Infected malnourished children displayed changes in early activation and lymphocyte subpopulations

Acta Paediatrica, International Journal of Paediatrics

Volumn 106, Issue 9, 2017, Pages 1499-1506

  Nájera Medina, Oralia ^a   Valencia Chavarría, Fernando ^b   Cortés Bejar, Consuelo ^b   Palacios Martínez, Monika ^a   Rodríguez López, C Paulina ^c   González Torres, María Cristina ^c  

^a DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^b SECRETARÍA DE SALUD   (Mexico)

^c DEPARTAMENTO DE QUÍMICA   (Mexico)

Author keywords

Immunological deficiency; Infections; Lymphocyte activation; Malnutrition; Memory cells

Indexed keywords

CD45RA ANTIGEN; CD45RO ANTIGEN; CD69 ANTIGEN;

ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; INFANT; INFECTION; LYMPHOCYTE ACTIVATION; MALE; MALNUTRITION; MEMORY CELL; MEXICO CITY; NATURAL KILLER CELL; PRIORITY JOURNAL; COMPLICATION; IMMUNOLOGY; NUTRITIONAL DISORDER; PRESCHOOL CHILD;

CHILD NUTRITION DISORDERS; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFECTION; LYMPHOCYTE ACTIVATION; MALE;

EID: 85025093051     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.13930     Document Type: Article

References (27)

1. UNICEF. Improving child nutrition. The achievable imperative for global progress. Neva York: UNICEF. Available at: http://www.unicef.org/media/files/nutrition_report_2013.pdf.
2. Chandra RK. Nutrition and immunology: from the clinic to cellular biology and back again. Proc Nutr Soc 1999; 58: 681–3.
3. França TGD, Ishikawa LLW, Zorzella-Pezavento SFG, Chiuso-Minicucci F, de Cunha MLRS, Sartori A. Impact of malnutrition on immunity and infection. J Venom Anim Toxins Incl Trop Dis 2009; 15: 374–90.
4. Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr 1997; 66: 460–3.
5. Nájera O, González C, Toledo G, Cortés E, López L, Betancourt M, et al. Early activation of T, B and NK lymphocytes in infected malnourished and infected well-nourished children. J Nutr Immunol 2001; 5: 85–97.
6. Nájera O, González C, Toledo G, López L, Ortiz R. Flow cytometry study of lymphocyte subsets in malnourished and well-nourished children with bacterial infection. Clin Diagn Lab Immunol 2004; 11: 577–80.
7. Moore TV, Clay BS, Ferreira CM, Williams JW, Rogozinska M, Cannon JL, et al. Protective effector memory CD4 T cells depend on ICOS for survival. PLoS ONE 2011; 6: e16529.
8. Gómez F, Ramos GR, Frenk SM, Cravioto J, Chávez R, Vázquez J. Mortality in second and third degree malnutrition. Bull WHO 2000; 78: 1275–80.
9. Schaible UE, Kaufmann SHE. Malnutrition and infection: complex mechanisms and global impacts. PLoS Med 2007; 4: 806–12.
10. Lesourd BM, Mazari L. Immune responses during recovery from protein-energy malnutrition. Clin Nutr 1997; 16: 37–46.
11. Nassar MF, Younis NT, Tohamy AG, Dalam DM, El Badawy MA. T-lymphocyte subsets and thymic size in malnourished infants in Egypt: a hospital-based study. East Mediterr Health J 2007; 13: 1031–42.
12. Dewan P, Kaur I, Chattopadhya D, Faridi MM, Agarwal KN. A pilot study on the effects of curd (dahi) & leaf protein concentrate in children with protein energy malnutrition (PEM). Indian J Med Res 2007; 126: 199–203.
13. Sevilla R, Sejas E, Zelles L, Belmonte G, Chevalier P, Parent G, et al. The, “clapsen” a global approach for the nutritional rehabilitation of the severely malnourished child in Bolivia. Santé 2000; 10: 97–102.
14. Savino W, Dardenne M, Velloso LA, Silva-Barbosa SD. The thymus is a common target in malnutrition and infection. Br J Nutr 2007; 98: 511–6.
15. Sancho D, Gómez M, Sánchez-Madrid F. CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 2005; 26: 136–40.
16. Vazquez BN, Laguna T, Carabana J, Krangel MS, Lauzurica P. CD69 gene is differentially regulated T and B cells by evolutionarily conserved promoter-distal elements. J immunol 2009; 183: 6513–621.
17. Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol 2007; 25: 171–92.
18. Wagner C, Kotsougiani D, Pioch M, Prior B, Wentzensen A, Hänsch GM. T lymphocytes in acute bacterial infection: increased prevalence of CD11b cells in the peripheral blood and recruitment to the infected site. Immunol 2008; 125: 503–9.
19. Haring JS, Badovinac VP, Harty JT. Inflaming the CD8+ T cell response. Immunity 2006; 25: 19–29.
20. MacLeod MKL, Kappler JW, Marrack P. Memory CD4 T cells: generation, reactivation and re-assignment. Immunol 2010; 130: 10–5.
21. McLennan ICM, Gulbranson-Judge A, Toellner KM, Casamayor-Palleja M, Sze DMY, Chan EYT, et al. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol Rev 1997; 156: 53–66.
22. González-Martínez H, Rodríguez L, Nájera O, Cruz D, Miliar A, Domínguez A, et al. Expression of cytokine mRNA in lymphocytes of malnourished children. J Clin Immunol 2008; 28: 593–9.
23. González-Torres C, González-Martínez H, Miliar A, Nájera O, Graniel J, Firo V, et al. Effect of malnutrition on the expression of cytokines involved in Th1 cell differentiation. Nutrients 1033; 2013: 579–93.
24. Palacios-Martínez M, González-Torres MC, Rodríguez-Cruz L, Martínez-Pérez RD, Cortés-Bejar CC, Valencia-Chavarría F, et al. Memory and effector cells in children with bacterial infections of the gastrointestinal and respiratory tract. O J Immunol 2012; 2: 202–9.
25. Nájera MO, González TMC, Toledo G, López L, Cortés E, Betancourt M, et al. CD45RA and CD45RO isoforms in infected malnourished and infected well-nourished children. Clin Exp Immunol 2001; 126: 461–5.
26. Small CL, McCormick S, Gill N, Kugathasan K, Santosuosso M, Donaldson N, et al. NK cells play a critical protective role in host defense again acute extracellular Staphylococcus aureus bacterial infection in the lung. J Immunol 2008; 180: 5558–68.
27. Hiromatsu T, Yajima T, Matsuguch H, Nishimura H, Waijwalku W, Aria T, et al. Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-α-induced apoptosis. J Infect Dis 2003; 187: 1442–51.