (2001) 50(6):989-1000. doi:10.1097/00005373-200106000-00004
73. Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost (2010) 8(9):1919-25. doi:10.1111/j.1538-7836.2010.03945.x
74. Floccard B, Rugeri L, Faure A, Saint DM, Boyle EM, Peguet O, et al. Early coagulopathy in trauma patients: an on-scene and hospital admission study. Injury (2012) 43(1):26-32. doi:10.1016/j.injury.2010.11.003
75. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost (2013) 11(2):307-14. doi:10.1111/jth.12078
76. Nielsen VG. A comparison of the thrombelastograph and the ROTEM. Blood Coagul Fibrinolysis (2007) 18(3):247-52. doi:10.1097/MBC.0b013e328092ee05
77. Innerhofer P, Westermann I, Tauber H, Breitkopf R, Fries D, Kastenberger T, et al. The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. Injury (2013) 44(2):209-16. doi:10.1016/j.injury.2012.08.047
78. Tomori T, Hupalo D, Teranishi K, Michaud S, Hammett M, Freilich D, et al. Evaluation of coagulation stages of hemorrhaged swine: comparison of thromboelastography and rotational elastometry. Blood Coagul Fibrinolysis (2010) 21(1):20-7. doi:10.1097/MBC.0b013e32833113e9
79. Zehtabchi S, Nishijima DK. Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe trauma. Acad Emerg Med (2009) 16(5):371-8. doi:10.1111/j.1553-2712.2009.00386.x
80. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA (2015) 313(5):471-82. doi:10.1001/jama.2015.12
81. Lo CK, Mertz D, Loeb M. Newcastle-Ottawa scale: comparing reviewers' to authors' assessments. BMC Med Res Methodol (2014) 14:45. doi:10.1186/1471-2288-14-45
82. Hartling L, Milne A, Hamm MP, Vandermeer B, Ansari M, Tsertsvadze A, et al. Testing the Newcastle Ottawa scale showed low reliability between individual reviewers. J Clin Epidemiol (2013) 66(9):982-93. doi:10.1016/j.jclinepi.2013.03.003
83. Higgins JPT, Green S. (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011]. The Cochrane Collaboration (2011). Available from: http://www.cochrane-handbook.org