Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 8, 2017, Pages

  Todd, Daniel A ^a   Parlet, Corey P ^b   Crosby, Heidi A ^b   Malone, Cheryl L ^b   Heilmann, Kristopher P ^b   Horswill, Alexander R ^b,c   Cech, Nadja B ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Agr system; Ambuic acid; Inhibitors; Staphylococcus aureus; Virulence regulation

Indexed keywords

AMBUIC ACID; ANTIBIOTIC AGENT; AUTOINDUCING PEPTIDE; BACTERIAL PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; AGRD PROTEIN, STAPHYLOCOCCUS; ANTIINFECTIVE AGENT; CYCLOHEXANONE DERIVATIVE; CYCLOPEPTIDE; VIRULENCE FACTOR;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENTEROCOCCUS FAECALIS; IC50; IN VIVO STUDY; LISTERIA MONOCYTOGENES; MALE; MASS SPECTROMETRY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; QUORUM SENSING; REAL TIME POLYMERASE CHAIN REACTION; REGULON; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS LUGDUNENSIS; STAPHYLOCOCCUS SAPROPHYTICUS; TREATMENT OUTCOME; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; GRAM POSITIVE BACTERIUM; GRAM POSITIVE INFECTION; HUMAN; MICROBIOLOGY; PATHOGENICITY; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS INFECTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYCLOHEXANONES; DISEASE MODELS, ANIMAL; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED BALB C; PEPTIDES, CYCLIC; QUORUM SENSING; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; VIRULENCE FACTORS;

EID: 85026374101     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00263-17     Document Type: Article

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