Adrenocorticotropic hormone therapy for the treatment of idiopathic nephrotic syndrome in children and young adults: a systematic review of early clinical studies with contemporary relevance

Journal of Nephrology

Volumn 30, Issue 1, 2017, Pages 35-44

  Lieberman, Kenneth V ^a   Pavlova Wolf, Anna ^b  

^a HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

^b MALLINCKRODT PHARMACEUTICALS   (United States)

Author keywords

Adrenocorticotropic hormone; Nephrotic syndrome; Pediatric; Systematic review

Indexed keywords

CORTICOTROPIN;

ALBUMINURIA; DIURESIS; DRUG INTERMITTENT THERAPY; DRUG TOLERABILITY; EDEMA; FOLLOW UP; HORMONAL THERAPY; HUMAN; LONG TERM CARE; MORTALITY; NEPHROTIC SYNDROME; PROTEINURIA; REVIEW; SHORT COURSE THERAPY; SYSTEMATIC REVIEW; ADOLESCENT; ADULT; CHILD; YOUNG ADULT;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; CHILD; HUMANS; NEPHROTIC SYNDROME; YOUNG ADULT;

EID: 85013296158     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.1007/s40620-016-0308-3     Document Type: Review

References (52)

1. Berg AL, Nilsson-Ehle P, Arnadottir M (1999) Beneficial effects of ACTH on the serum lipoprotein profile and glomerular function in patients with membranous nephropathy. Kidney Int 56:1534–1543
2. Berg AL, Arnadottir M (2004) ACTH-induced improvement in the nephrotic syndrome in patients with a variety of diagnoses. Nephrol Dial Transplant 19:1305–1307
3. Ponticelli C, Passerini P, Salvadori M, Manno C, Viola BF, Pasquali S, Mandolfo S, Messa P (2006) A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy. Am J Kidney Dis 47:233–240
4. Bomback AS, Tumlin JA, Baranski J, Bourdeau JE, Besarab A, Appel AS, Radhakrishnan J, Appel GB (2011) Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel. Drug Des Devel Ther 5:147–153
5. Bomback AS, Canetta PA, Beck LH Jr, Ayalon R, Radhakrishnan J, Appel GB (2012) Treatment of resistant glomerular diseases with adrenocorticotropic hormone gel: a prospective trial. Am J Nephrol 36:58–67
6. Hogan J, Bomback AS, Mehta K, Canetta PA, Rao MK, Appel GB, Radhakrishnan J, Lafayette RA (2013) Treatment of idiopathic FSGS with adrenocorticotropic hormone gel. Clin J Am Soc Nephrol 8:2072–2081
7. ® Gel) in nephrotic syndrome due to idiopathic membranous nephropathy. Nephrol Dial Transplant 29:1570–1577
8. Tumlin JA, Galphin CM, Rovin BH (2013) Advanced diabetic nephropathy with nephrotic range proteinuria: a pilot study of the long-term efficacy of subcutaneous ACTH gel on proteinuria, progression of CKD, and urinary levels of VEGF and MCP-1. J Diabetes Res 2013:489869
9. ®: a case study. Int J Nephrol Renovasc Dis 6:229–232
10. Rance CP, Chute AL (1955) Treatment of the nephrotic syndrome in children. Can Med Assoc J 73:959–964
11. Kohn JL, Gribetz D (1960) Nephrotic syndrome of childhood. Comparison of results of current hormonal therapy with those achieved previously. Am J Dis Child 100:373–379
12. Brown RB, Burke EC, Stickler GB (1965) Studies in nephrotic syndrome. I. Survival of 135 children with nephrotic syndrome treated with adrenal steroids. Mayo Clin Proc 40:384–390
13. Durand P, DeToni E Jr (1955) Treatment of nephrotic syndrome in children. An Paediatr 185:225–235
14. Kramer B, Casden DD, Goldman H, Silverman SH (1952) Effect of the adrenocorticotropic hormone (ACTH) on nephrosis in childhood. Postgrad Med 11:439–446
15. Heidorn GH, Schemm FR (1955) The clinical use of corticotropin (ACTH) and adrenal corticosteroids in the therapy of intractable edema. Am J Med Sci 229:621–631
16. Heidorn GH, Schemm FR, Layne JA (1955) The varied patterns of water and sodium diuresis during corticotropin (ACTH) therapy of the nephrotic syndrome. Am J Med Sci 229:180–187
17. Mateer FM, Weigland FA, Greenman L, Weber J Jr, Kunkel GA, Danowski TS (1957) Corticotropin (ACTH) therapy of nephrotic syndrome in children. I. Clinical results and effects on proteinuria in one hundred six instances. J Dis Child 93:591–603
18. Riley CM, Davis RA, Fertig JW, Berger AP (1956) Nephrosis of childhood: statistical evaluation of the effect of adrenocortical-active therapy. J Chronic Dis 3:640–650
19. Massell BF, Warren JE, Sturgis JP (1950) Observations on effects of ACTH in patients with rheumatic fever and rheumatic carditis. In: Mote JR (ed) Proceedings of the first clinical ACTH conference. The Blackison Company, Philadelphia, PA, p 405
20. Farnsworth EB (1950) Studies on influence of adrenocorticotrophin in acute nephritis, in simple nephrosis and in nephrosis with azotemia. In: Mote JR (ed) Proceedings of the first clinical ACTH conference. Blakiston Company, Philadelphia, pp 297–317
21. Lauson HD, Forman CW, McNamara H, Mattar G, Barnett HL (1954) The effect of corticotropin (ACTH) on glomerular permeability to albumin in children with the nephrotic syndrome. J Clin Invest 33:657–664
22. Stickler GB, McKenzie BF, Wakim KG, Burke EC (1956) The effect of plasma transfusion and treatment with corticotropin on the electrophoretic patterns in serum and urine of children with the nephrotic syndrome. J Lab Clin Med 47:392–402
23. Hecker H, Stevens RE (1952) Nephrosis—a long remission after ACTH. RI Med J 35:81–84
24. Singh S (1952) Nephrotic syndrome treated with ACTH. Antiseptic 49:54–57
25. Bjorneboe M, Brun C, Gormsen H, Iversen P, Raaschou F (1952) The nephrotic syndrome. II. The effect of corticotropin ACTH. Acta Med Scand 142(suppl 266):249–265
26. McCall MF, Ross A, Wolman B, Burns AD, Harpur EM, Goldbloom A (1952) The nephrotic syndrome in children treated with A.C.T.H. and cortisone. Arch Dis Child 27:309–321
27. Rinvik R (1952) Corticotropin in the treatment of the nephrotic syndrome. J Oslo City Hosp 2:149–152
28. Aber GM, Chandler GN, Hartfall SJ (1954) Cortisone and A.C.T.H. in treatment of non-rheumatic conditions. Br Med J 1:1–8
29. Heymann W, Gilkey C, Salehar M (1955) Effect of adrenocorticotropic hormone (ACTH) and cortisone on proteinuria and hematuria in the nephrotic syndrome. Pediatrics 15:49–53
30. Dundon S (1957) Steroid therapy in the nephrotic syndrome. J Ir Med Assoc 40:135–144
31. Baskin JL (1956) Medical management of renal disease in infants and children. Tex State J Med 52:865–869
32. Charlton D, Latner AL, Platt JW, Smart GA, Thompson RB, Walker W (1958) The nephrotic syndrome. Observations of the effects of A.C.T.H. in 40 patients. Acta Med Scand 161:33–56
33. Eales L (1959) The effect of ACTH and the steroid drugs on the nephrotic syndrome. S Afr J Lab Clin Med 5:125–155
34. Luetscher JA Jr, Deming QB, Johnson BB, Harvey J, Lew W, Poo LJ (1951) Treatment of nephrosis with pituitary adrenocorticotrophin. J Clin Invest 12:1530–1541
35. Metcoff J, Rance CP, Kelsey WM, Nakasone N, Janeway CA (1952) Adrenocorticotrophic hormone (ACTH) therapy of the nephrotic syndrome in children. Pediatrics 10:543–566
36. Rapoport M, McCrory WW, Barbero G, Barnett HL, Forman CW (1951) Effect of corticotropin (ACTH) on children with the nephrotic syndrome. JAMA 147:1101–1106
37. Riley CM (1952) Corticotropin and cortisone in management of the nephrotic syndrome in children. JAMA 150:1288–1291
38. Danowski TS, Mateer FM, Puntereri AJ (1959) ACTH or adrenocortical steroid therapy of proteinuria in adolescents and in adults. Am J Med Sci 237:545–558
39. Lange K, Slobody L, Strang R (1953) Treatment of nephrotic syndrome with interrupted ACTH or oral cortisone therapy. Proc Soc Exp Biol Med 82:315–317
40. Merrill AJ, Wilson J, Timerlake LF (1954) Continuous therapy of nephrotic syndrome in children with corticotropin gel. Arch Intern Med 94:925–930
41. Hrachovy RA, Frost JD Jr (2003) Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome). J Clin Neurophysiol 20:408–425
42. Philibert D, Cattran D (2008) Remission of proteinuria in primary glomerulonephritis: we know the goal but do we know the price? Nat Clin Pract Nephrol 4:550–559
43. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children (1981) J Pediatr 98:561–564
44. Kramer B, Goldman H, Cason L (1952) The treatment of the nonedematous nephrotic child with ACTH. J Pediatr 41:792–803
45. Lange K, Strang R, Slobody LB, Wenk EJ (1957) The treatment of the nephrotic syndrome with steroids in children and adults. AMA Arch Intern Med 99:760–770
46. Hooft C, Vermassen A, Herpol J (1959) Reversible gluco-amino-phosphaturia in a child with lipoid nephrosis. Helv Paediatr Acta 14:1–12
47. Lieberman KV, Ettinger L, Picarelli C (2014) Adrenocorticotropic hormone for steroid-resistant and oral steroid-intolerant children with minimal change nephrotic syndrome. J Clin Pediatr Nephrol 2:2
48. Gong R (2012) The renaissance of corticotropin therapy in proteinuric nephropathies. Nat Rev Nephrol 8:122–128
49. Gong R (2014) Leveraging melanocortin pathways to treat glomerular diseases. Adv Chronic Kidney Dis 21:134–151
50. Montero-Melendez T (2015) ACTH: the forgotten therapy. Sem Immunol 27:216–226
51. Gong R, Dworkin LD (2011) Adrenocorticotropin (ACTH) gel suppresses renal tubulointerstitial inflammation and injury by direct stimulation of the melanocortin 1 receptor (MC1R). J Am Soc Nephrol 22(Suppl):136A
52. Lindskog A, Ebefors K, Johansson ME, Stefansson B, Granqvist A, Arnadottir M, Berg AL, Nystrom J, Haraldsson B (2010) Melanocortin 1 receptor agonists reduce proteinuria. J Am Soc Nephrol 21:1290–1298