-
1
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002;417: 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
2
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA, Fridlyand J, Kageshita T et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005;353:2135-2147.
-
(2005)
N Engl J Med
, vol.353
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
-
3
-
-
84962486398
-
Overall survival and durable responses in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib combined with trametinib
-
Long GV, Weber JS, Infante JR et al. Overall survival and durable responses in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib combined with trametinib. J Clin Oncol 2016; 34:871-878.
-
(2016)
J Clin Oncol
, vol.34
, pp. 871-878
-
-
Long, G.V.1
Weber, J.S.2
Infante, J.R.3
-
4
-
-
84938739283
-
Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial
-
Long GV, Stroyakovskiy D, Gogas H et al. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial. Lancet 2015;386:444-451.
-
(2015)
Lancet
, vol.386
, pp. 444-451
-
-
Long, G.V.1
Stroyakovskiy, D.2
Gogas, H.3
-
5
-
-
84920394727
-
Improved overall survival in melanoma with combined dabrafenib and trametinib
-
Robert C, Karaszewska B, Schachter J et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2015;372:30-39.
-
(2015)
N Engl J Med
, vol.372
, pp. 30-39
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
-
6
-
-
84994499942
-
Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (CoBRIM): Updated efficacy results from a randomised, double-blind, phase 3 trial
-
Ascierto PA, McArthur GA, Dreno B et al. Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): Updated efficacy results from a randomised, double-blind, phase 3 trial. Lancet Oncol 2016;17:1248-1260.
-
(2016)
Lancet Oncol
, vol.17
, pp. 1248-1260
-
-
Ascierto, P.A.1
McArthur, G.A.2
Dreno, B.3
-
7
-
-
85011645320
-
Results of COLUMBUS part 1: A phase 3 trial of encorafenib (ENCO) plus binimetinib (BINI) versus vemurafenib (VEM) or ENCO in BRAF-mutant melanoma
-
November 6-9, Boston, MA
-
Dummer R, Ascierto PA, Gogas HJ et al. Results of COLUMBUS part 1: A phase 3 trial of encorafenib (ENCO) plus binimetinib (BINI) versus vemurafenib (VEM) or ENCO in BRAF-mutant melanoma. Paper presented at: 13th International Congress of the Society for Melanoma Research; November 6-9, 2016; Boston, MA.
-
(2016)
Paper Presented At: 13Th International Congress of the Society for Melanoma Research
-
-
Dummer, R.1
Ascierto, P.A.2
Gogas, H.J.3
-
8
-
-
84938842856
-
-
NJ: Novartis Pharmaceuticals Corporation
-
Tafinlar (dabrafenib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015.
-
(2015)
East Hanover
-
-
-
9
-
-
84938842856
-
-
NJ: Novartis Pharmaceuticals Corporation
-
Mekinist (trametinib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015.
-
(2015)
East Hanover
-
-
-
10
-
-
85024113151
-
-
South San Francisco, CA: Genentech USA, Inc
-
Zelboraf (vemurafenib) [package insert]. South San Francisco, CA: Genentech USA, Inc; 2015.
-
(2015)
-
-
-
11
-
-
85024130809
-
-
South San Francisco, CA: Genentech USA, Inc
-
Cotellic (cobimetinib) [package insert]. South San Francisco, CA: Genentech USA, Inc; 2015.
-
(2015)
-
-
-
12
-
-
84864285704
-
Dabrafenib in BRAF-mutatedmetastatic melanoma:Amulticentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV et al. Dabrafenib in BRAF-mutatedmetastatic melanoma:Amulticentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380:358-365.
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
13
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364: 2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
14
-
-
84863673204
-
Improved survival with MEK inhibition in BRAF-mutated melanoma
-
Flaherty KT, Robert C, Hersey P et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl JMed 2012;367:107-114.
-
(2012)
N Engl Jmed
, vol.367
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
15
-
-
84946508118
-
Updated overall survival for BRF113220: A phase 1-2 study of dabrafenib alone vs combined dabrafenib and trametinib in patients with BRAF V600 mutation-positive metastatic melanoma
-
Daud A, Weber J, Sosman J et al. Updated overall survival for BRF113220: A phase 1-2 study of dabrafenib alone vs combined dabrafenib and trametinib in patients with BRAF V600 mutation-positive metastatic melanoma. J Clin Oncol 2015;33: 9036a.
-
(2015)
J Clin Oncol
, pp. 33
-
-
Daud, A.1
Weber, J.2
Sosman, J.3
-
16
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl JMed 2012;367:1694-1703.
-
(2012)
N Engl Jmed
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
17
-
-
84908257665
-
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma
-
Long GV, Stroyakovskiy D, Gogas H et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med 2014;371: 1877-1888.
-
(2014)
N Engl J Med
, vol.371
, pp. 1877-1888
-
-
Long, G.V.1
Stroyakovskiy, D.2
Gogas, H.3
-
18
-
-
84994398716
-
Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D)1trametinib (T) vs D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/ K-mutant cutaneous melanoma
-
Flaherty K, Davies MA, Grob J et al. Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D)1trametinib (T) vs D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/ K-mutant cutaneous melanoma. J Clin Oncol 2016; 34:9502a.
-
(2016)
J Clin Oncol
, pp. 34
-
-
Flaherty, K.1
Davies, M.A.2
Grob, J.3
-
19
-
-
84977929608
-
Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma
-
Robert C, Karaszewska B, Schachter J et al. Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma. Eur J Cancer 2015;51(suppl 3):3301a.
-
(2015)
Eur J Cancer
, vol.51
, pp. 3301
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
-
20
-
-
84908245075
-
Combined vemurafenib and cobimetinib in BRAF-mutatedmelanoma
-
Larkin J, Ascierto PA, Dréno B et al. Combined vemurafenib and cobimetinib in BRAF-mutatedmelanoma. N Engl J Med 2014;371:1867-1876.
-
(2014)
N Engl J Med
, vol.371
, pp. 1867-1876
-
-
Larkin, J.1
Ascierto, P.A.2
Dréno, B.3
-
21
-
-
85042694330
-
Pooled analysis of safety over time and link between adverse events and efficacy across combination dabrafenib and trametinib (D1T) registration trials
-
Grob JJ, Flaherty K, Long GV et al. Pooled analysis of safety over time and link between adverse events and efficacy across combination dabrafenib and trametinib (D1T) registration trials. J Clin Oncol 2016;34:9534a.
-
(2016)
J Clin Oncol
, pp. 34
-
-
Grob, J.J.1
Flaherty, K.2
Long, G.V.3
-
22
-
-
85037850149
-
Adverse event (AE) incidence rates with cobimetinib (C) plus vemurafenib (V) treatment: Extended follow-up (f/u) of the phase III coBRIM study
-
Dréno B, Ascierto PA, McArthur GA et al. Adverse event (AE) incidence rates with cobimetinib (C) plus vemurafenib (V) treatment: Extended follow-up (f/u) of the phase III coBRIM study. J Clin Oncol 2016;34:9533a.
-
(2016)
J Clin Oncol
, pp. 34
-
-
Dréno, B.1
Ascierto, P.A.2
McArthur, G.A.3
-
23
-
-
84977929608
-
Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma
-
September 25-29, Vienna, Austria
-
Robert C, Karaszewska B, Schachter J et al. Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma. Paper presented at: 18th Annual European Cancer Congress (ECCO) and European Society of Medical Oncology 2015 Annual Meeting; September 25-29, 2015; Vienna, Austria.
-
(2015)
Paper Presented At: 18Th Annual European Cancer Congress (ECCO) and European Society of Medical Oncology 2015 Annual Meeting
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
-
24
-
-
84907865088
-
A case of intracranial hemorrhage caused by combined dabrafenib and trametinib therapy for metastatic melanoma
-
Lee le M, Feun L, Tan Y. A case of intracranial hemorrhage caused by combined dabrafenib and trametinib therapy for metastatic melanoma. Am J Case Rep 2014;15:441-443.
-
(2014)
Am J Case Rep
, vol.15
, pp. 441-443
-
-
Lee Le, M.1
Feun, L.2
Tan, Y.3
-
25
-
-
84955170054
-
Hepatic hemorrhage as a consequence of rapid response to combined targeted therapy inmetastaticmelanoma
-
Flaherty DC, Hoffner BW, Lau BJ et al. Hepatic hemorrhage as a consequence of rapid response to combined targeted therapy inmetastaticmelanoma. J Surg Oncol 2015;112:844-845.
-
(2015)
J Surg Oncol
, vol.112
, pp. 844-845
-
-
Flaherty, D.C.1
Hoffner, B.W.2
Lau, B.J.3
-
26
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, openlabel study
-
McArthur GA, Chapman PB, Robert C et al. Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, openlabel study. Lancet Oncol 2014;15:323-332.
-
(2014)
Lancet Oncol
, vol.15
, pp. 323-332
-
-
McArthur, G.A.1
Chapman, P.B.2
Robert, C.3
-
27
-
-
84933183142
-
A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies
-
Chan A, Cameron MC, Garden B et al. A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies. Support Care Cancer 2015;23:2231-2244.
-
(2015)
Support Care Cancer
, vol.23
, pp. 2231-2244
-
-
Chan, A.1
Cameron, M.C.2
Garden, B.3
-
28
-
-
84942987653
-
BRAF, MEK and KIT inhibitors for melanoma: Adverse events and their management
-
Livingstone E, Zimmer L, Vaubel J et al. BRAF, MEK and KIT inhibitors for melanoma: Adverse events and their management. Chin Clin Oncol 2014;3:29.
-
(2014)
Chin Clin Oncol
, vol.3
, pp. 29
-
-
Livingstone, E.1
Zimmer, L.2
Vaubel, J.3
-
29
-
-
84944350959
-
Cutaneous toxic effects of BRAF inhibitors alone and in combination withMEK inhibitors for metastatic melanoma
-
Carlos G, Anforth R, Clements A et al. Cutaneous toxic effects of BRAF inhibitors alone and in combination withMEK inhibitors for metastatic melanoma. JAMA Dermatol 2015;151:1103-1109.
-
(2015)
JAMA Dermatol
, vol.151
, pp. 1103-1109
-
-
Carlos, G.1
Anforth, R.2
Clements, A.3
-
30
-
-
84903159476
-
Targeting RAF kinases for cancer therapy: BRAFmutated melanoma and beyond
-
Holderfield M, Deuker MM, McCormick F et al. Targeting RAF kinases for cancer therapy: BRAFmutated melanoma and beyond. Nat Rev Cancer 2014;14:455-467.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 455-467
-
-
Holderfield, M.1
Deuker, M.M.2
McCormick, F.3
-
31
-
-
84924811524
-
Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma
-
Welsh SJ, Corrie PG. Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma. Ther AdvMed Oncol 2015;7:122-136.
-
(2015)
Ther Advmed Oncol
, vol.7
, pp. 122-136
-
-
Welsh, S.J.1
Corrie, P.G.2
-
32
-
-
84938207532
-
Comparative profile of cutaneous adverse events: BRAF/ MEK inhibitor combination therapy versus BRAF monotherapy in melanoma
-
Sanlorenzo M, Choudhry A, Vujic I et al. Comparative profile of cutaneous adverse events: BRAF/ MEK inhibitor combination therapy versus BRAF monotherapy in melanoma. J Am Acad Dermatol 2014;71:1102-1109.e1.
-
(2014)
J am Acad Dermatol
, vol.71
, pp. 1102-1109
-
-
Sanlorenzo, M.1
Choudhry, A.2
Vujic, I.3
-
33
-
-
84879795966
-
Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma
-
Gibney GT, Messina JL, Fedorenko IV et al. Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma. Nat Rev Clin Oncol 2013;10: 390-399.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 390-399
-
-
Gibney, G.T.1
Messina, J.L.2
Fedorenko, I.V.3
-
34
-
-
84954161617
-
Multiple gastrointestinal polyps in patients treated with BRAF inhibitors
-
Amaravadi RK, Hamilton KE, Ma X et al. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clin Cancer Res 2015;21:5215-5221.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 5215-5221
-
-
Amaravadi, R.K.1
Hamilton, K.E.2
Ma, X.3
-
35
-
-
84878907330
-
Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities
-
van der Noll R, Leijen S, Neuteboom GH et al. Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities. Cancer Treat Rev 2013;39:664-672.
-
(2013)
Cancer Treat Rev
, vol.39
, pp. 664-672
-
-
Van Der Noll, R.1
Leijen, S.2
Neuteboom, G.H.3
-
36
-
-
84894151058
-
Bilateral multifocal central serous-like chorioretinopathy due to MEK inhibition for metastatic cutaneous melanoma
-
Schoenberger SD, Kim SJ. Bilateral multifocal central serous-like chorioretinopathy due to MEK inhibition for metastatic cutaneous melanoma. Case Rep OphthalmolMed 2013;2013:673796.
-
(2013)
Case Rep Ophthalmolmed
, pp. 2013
-
-
Schoenberger, S.D.1
Kim, S.J.2
-
37
-
-
84903700501
-
Transient MEK inhibitor-associated retinopathy in metastatic melanoma
-
Urner-Bloch U, Urner M, Stieger P et al. Transient MEK inhibitor-associated retinopathy in metastatic melanoma. Ann Oncol 2014;25:1437-1441.
-
(2014)
Ann Oncol
, vol.25
, pp. 1437-1441
-
-
Urner-Bloch, U.1
Urner, M.2
Stieger, P.3
-
38
-
-
85024107053
-
Retinal vein occlusion induced by a MEK inhibitor—Impact of oxidative stress on the blood-retinal barrier
-
In: Lushchak VI, Gospodaryov DV, eds., Rijeka, Croatia: InTech Open
-
Yang AH, Huang W. Retinal vein occlusion induced by a MEK inhibitor—Impact of oxidative stress on the blood-retinal barrier. In: Lushchak VI, Gospodaryov DV, eds. Biochemistry, Genetics and Molecular Biology: Oxidative Stress and Diseases. Rijeka, Croatia: InTech Open, 2013.
-
(2013)
Biochemistry, Genetics and Molecular Biology: Oxidative Stress and Diseases
-
-
Yang, A.H.1
Huang, W.2
-
39
-
-
84907332424
-
Bilateral subfoveal neurosensory retinal detachment associated with MEK inhibitor use for metastatic cancer
-
McCannel TA, Chmielowski B, Finn RS et al. Bilateral subfoveal neurosensory retinal detachment associated with MEK inhibitor use for metastatic cancer. JAMA Ophthalmol 2014;132: 1005-1009.
-
(2014)
JAMA Ophthalmol
, vol.132
, pp. 1005-1009
-
-
McCannel, T.A.1
Chmielowski, B.2
Finn, R.S.3
-
40
-
-
84893089529
-
Uveitis as a result of MAP kinase pathway inhibition
-
Joshi L, Karydis A, Gemenetzi M et al. Uveitis as a result of MAP kinase pathway inhibition. Case Rep Ophthalmol 2013;4:279-282.
-
(2013)
Case Rep Ophthalmol
, vol.4
, pp. 279-282
-
-
Joshi, L.1
Karydis, A.2
Gemenetzi, M.3
-
41
-
-
84930936403
-
Severe bilateral panuveitis during melanoma treatment by dabrafenib and trametinib
-
Draganova D, Kerger J, Caspers L et al. Severe bilateral panuveitis during melanoma treatment by dabrafenib and trametinib. J Ophthalmic Inflamm Infect 2015;5:17.
-
(2015)
J Ophthalmic Inflamm Infect
, vol.5
, pp. 17
-
-
Draganova, D.1
Kerger, J.2
Caspers, L.3
-
42
-
-
84904916223
-
Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: A phase 1b study
-
Ribas A, Gonzalez R, Pavlick A et al. Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: A phase 1b study. Lancet Oncol 2014;15:954-965.
-
(2014)
Lancet Oncol
, vol.15
, pp. 954-965
-
-
Ribas, A.1
Gonzalez, R.2
Pavlick, A.3
-
43
-
-
84926097366
-
Features andmanagement of pyrexia with combined dabrafenib and trametinib in metastatic melanoma
-
Lee CI, Menzies AM, Haydu LE et al. Features andmanagement of pyrexia with combined dabrafenib and trametinib in metastatic melanoma. Melanoma Res 2014;24:468-474.
-
(2014)
Melanoma Res
, vol.24
, pp. 468-474
-
-
Lee, C.I.1
Menzies, A.M.2
Haydu, L.E.3
-
44
-
-
84923927971
-
Characteristics of pyrexia in BRAFV600E/K metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial
-
Menzies AM, Ashworth MT, Swann S et al. Characteristics of pyrexia in BRAFV600E/K metastatic melanoma patients treated with combined dabrafenib and trametinib in a phase I/II clinical trial. Ann Oncol 2015;26:415-421.
-
(2015)
Ann Oncol
, vol.26
, pp. 415-421
-
-
Menzies, A.M.1
Ashworth, M.T.2
Swann, S.3
-
45
-
-
85024123495
-
-
Melanoma. V3.2016
-
NCCN Clinical Practice Guidelines in Oncology: Melanoma. V3.2016. Available at https://www.nccn.org/professionals/physician_gls/PDF/melanoma.pdf. Accessed August 9, 2016.
-
-
-
-
46
-
-
84875453915
-
Analysis of dermatologic events in vemurafenib-treated patients with melanoma
-
Lacouture ME, Duvic M, Hauschild A et al. Analysis of dermatologic events in vemurafenib-treated patients with melanoma. The Oncologist 2013;18: 314-322.
-
(2013)
The Oncologist
, vol.18
, pp. 314-322
-
-
Lacouture, M.E.1
Duvic, M.2
Hauschild, A.3
-
47
-
-
84868138286
-
Cutaneous adverse events associated with vemurafenib in patients with metastatic melanoma: Practical advice on diagnosis, prevention and management of the main treatment-related skin toxicities
-
Sinha R, Edmonds K, Newton-Bishop JA et al. Cutaneous adverse events associated with vemurafenib in patients with metastatic melanoma: Practical advice on diagnosis, prevention and management of the main treatment-related skin toxicities. Br J Dermatol 2012;167:987-994.
-
(2012)
Br J Dermatol
, vol.167
, pp. 987-994
-
-
Sinha, R.1
Edmonds, K.2
Newton-Bishop, J.A.3
-
48
-
-
84891317922
-
Characterization of vemurafenib phototoxicity in amouse model
-
Boudon SM, Plappert-Helbig U, Odermatt A et al. Characterization of vemurafenib phototoxicity in amouse model.Toxicol Sci 2014;137:259-267.
-
(2014)
Toxicol Sci
, vol.137
, pp. 259-267
-
-
Boudon, S.M.1
Plappert-Helbig, U.2
Odermatt, A.3
-
49
-
-
84856582443
-
Ultraviolet A and photosensitivity during vemurafenib therapy
-
Dummer R, Rinderknecht J, Goldinger SM. Ultraviolet A and photosensitivity during vemurafenib therapy. N Engl JMed 2012;366:480-481.
-
(2012)
N Engl Jmed
, vol.366
, pp. 480-481
-
-
Dummer, R.1
Rinderknecht, J.2
Goldinger, S.M.3
-
51
-
-
77149129262
-
PD0325901, a mitogen-activated protein kinase kinase inhibitor, produces ocular toxicity in a rabbit animal model of retinal vein occlusion
-
Huang W, Yang AH, Matsumoto D et al. PD0325901, a mitogen-activated protein kinase kinase inhibitor, produces ocular toxicity in a rabbit animal model of retinal vein occlusion. J Ocul Pharmacol Ther 2009;25:519-530.
-
(2009)
J Ocul Pharmacol Ther
, vol.25
, pp. 519-530
-
-
Huang, W.1
Yang, A.H.2
Matsumoto, D.3
-
52
-
-
84888379181
-
Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma
-
Wolf SE, Meenken C, Moll AC et al. Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma. BMC Cancer 2013;13: 561.
-
(2013)
BMC Cancer
, vol.13
, pp. 561
-
-
Wolf, S.E.1
Meenken, C.2
Moll, A.C.3
-
53
-
-
74049125665
-
Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics
-
Cheng H, Force T. Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res 2010;106:21-34.
-
(2010)
Circ Res
, vol.106
, pp. 21-34
-
-
Cheng, H.1
Force, T.2
-
54
-
-
34547482919
-
Clinical experience of MEK inhibitors in cancer therapy
-
Wang D, Boerner SA, Winkler JD et al. Clinical experience of MEK inhibitors in cancer therapy. Biochim Biophys Acta 2007;1773:1248-1255.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1248-1255
-
-
Wang, D.1
Boerner, S.A.2
Winkler, J.D.3
-
55
-
-
84939214546
-
Targeting precision medicine toxicity: Recent developments
-
Mallarkey G, Mangoni AA. Targeting precision medicine toxicity: Recent developments. Ther Adv Drug Saf 2015;6:4-14.
-
(2015)
Ther Adv Drug Saf
, vol.6
, pp. 4-14
-
-
Mallarkey, G.1
Mangoni, A.A.2
-
56
-
-
84936941910
-
Complete remission of metastatic melanoma upon BRAF inhibitor treatment—What happens after discontinuation?
-
Tolk H, Satzger I, Mohr P et al. Complete remission of metastatic melanoma upon BRAF inhibitor treatment—What happens after discontinuation? Melanoma Res 2015;25:362-366.
-
(2015)
Melanoma Res
, vol.25
, pp. 362-366
-
-
Tolk, H.1
Satzger, I.2
Mohr, P.3
-
57
-
-
84990177799
-
Cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma: A case series
-
Carlino MS, Vanella V, Girgis C et al. Cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma: A case series. Br J Cancer 2016;115:1280-1284.
-
(2016)
Br J Cancer
, vol.115
, pp. 1280-1284
-
-
Carlino, M.S.1
Vanella, V.2
Girgis, C.3
-
58
-
-
84886047746
-
The evolution of melanoma resistance reveals therapeutic opportunities
-
Das Thakur M, Stuart DD. The evolution of melanoma resistance reveals therapeutic opportunities. Cancer Res 2013;73:6106-6110.
-
(2013)
Cancer Res
, vol.73
, pp. 6106-6110
-
-
Das Thakur, M.1
Stuart, D.D.2
-
59
-
-
84922875490
-
Tunablecombinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction
-
Moriceau G, Hugo W, Hong A et al. Tunablecombinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction. Cancer Cell 2015;27: 240-256.
-
(2015)
Cancer Cell
, vol.27
, pp. 240-256
-
-
Moriceau, G.1
Hugo, W.2
Hong, A.3
-
60
-
-
84905825810
-
Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: Promise and challenges
-
Hu-Lieskovan S, Robert L, Homet Moreno B et al. Combining targeted therapy with immunotherapy in BRAF-mutant melanoma: Promise and challenges. J Clin Oncol 2014;32:2248-2254.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2248-2254
-
-
Hu-Lieskovan, S.1
Robert, L.2
Homet Moreno, B.3
-
61
-
-
84928226899
-
An update on overall survival (OS) and follow-on therapies in BREAK-3, a phase iii, randomized trial: Dabrafenib (D) vs. dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma (MM)
-
Hauschild A, Grob J, Demidov L et al. An update on overall survival (OS) and follow-on therapies in BREAK-3, a phase iii, randomized trial: Dabrafenib (D) vs. dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma (MM). Ann Oncol 2014;25:4374a.
-
(2014)
Ann Oncol
, vol.25
-
-
Hauschild, A.1
Grob, J.2
Demidov, L.3
-
62
-
-
84928226899
-
An update on overall survival (OS) and follow-on therapies in BREAK-3, a phase iii, randomized trial: Dabrafenib (D) vs. dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma (MM)
-
September 26-30, Madrid, Spain
-
Hauschild A, Grob J, Demidov L et al. An update on overall survival (OS) and follow-on therapies in BREAK-3, a phase iii, randomized trial: Dabrafenib (D) vs. dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma (MM). Poster presented at: European Society of Medical Oncology (ESMO) 2014 Annual Meeting; September 26-30, 2014; Madrid, Spain.
-
(2014)
Poster Presented At: European Society of Medical Oncology (ESMO) 2014 Annual Meeting
-
-
Hauschild, A.1
Grob, J.2
Demidov, L.3
|