Successful treatment of a patient with refractory nephrotic syndrome with PCSK9 inhibitors: A case report

BMC Nephrology

Volumn 18, Issue 1, 2017, Pages

  Awanami, Yuki ^a   Fukuda, Makoto ^a   Nonaka, Yasunori ^a   Takashima, Tsuyoshi ^a   Matsumoto, Keiichiro ^a   Yamasaki, Masatora ^a   Miyazono, Motoaki ^a   Ikeda, Yuji ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Case report; Evolocumab; Nephrotic syndrome; Proprotein convertase subtilisin kexin type 9 (PCSK9)

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALENDRONIC ACID; ALFACALCIDOL; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; CHOLESTEROL; CORTICOTROPIN; COTRIMOXAZOLE; CREATININE; CYCLOSPORIN A; EVOLOCUMAB; FAMOTIDINE; GUALENATE SODIUM; GUANOSINE TRIPHOSPHATASE; LACTATE DEHYDROGENASE; LIMAPROST; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PREDNISOLONE; PROPROTEIN CONVERTASE 9; CYCLOSPORINE; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN;

ADULT; ALLERGY; ARTICLE; CASE REPORT; CLINICAL FEATURE; CREATININE URINE LEVEL; DISEASE COURSE; DISORDERS OF LIPID METABOLISM; DRUG DOSE REDUCTION; FAMILY HISTORY; FEMALE; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; HYPERLIPIDEMIA; HYPOALBUMINEMIA; HYPOPROTEINEMIA; KIDNEY BIOPSY; LEG EDEMA; LEUKOCYTOSIS; NEPHROTIC SYNDROME; PROTEIN URINE LEVEL; PROTEINURIA; RELAPSE; REMISSION; SELECTIVITY INDEX; SINGLE DRUG DOSE; THORAX RADIOGRAPHY; ANTAGONISTS AND INHIBITORS; MIDDLE AGED; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; CYCLOSPORINE; FEMALE; HUMANS; MIDDLE AGED; NEPHROTIC SYNDROME; PREDNISOLONE; PROPROTEIN CONVERTASE 9; TREATMENT OUTCOME;

EID: 85022175915     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/s12882-017-0644-0     Document Type: Article

References (6)

1. Muso E, Mune M, Hirano T, Hattori M, Kimura K, Watababe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Yuzawa Y, Takemura T, Sugiyama S, Nishizawa Y, Ogahara S, Yorioka N, Sakai S, Ogura Y, Yukawa S, Iino Y, Imai E, Matsuo S, Saito T. Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS study. Clin Exp Nephrol. 2015 Jun;19(3):379-86.
2. Sandhu S, Wiebe N, Fried LF, Toinelli M. Statins for improving renal outcomes: a meta-analysis. J Am Soc Nephrol. 2006;17:2006-16.
3. Toth PP. Novel therapies for low-density lipoprotein cholesterol reduction. Am J Cardiol. 2016 Sep 15;118(6 Suppl):19A-32A.
4. Lieberman KV, Pavlova-Wolf A: Adrenocorticotropic hormone therapy for the treatment of idiopathic nephrotic syndrome in children and young adults: a systematic review of early clinical studies with contemporary relevance. J Nephrol. 2017;30:35-44.
5. Muso E. Beneficial effect of LDL-apheresis in refractory nephrotic syndrome. Clin Exp Nephrol. 2014;18:286-90.
6. Jin K, Park B-S, Kim Y-W, Vaziri ND. Plasma PCSK9 in nephrotic syndrome and in peritoneal dialysis: a cross-sectional study. Am J Kidney Dis. 2014;63(4):584-9.