The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial

Journal of Nutrition and Intermediary Metabolism

Volumn 9, Issue , 2017, Pages 6-11

  Milajerdi, Alireza ^a   Jazayeri, Shima ^b   Bitarafan, Vida ^a   Hashemzadeh, Najmeh ^c   Shirzadi, Elham ^c   Derakhshan, Zhaleh ^c   Mahmoodi, Mahmood ^d   Rayati, Alireza ^e   Djazayeri, Abolghassem ^a   Akhondzadeh, Shahin ^f  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e PAYAME NOOR UNIVERSITY   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocus sativus L.; Liver enzymes; Liver function; Renal function; Saffron; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; CROCUS SATIVUS EXTRACT; PLACEBO; URIC ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANTHROPOMETRY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROCUS SATIVUS; DIABETIC PATIENT; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MICROCAPSULE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL;

EID: 85026439529     PISSN: None     EISSN: 23523859     Source Type: Journal    
DOI: 10.1016/j.jnim.2017.07.002     Document Type: Article

References (28)

1. Go, A.S., Mozaffarian, D., Roger, V.L., Benjamin, E.J., Berry, J.D., Blaha, M.J., et al. Heart disease and stroke statistics-2014 update. Circulation, 129(3), 2014.
2. Poirier, P., Giles, T.D., Bray, G.A., Hong, Y., Stern, J.S., Pi-Sunyer, F.X., et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss an update of the 1997 American Heart Association Scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation 113:6 (2006), 898–918.
3. Jafarnejad, S., Saremi, S., Jafarnejad, F., Arab, A., Effects of a multispecies probiotic mixture on glycemic control and inflammatory status in women with gestational diabetes: a randomized controlled clinical trial. J Nutr Metab, 2016, 2016 5190846.
4. Horwich, T.B., Fonarow, G.C., Hamilton, M.A., MacLellan, W.R., Woo, M.A., Tillisch, J.H., The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol 38:3 (2001), 789–795.
5. Lavie, C.J., Osman, A.F., Milani, R.V., Mehra, M.R., Body composition and prognosis in chronic systolic heart failure: the obesity paradox. Am J Cardiol 91:7 (2003), 891–894.
6. Vicariotto, F., Mogna, L., Del Piano, M., Effectiveness of the two microorganisms Lactobacillus fermentum LF15 and Lactobacillus plantarum LP01, formulated in slow-release vaginal tablets, in women affected by bacterial vaginosis: a pilot study. J Clin Gastroenterol 48:1 (2014), 106–112.
7. Jiang, X.R., Awati, A., Agazzi, A., Vitari, F., Ferrari, A., Bento, H., et al. Effects of a blend of essential oils and an enzyme combination on nutrient digestibility, ileum histology and expression of inflammatory mediators in weaned piglets. Animal 9:3 (2015), 417–426.
8. Szatraj, K., Szczepankowska, A.K., Saczynska, V., Florys, K., Gromadzka, B., Lepek, K., et al. Expression of avian influenza haemagglutinin (H5) and chicken interleukin 2 (chIL-2) under control of the ptcB promoter in Lactococcus lactis. Acta Biochim Pol 61:3 (2014), 609–614.
9. Nabatanzi, R., Bayigga, L., Ssinabulya, I., Kiragga, A., Kambugu, A., Olobo, J., et al. Low antigen-specific CD4 T-cell immune responses despite normal absolute CD4 counts after long-term antiretroviral therapy an African cohort. Immunol Lett 162:2 (2014), 264–272.
10. Hunking, P., Lifestyle advice in preventing and treating type 2 diabetes. J Fam Health 16:4 (2005), 109–112.
11. Inoue, Y., Kambara, T., Murata, N., Komori-Yamaguchi, J., Matsukura, S., Takahashi, Y., et al. Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum cytokines of atopic dermatitis in Japanese adults: a double-blind, randomized, clinical trial. Int Arch Allergy Immunol 165:4 (2014), 247–254.
12. Vitaglione, P., Mennella, I., Ferracane, R., Rivellese, A.A., Giacco, R., Ercolini, D., et al. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Am J Clin Nutr 101:2 (2015), 251–261.
13. Abdullaev, F., Espinosa-Aguirre, J., Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 28:6 (2004), 426–432.
14. Akhondzadeh, S., Sabet, M.S., Harirchian, M., Togha, M., Cheraghmakani, H., Razeghi, S., et al. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther 35:5 (2010), 581–588.
15. Xing, Y., Wang, S., Fan, J., Oso, A.O., Kim, S.W., Xiao, D., et al. Effects of dietary supplementation with lysine-yielding Bacillus subtilis on gut morphology, cecal microflora, and intestinal immune response of Linwu ducks. J Anim Sci 93:7 (2015), 3449–3457.
16. Sepideh, A., Karim, P., Hossein, A., Leila, R., Hamdollah, M., Mohammad, E.G., et al. Effects of multistrain probiotic supplementation on glycemic and inflammatory indices in patients with nonalcoholic fatty liver disease: a double-blind randomized clinical trial. J Am Coll Nutr 2 (2015), 1–6.
17. Pitsikas, N., Boultadakis, A., Georgiadou, G., Tarantilis, P., Sakellaridis, N., Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine 15:12 (2008), 1135–1139.
18. Kwon, H.H., Yoon, J.Y., Park, S.Y., Min, S., Suh, D.H., Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. Dermatology 229:2 (2014), 102–109.
19. Mashmoul, M., Azlan, A., Mohtarrudin, N., Yusof, B.N.M., Khaza'ai, H., Khoo, H.E., et al. Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complement Altern Med, 16(1), 2016, 401.
20. Tajadadi-Ebrahimi, M., Bahmani, F., Shakeri, H., Hadaegh, H., Hijijafari, M., Abedi, F., et al. Effects of daily consumption of synbiotic bread on insulin metabolism and serum high-sensitivity C-reactive protein among diabetic patients: a double-blind, randomized, controlled clinical trial. Ann Nutr Metab 65:1 (2014), 34–41.
21. Huang, H.Y., Chen, Y.C., Wang, P.C., Tsai, M.A., Yeh, S.C., Liang, H.J., et al. Efficacy of a formalin-inactivated vaccine against Streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization. Vaccine 32:51 (2014), 7014–7020.
22. Harslof, L.B., Damsgaard, C.T., Andersen, A.D., Aakjaer, D.L., Michaelsen, K.F., Hellgren, L.I., et al. Reduced ex vivo stimulated IL-6 response in infants randomized to fish oil from 9 to 18 months, especially among PPARG2 and COX2 wild types. Prostagl Leukot Essent Fat Acids 94 (2015), 21–27.
23. Villar-Garcia, J., Hernandez, J.J., Guerri-Fernandez, R., Gonzalez, A., Lerma, E., Guelar, A., et al. Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients: a double-blind, randomized, placebo-controlled trial. J Acquir Immune Defic Syndr 68:3 (2015), 256–263.
24. Yang, O.O., Kelesidis, T., Cordova, R., Khanlou, H., Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial. AIDS Res Hum Retroviruses 30:10 (2014), 988–995.
25. Jensen, G.S., Carter, S.G., Reeves, S.G., Robinson, L.E., Benson, K.F., Anti-inflammatory properties of a dried fermentate in vitro and in vivo. J Med food 18:3 (2015), 378–384.
26. Loizzo, M.R., Marrelli, M., Pugliese, A., Conforti, F., Nadjafi, F., Menichini, F., et al. Crocus cancellatus subsp. damascenus stigmas: chemical profile, and inhibition of α-amylase, α-glucosidase and lipase, key enzymes related to type 2 diabetes and obesity. J Enzyme Inhib Med Chem 31:2 (2016), 212–218.
27. Milajerdi, A., Bitarafan, V., Mahmoudi, M., A review on the effects of saffron extract and its constituents on factors related to neurologic, cardiovascular and gastrointestinal diseases. J Med Plants 3:55 (2015), 9–28.
28. Milajerdi, A., Djafarian, K., Hosseini, B., The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. J Nutr Intermed Metab 3 (2016), 23–32.