Iron fortified complementary foods containing a mixture of sodium iron EDTA with either ferrous fumarate or ferric pyrophosphate reduce iron deficiency anemia in 12- to 36-month-old children in a malaria endemic setting: A secondary analysis of a cluster-randomized controlled trial

Nutrients

Volumn 9, Issue 7, 2017, Pages

  Glinz, Dominik ^a,b,c   Wegmüller, Rita ^a   Ouattara, Mamadou ^d,e   Diakité, Victorine G ^e,f   Aaron, Grant J ^g   Hofer, Lorenz ^h   Zimmermann, Michael B ^a   Adiossan, Lukas G ⁱ   Utzinger, Jürg ^c,h   N’Goran, Eliézer K ^d,e   Hurrell, Richard F ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITÉ FÉLIX HOUPHOUËT BOIGNY   (Côte d’Ivoire)

^e CENTRE SUISSE DE RECHERCHES SCIENTIFIQUES EN CÔTE D'IVOIRE   (Côte d’Ivoire)

^f Université Alassane Ouattara de Bouaké   (Côte d’Ivoire)

^g GLOBAL ALLIANCE FOR IMPROVED NUTRITION   (Switzerland)

^h SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

ⁱ Hôpital Général de Taabo   (Côte d’Ivoire)

Author keywords

Anemia; Cluster randomized controlled trial; Complementary food; C te d Ivoire; Infant cereal; Iron deficiency; Iron fortification; Plasmodium falciparum; Sodium iron EDTA

Indexed keywords

C REACTIVE PROTEIN; EDETIC ACID; FERRIC PYROPHOSPHATE; FERROUS FUMARATE; HEMOGLOBIN; IRON; OROSOMUCOID; PLACEBO; SODIUM; FE(III)-EDTA; FERRIC ION; FERRITIN; FERROUS ION; PYROPHOSPHORIC ACID DERIVATIVE;

AFRICA SOUTH OF THE SAHARA; ANEMIA; ANTHROPOMETRY; ARTICLE; ASCARIASIS; BIOCHEMICAL ANALYSIS; CHILD; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; FORTIFIED FOOD; HUMAN; INFLAMMATION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALARIA RAPID TEST; MALE; MULTICENTER STUDY; PARASITEMIA; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHISTOSOMIASIS HAEMATOBIA; SECONDARY ANALYSIS; ADMINISTRATION AND DOSAGE; ANALYSIS; BLOOD; CLUSTER ANALYSIS; COMPLICATION; COTE D'IVOIRE; ENDEMIC DISEASE; INFANT; INFANT NUTRITION; INTESTINE ABSORPTION; IRON INTAKE; MAIZE; PHARMACOLOGY; SOYBEAN;

ANEMIA, IRON-DEFICIENCY; CHILD, PRESCHOOL; CLUSTER ANALYSIS; COTE D'IVOIRE; DIPHOSPHATES; EDETIC ACID; ENDEMIC DISEASES; FERRIC COMPOUNDS; FERRITINS; FERROUS COMPOUNDS; FOOD, FORTIFIED; HEMOGLOBINS; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INTESTINAL ABSORPTION; IRON; IRON, DIETARY; MALARIA, FALCIPARUM; SOYBEANS; ZEA MAYS;

EID: 85025113174     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9070759     Document Type: Article

References (36)

1. World Health Organization (WHO). Worldwide Prevalence of Anaemia 1993-2005; World Health Organization: Geneva, Switzerland, 2008.
2. Righetti, A.A.; Koua, A.Y.G.; Adiossan, L.G.; Glinz, D.; Hurrell, R.F.; N’Goran, E.K.; Niamké, S.; Wegmüller, R.; Utzinger, J. Etiology of anemia among infants, school-aged children, and young non-pregnant women in different settings of south-central Côte d’Ivoire. Am. J. Trop. Med. Hyg. 2012, 87, 425-434, doi:ajtmh.2012.11-0788.
3. Lozoff, B.; Georgieff, M.K. Iron deficiency and brain development. Semin. Pediatr. Neurol. 2006, 13, 158-165, doi:10.1016/j.spen.2006.08.004.
4. Shafir, T.; Angulo-Barroso, R.; Jing, Y.; Angelilli, M.L.; Jacobson, S.W.; Lozoff, B. Iron deficiency and infant motor development. Early Hum. Dev. 2008, 84, 479-85, doi:10.1016/j.earlhumdev.2007.12.009.
5. Hurrell, R.; Egli, I. Iron bioavailability and dietary reference values. Am. J. Clin. Nutr. 2010, 91, 1461S-1467S, doi:10.3945/ajcn.2010.28674F.
6. Hurrell, R.F. Fortification: Overcoming technical and practical barriers. J. Nutr. 2002, 132 (Suppl. 4), 806S-812S.
7. Food and Agriculture Organization (FAO)/World Health Organization (WHO). Guidelines on Food Fortification with Micronutrients; World Health Organization: Geneva, Switzerland, 2006.
8. World Health Organization (WHO). Evaluation of Certain Food Additives and Contaminants; WHO Technical Report Series Fifty-Third Report of the Joint FAO/WHO Expert Committee on Food Additives; World Health Organization: Geneva, Switzerland, 2000.
9. Cercamondi, C.I.; Egli, I.M.; Ahouandjinou, E.; Dossa, R.; Zeder, C.; Salami, L.; Tjalsma, H.; Wiegerinck, E.; Tanno, T.; Hurrell, R.F.; et al. Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: A double stable-isotope study in young Beninese women. Am. J. Clin. Nutr. 2010, 92, 1385-1392, doi:10.3945/ajcn.2010.30051.
10. Glinz, D.; Hurrell, R.F.; Righetti, A.A.; Zeder, C.; Adiossan, L.G.; Tjalsma, H.; Utzinger, J.; Zimmermann, M.B.; N’Goran, E.K.; Wegmüller, R. In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile Plasmodium falciparum infection reduces iron absorption by half. Am. J. Clin. Nutr. 2015, 101, 462-470, doi:10.3945/ajcn.114.090175.
11. Andang’o, P.E.; Osendarp, S.J.; Ayah, R.; West, C.E.; Mwaniki, D.L.; De Wolf, C.A.; Kraaijenhagen, R.; Kok, F.J.; Verhoef, H. Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: A randomised controlled trial. Lancet 2007, 369, 1799-8106, doi:10.1016/S0140-6736(07)60817-4.
12. Wegmüller, R.; Camara, F.; Zimmermann, M.B.; Adou, P.; Hurrell, R.F. Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Côte d’Ivoire. J. Nutr. 2006, 136, 1814-1820.
13. Zimmermann, M.B.; Wegmueller, R.; Zeder, C.; Chaouki, N.; Rohner, F.; Saissi, M.; Torresani, T.; Hurrell, R.F. Dual fortification of salt with iodine and micronized ferric pyrophosphate: A randomized, double-blind, controlled trial. Am. J. Clin. Nutr. 2004, 80, 952-959.
14. Rohner, F.; Zimmermann, M.B.; Amon, R.J.; Vounatsou, P.; Tschannen, A.B.; N’Goran, E.K.; Nindjin, C.; Cacou, M.C.; Té-Bonlé, M.D.; Aka, H.; et al. In a randomized controlled trial of iron fortification, anthelmintic treatment, and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit. J. Nutr. 2010, 140, 635-641, doi:10.3945/jn.109.114256.
15. Glinz, D.; Hurrell, R.F.; Ouattara, M.; Zimmermann, M.B.; Brittenham, G.M.; Adiossan, L.G.; Righetti, A.A.; Seifert, B.; Diakité, V.G.; Utzinger, J.; et al. The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: A cluster-randomised controlled trial. Malar. J. 2015, 14:347, doi:10.1186/s12936-015-0872-3.
16. Fürst, T.; Silué, K.D.; Ouattara, M.; N’Goran, D.N.; Adiossan, L.G.; N’Guessan, Y.; Zouzou, F.; Koné, S.; N’Goran, E.K.; Utzinger, J. Schistosomiasis, soil-transmitted helminthiasis, and sociodemographic factors influence quality of life of adults in Cote d’Ivoire. PLoS Negl. Trop. Dis. 2012, 6, e1855, doi:10.1371/journal.pntd.0001855.
17. Koné, S.; Baikoro, N.; N’Guessan, Y.; Jaeger, F.N.; Silué, K.D.; Fürst, T.; Hürlimann, E.; Ouattara, M.; Séka, M.C.; N’Guessan, N.A.; et al. Health & Demographic Surveillance System Profile: The Taabo Health and Demographic Surveillance System, Cote d’Ivoire. Int. J. Epidemiol. 2015, 44, 87-97, doi:10.1093/ije/dyu221.
18. Bassa, F.K.; Ouattara, M.; Silué, K.D.; Adiossan, L.G.; Baikoro, N.; Koné, S.; N’Cho, M.; Traoré, M.; Bonfoh, B.; Utzinger, J.; et al. Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Cote d’Ivoire. Malar. J. 2016, 15, 9, doi:10.1186/s12936-015-1076-6.
19. Righetti, A.A.; Wegmüller, R.; Glinz, D.; Ouattara, M.; Adiossan, L.G.; N’Goran, E.K.; Utzinger, J.; Hurrell, R.F. Effects of inflammation and Plasmodium falciparum infection on soluble transferrin receptor and plasma ferritin concentration in different age groups: A prospective longitudinal study in Côte d’Ivoire. Am. J. Clin. Nutr. 2013, 97, 1364-1374, doi:10.3945/ajcn.112.050302.
20. Staubli Asobayire, F. Development of a Food Fortification Strategy to Combat Iron Deficiency in the IVORY Coast; ETH Zurich: Zürich, Switzerland, 2000; pp. 1-239.
21. Wegmüller, R. Dual Fortification of Salt with Iodine and Iron in Africa; ETH Zurich: Zürich, Switzerland, 2005; pp. 1-211.
22. World Health Organization (WHO). Iron Deficiency Anaemia: Assessment, Prevention and Control: A Guide for Programme Managers; World Health Organization: Geneva, Switzerland, 2001.
23. Word Health Organization (WHO). Assessing the Iron Status of Populations, 2nd ed.; Word Health Organization, Centers for Disease Control and Prevention: Geneva, Switzerland, 2007.
24. Glinz, D.; Kamiyango, M.; Phiri, K.S.; Munthali, F.; Zeder, C.; Zimmermann, M.B.; Hurrell, R.F.; Wegmuller, R. The effect of timing of iron supplementation on iron absorption and haemoglobin in post-malaria anaemia: A longitudinal stable isotope study in Malawian toddlers. Malar. J. 2014, 13, 397, doi:10.1186/1475-2875-13-397.
25. Bezwoda, W.R.; Bothwell, T.H.; Torrance, J.D.; MacPhail, A.P.; Charlton, R.W.; Kay, G.; Levin, J. The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand. J. Haematol. 1979, 22, 113-120.
26. Collings, R.; Harvey, L.J.; Hooper, L.; Hurst, R.; Brown, T.J.; Ansett, J.; King, M.; Fairweather-Tait, S.J. The absorption of iron from whole diets: A systematic review. Am. J. Clin. Nutr. 2013, 98, 65-81, doi:10.3945/ajcn.112.050609.
27. Pasricha, S.R.; Atkinson, S.H.; Armitage, A.E.; Khandwala, S.; Veenemans, J.; Cox, S.E.; Eddowes, L.A.; Hayes, T.; Doherty, C.P.; Demir, A.Y.; et al. Expression of the iron hormone hepcidin distinguishes different types of anemia in african children. Sci. Transl. Med. 2014, 6, 235re3, doi:10.1126/scitranslmed.3008249.
28. Ganz, T. Macrophages and systemic iron homeostasis. J. Innate Immun. 2012, 4, 446-453, doi:10.1159/000336423.
29. Drakesmith, H.; Prentice, A.M. Hepcidin and the iron-infection axis. Science 2012, 338, 768-772, doi:10.1126/science.1224577.
30. Skorokhod, O.A.; Caione, L.; Marrocco, T.; Migliardi, G.; Barrera, V.; Arese, P.; Piacibello, W.; Schwarzer, E. Inhibition of erythropoiesis in malaria anemia: Role of hemozoin and hemozoin-generated 4-hydroxynonenal. Blood 2010, 116, 4328-4337, doi:10.1182/blood-2010-03-272781.
31. Pasricha, S.R.; Hayes, E.; Kalumba, K.; Biggs, B.A. Effect of daily iron supplementation on health in children aged 4-23 months: A systematic review and meta-analysis of randomised controlled trials. Lancet Glob. Health 2013, 1, 77-86.
32. De-Regil, L.M.; Suchdev, P.S.; Vist, G.E.; Walleser, S.; Pena-Rosas, J.P. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Evid. Based Child Health 2013, 8, 112-201, doi:10.1002/ebch.1895.
33. Hurrell, R.F. Iron fortification: Its efficacy and safety in relation to infections. Food Nutr. Bull. 2007, 28 (Suppl. 4), S585-S594.
34. Brittenham, G.M.; Andersson, M.; Egli, I.; Foman, J.T.; Zeder, C.; Westerman, M.E.; Hurrell, R.F. Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: A randomized study. Am. J. Clin. Nutr. 2014, 100, 813-820, doi:10.3945/ajcn.113.081505.
35. Jaeggi, T.; Kortman, G.A.; Moretti, D.; Chassard, C.; Holding, P.; Dostal, A.; Boekhorst, J.; Timmerman, H.M.; Swinkels, D.W.; Tjalsma, H.; et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2014, 64, 731-742, doi:10.1136/gutjnl-2014-307720.
36. Suchdev, P.S.; Namaste, S.M.; Aaron, G.J.; Raiten, D.J.; Brown, K.H.; Flores-Ayala, R. Overview of the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA). Project. Adv. Nutr. 2016, 7, 349-56, doi:10.3945/an.115.010215.