메뉴 건너뛰기




Volumn 20, Issue 2, 2018, Pages 238-244

Prevention of cardiovascular disease through reduction of glycaemic exposure in type 2 diabetes: A perspective on glucose-lowering interventions

Author keywords

antidiabetic drug; cardiovascular disease; clinical trial; glycaemic control; randomised trial; systematic review

Indexed keywords

ANTIDIABETIC AGENT; HEMOGLOBIN A1C; PLACEBO; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

EID: 85026399987     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13033     Document Type: Review
Times cited : (54)

References (46)
  • 1
    • 34547751904 scopus 로고    scopus 로고
    • Mortality trends in men and women with diabetes, 1971 to 2000
    • Gregg EW, Gu Q, Cheng YJ, Narayan KM, Cowie CC. Mortality trends in men and women with diabetes, 1971 to 2000. Ann Intern Med. 2007;147(3):149–155.
    • (2007) Ann Intern Med , vol.147 , Issue.3 , pp. 149-155
    • Gregg, E.W.1    Gu, Q.2    Cheng, Y.J.3    Narayan, K.M.4    Cowie, C.C.5
  • 2
    • 79952260576 scopus 로고    scopus 로고
    • Diabetes mellitus, fasting glucose, and risk of cause-specific death
    • Seshasai SR, Kaptoge S, Thompson A, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–841.
    • (2011) N Engl J Med , vol.364 , Issue.9 , pp. 829-841
    • Seshasai, S.R.1    Kaptoge, S.2    Thompson, A.3
  • 4
    • 4644351335 scopus 로고    scopus 로고
    • Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
    • Selvin E, Marinopoulos S, Berkenblit G, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med. 2004;141(6):421–431.
    • (2004) Ann Intern Med , vol.141 , Issue.6 , pp. 421-431
    • Selvin, E.1    Marinopoulos, S.2    Berkenblit, G.3
  • 5
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405–412.
    • (2000) BMJ , vol.321 , Issue.7258 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 6
    • 24944482507 scopus 로고    scopus 로고
    • The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
    • Gerstein HC, Pogue J, Mann JF, et al. The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis. Diabetologia. 2005;48(9):1749–1755.
    • (2005) Diabetologia , vol.48 , Issue.9 , pp. 1749-1755
    • Gerstein, H.C.1    Pogue, J.2    Mann, J.F.3
  • 7
    • 0034071036 scopus 로고    scopus 로고
    • Long-term results of the Kumamoto study on optimal diabetes control in type 2 diabetic patients
    • Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto study on optimal diabetes control in type 2 diabetic patients. Diabetes Care. 2000;23(suppl 2):B21–B29.
    • (2000) Diabetes Care , vol.23 , pp. B21-B29
    • Shichiri, M.1    Kishikawa, H.2    Ohkubo, Y.3    Wake, N.4
  • 8
    • 53749091595 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577–1589.
    • (2008) N Engl J Med , vol.359 , Issue.15 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 9
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545–2559.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 10
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358(24):2560–2572.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 11
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • Duckworth W, Abraira C, Moritz T, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–139.
    • (2009) N Engl J Med , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 12
    • 70349881450 scopus 로고    scopus 로고
    • Intensive glucose control and macrovascular outcomes in type 2 diabetes
    • Turnbull FM, Abraira C, Anderson RJ, et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia. 2009;52(11):2288–2298.
    • (2009) Diabetologia , vol.52 , Issue.11 , pp. 2288-2298
    • Turnbull, F.M.1    Abraira, C.2    Anderson, R.J.3
  • 13
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    • Ray KK, Seshasai SR, Wijesuriya S, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet. 2009;373(9677):1765–1772.
    • (2009) Lancet , vol.373 , Issue.9677 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.2    Wijesuriya, S.3
  • 14
    • 74949117631 scopus 로고    scopus 로고
    • The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
    • Bonds DE, Miller ME, Bergenstal RM, et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ. 2010;340:b4909.
    • (2010) BMJ , vol.340 , pp. b4909
    • Bonds, D.E.1    Miller, M.E.2    Bergenstal, R.M.3
  • 15
    • 77957742069 scopus 로고    scopus 로고
    • Severe hypoglycemia and risks of vascular events and death
    • Zoungas S, Patel A, Chalmers J, et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med. 2010;363(15):1410–1418.
    • (2010) N Engl J Med , vol.363 , Issue.15 , pp. 1410-1418
    • Zoungas, S.1    Patel, A.2    Chalmers, J.3
  • 16
    • 84891818467 scopus 로고    scopus 로고
    • Is glucose control important for prevention of cardiovascular disease in diabetes?
    • Mannucci E, Dicembrini I, Lauria A, Pozzilli P. Is glucose control important for prevention of cardiovascular disease in diabetes? Diabetes Care. 2013;36(suppl 2):S259–S263.
    • (2013) Diabetes Care , vol.36 , pp. S259-S263
    • Mannucci, E.1    Dicembrini, I.2    Lauria, A.3    Pozzilli, P.4
  • 17
    • 85065599284 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2017: summary of revisions
    • Standards of medical care in diabetes-2017: summary of revisions. Diabetes Care. 2017;40(suppl 1):S4–S5.
    • (2017) Diabetes Care , vol.40 , pp. S4-S5
  • 18
    • 84928699536 scopus 로고    scopus 로고
    • Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials
    • Udell JA, Cavender MA, Bhatt DL, Chatterjee S, Farkouh ME, Scirica BM. Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: a meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol. 2015;3(5):356–366.
    • (2015) Lancet Diabetes Endocrinol , vol.3 , Issue.5 , pp. 356-366
    • Udell, J.A.1    Cavender, M.A.2    Bhatt, D.L.3    Chatterjee, S.4    Farkouh, M.E.5    Scirica, B.M.6
  • 19
    • 1442324404 scopus 로고    scopus 로고
    • The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study
    • Fox CS, Sullivan L, D'Agostino RB Sr, Wilson PW. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care. 2004;27(3):704–708.
    • (2004) Diabetes Care , vol.27 , Issue.3 , pp. 704-708
    • Fox, C.S.1    Sullivan, L.2    D'Agostino, R.B.3    Wilson, P.W.4
  • 20
    • 0030848518 scopus 로고    scopus 로고
    • Cumulative glycemic exposure and microvascular complications in insulin-dependent diabetes mellitus. The glycemic threshold revisited
    • Orchard TJ, Forrest KY, Ellis D, Becker DJ. Cumulative glycemic exposure and microvascular complications in insulin-dependent diabetes mellitus. The glycemic threshold revisited. Arch Intern Med. 1997;157(16):1851–1856.
    • (1997) Arch Intern Med , vol.157 , Issue.16 , pp. 1851-1856
    • Orchard, T.J.1    Forrest, K.Y.2    Ellis, D.3    Becker, D.J.4
  • 21
    • 84871084322 scopus 로고    scopus 로고
    • Area-under-the-HbA1c-curve above the normal range and the prediction of microvascular outcomes: an analysis of data from the Diabetes Control and Complications Trial
    • Maple-Brown LJ, Ye C, Retnakaran R. Area-under-the-HbA1c-curve above the normal range and the prediction of microvascular outcomes: an analysis of data from the Diabetes Control and Complications Trial. Diabet Med. 2013;30(1):95–99.
    • (2013) Diabet Med , vol.30 , Issue.1 , pp. 95-99
    • Maple-Brown, L.J.1    Ye, C.2    Retnakaran, R.3
  • 22
    • 33845439073 scopus 로고    scopus 로고
    • Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes
    • Dyck PJ, Davies JL, Clark VM, et al. Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes. Diabetes Care. 2006;29(10):2282–2288.
    • (2006) Diabetes Care , vol.29 , Issue.10 , pp. 2282-2288
    • Dyck, P.J.1    Davies, J.L.2    Clark, V.M.3
  • 23
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353(25):2643–2653.
    • (2005) N Engl J Med , vol.353 , Issue.25 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 24
    • 67349251550 scopus 로고    scopus 로고
    • Megatrials in type 2 diabetes. From excitement to frustration?
    • Del Prato S. Megatrials in type 2 diabetes. From excitement to frustration? Diabetologia. 2009;52(7):1219–1226.
    • (2009) Diabetologia , vol.52 , Issue.7 , pp. 1219-1226
    • Del Prato, S.1
  • 25
    • 84983667048 scopus 로고    scopus 로고
    • Randomized trials to evaluate cardiovascular safety of Antihyperglycemic medications: a worthwhile effort?
    • Steg PG, Roussel R. Randomized trials to evaluate cardiovascular safety of Antihyperglycemic medications: a worthwhile effort? Circulation. 2016;134(8):571–573.
    • (2016) Circulation , vol.134 , Issue.8 , pp. 571-573
    • Steg, P.G.1    Roussel, R.2
  • 26
    • 79960245269 scopus 로고    scopus 로고
    • Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial
    • Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T. Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial. Lancet. 2011;378(9786):156–67.
    • (2011) Lancet , vol.378 , Issue.9786 , pp. 156-167
    • Griffin, S.J.1    Borch-Johnsen, K.2    Davies, M.J.3    Khunti, K.4    Rutten, G.E.5    Sandbæk, A.6    Sharp, S.J.7    Simmons, R.K.8    van den Donk, M.9    Wareham, N.J.10    Lauritzen, T.11
  • 27
    • 84969930811 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in treatment of type 2 diabetes mellitus on cardiovascular outcomes: a meta-analysis of data from 58,160 patients in 13 randomized controlled trials
    • Fang HJ, Zhou YH, Tian YJ, Du HY, Sun YX, Zhong LY. Effects of intensive glucose lowering in treatment of type 2 diabetes mellitus on cardiovascular outcomes: a meta-analysis of data from 58,160 patients in 13 randomized controlled trials. Int J Cardiol. 2016;218:50–58.
    • (2016) Int J Cardiol , vol.218 , pp. 50-58
    • Fang, H.J.1    Zhou, Y.H.2    Tian, Y.J.3    Du, H.Y.4    Sun, Y.X.5    Zhong, L.Y.6
  • 28
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–986.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 977-986
  • 29
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 2005;366(9493):1279–1289.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 30
    • 20244384563 scopus 로고    scopus 로고
    • Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity
    • Malmberg K, Ryden L, Wedel H, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J. 2005;26(7):650–661.
    • (2005) Eur Heart J , vol.26 , Issue.7 , pp. 650-661
    • Malmberg, K.1    Ryden, L.2    Wedel, H.3
  • 31
    • 67149142042 scopus 로고    scopus 로고
    • A randomized trial of therapies for type 2 diabetes and coronary artery disease
    • Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360(24):2503–2515.
    • (2009) N Engl J Med , vol.360 , Issue.24 , pp. 2503-2515
    • Frye, R.L.1    August, P.2    Brooks, M.M.3
  • 32
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    • Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet. 2009;373(9681):2125–2135.
    • (2009) Lancet , vol.373 , Issue.9681 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 33
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • Gerstein HC, Bosch J, Dagenais GR, et al. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med. 2012;367(4):319–328.
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3
  • 34
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369(14):1317–1326.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 35
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369(14):1327–1335.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 36
    • 84880323061 scopus 로고    scopus 로고
    • Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
    • Look ARG, Wing RR, Bolin P, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145–154.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 145-154
    • Look, A.R.G.1    Wing, R.R.2    Bolin, P.3
  • 37
    • 84898614282 scopus 로고    scopus 로고
    • Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial
    • Lincoff AM, Tardif JC, Schwartz GG, et al. Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. JAMA. 2014;311(15):1515–1525.
    • (2014) JAMA , vol.311 , Issue.15 , pp. 1515-1525
    • Lincoff, A.M.1    Tardif, J.C.2    Schwartz, G.G.3
  • 38
    • 84937053742 scopus 로고    scopus 로고
    • Effect of Sitagliptin on cardiovascular outcomes in type 2 diabetes
    • Green JB, Bethel MA, Armstrong PW, et al. Effect of Sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373(3):232–242.
    • (2015) N Engl J Med , vol.373 , Issue.3 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 39
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373(23):2247–2257.
    • (2015) N Engl J Med , vol.373 , Issue.23 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 40
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373(22):2117–2128.
    • (2015) N Engl J Med , vol.373 , Issue.22 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 41
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311–322.
    • (2016) N Engl J Med , vol.375 , Issue.4 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 42
    • 84994813253 scopus 로고    scopus 로고
    • Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
    • Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375(19):1834–1844.
    • (2016) N Engl J Med , vol.375 , Issue.19 , pp. 1834-1844
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 43
    • 84871260146 scopus 로고    scopus 로고
    • Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis
    • Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012;60(25):2631–2639.
    • (2012) J Am Coll Cardiol , vol.60 , Issue.25 , pp. 2631-2639
    • Ference, B.A.1    Yoo, W.2    Alesh, I.3
  • 44
    • 84897489404 scopus 로고    scopus 로고
    • Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes
    • Miao F, Chen Z, Genuth S, et al. Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes. Diabetes. 2014;63(5):1748–1762.
    • (2014) Diabetes , vol.63 , Issue.5 , pp. 1748-1762
    • Miao, F.1    Chen, Z.2    Genuth, S.3
  • 45
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205(10):2409–2417.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3
  • 46
    • 80053559849 scopus 로고    scopus 로고
    • Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
    • Pirola L, Balcerczyk A, Tothill RW, et al. Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res. 2011;21(10):1601–1615.
    • (2011) Genome Res , vol.21 , Issue.10 , pp. 1601-1615
    • Pirola, L.1    Balcerczyk, A.2    Tothill, R.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.