High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece

European Child and Adolescent Psychiatry

Volumn 27, Issue 1, 2018, Pages 79-88

  Daraki, Vasiliki ^a,b   Roumeliotaki, Theano ^a   Koutra, Katerina ^a   Chalkiadaki, Georgia ^a   Katrinaki, Marianna ^b   Kyriklaki, Andriani ^a   Kampouri, Mariza ^a   Margetaki, Katerina ^a   Vafeiadi, Marina ^a   Papavasiliou, Stathis ^b   Kogevinas, Manolis ^c,d   Chatzi, Leda ^a,e,f  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^c CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

25 hydroxyvitamin D; ADHD; Behavior problems; Cognition; Pregnancy; Preschool children

Indexed keywords

25 HYDROXYVITAMIN D; VITAMIN D;

ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DEFICIT HYPERACTIVITY DISORDER TEST; BEHAVIOR DISORDER; CHILD; COGNITION; COHORT ANALYSIS; FEMALE; FIRST TRIMESTER PREGNANCY; GREECE; HUMAN; HYPERACTIVITY; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MCCARTHY SCALES OF CHILDREN'S ABILITIES; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PRENATAL PERIOD; PRESCHOOL CHILD; PROSPECTIVE STUDY; PROTECTION; SEX DIFFERENCE; STRENGTHS AND DIFFICULTIES QUESTIONNAIRE; VITAMIN BLOOD LEVEL; ADULT; ANIMAL; BRAIN; MOTHER; PATHOPHYSIOLOGY; PREGNANCY; PSYCHOLOGY;

ADULT; ANIMALS; BRAIN; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GREECE; HUMANS; MALE; MOTHERS; PREGNANCY; PROSPECTIVE STUDIES; VITAMIN D;

EID: 85021941372     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-017-1023-x     Document Type: Article

References (38)

1. Kubota T, Miyake K, Hariya N, Mochizuki K (2015) Understanding the epigenetics of neurodevelopmental disorders and DOHaD. J Dev Orig Health Dis 6(2):96–104. doi:10.1017/S2040174415000057
2. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281. doi:10.1056/NEJMra070553
3. Urrutia RP, Thorp JM (2012) Vitamin D in pregnancy: current concepts. Curr Opin Obstet Gynecol 24(2):57–64. doi:10.1097/GCO.0b013e3283505ab3
4. Hamilton SA, McNeil R, Hollis BW, Davis DJ, Winkler J, Cook C, Warner G, Bivens B, McShane P, Wagner CL (2010) Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32°N. Int J Endocrinol 2010:917428. doi:10.1155/2010/917428
5. Karras SN, Anagnostis P, Annweiler C, Naughton DP, Petroczi A, Bili E, Harizopoulou V, Tarlatzis BC, Persinaki A, Papadopoulou F, Goulis DG (2014) Maternal vitamin D status during pregnancy: the Mediterranean reality. Eur J Clin Nutr 68(8):864–869. doi:10.1038/ejcn.2014.80
6. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’Beirne M, Rabi DM (2013) Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 346:f1169. doi:10.1136/bmj.f1169
7. Paterson CR, Ayoub D (2015) Congenital rickets due to vitamin D deficiency in the mothers. Clin Nutr 34(5):793–798. doi:10.1016/j.clnu.2014.12.006
8. Camadoo L, Tibbott R, Isaza F (2007) Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions. Nutr J 6:23. doi:10.1186/1475-2891-6-23
9. Morales E, Romieu I, Guerra S, Ballester F, Rebagliato M, Vioque J, Tardon A, Rodriguez Delhi C, Arranz L, Torrent M, Espada M, Basterrechea M, Sunyer J (2012) Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology 23(1):64–71. doi:10.1097/EDE.0b013e31823a44d3
10. Sharief S, Jariwala S, Kumar J, Muntner P, Melamed ML (2011) Vitamin D levels and food and environmental allergies in the United States: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol 127(5):1195–1202. doi:10.1016/j.jaci.2011.01.017
11. Groves NJ, McGrath JJ, Burne TH (2014) Vitamin D as a neurosteroid affecting the developing and adult brain. Annu Rev Nutr 34:117–141. doi:10.1146/annurev-nutr-071813-105557
12. Morales E, Guxens M, Llop S, Rodriguez-Bernal CL, Tardon A, Riano I, Ibarluzea J, Lertxundi N, Espada M, Rodriguez A, Sunyer J (2012) Circulating 25-hydroxyvitamin D3 in pregnancy and infant neuropsychological development. Pediatrics 130(4):e913–e920. doi:10.1542/peds.2011-3289
13. Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH (2012) Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics 129(3):485–493. doi:10.1542/peds.2011-2644
14. Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62(1):68–77. doi:10.1038/sj.ejcn.1602680
15. Keim SA, Bodnar LM, Klebanoff MA (2014) Maternal and cord blood 25(OH)-vitamin D concentrations in relation to child development and behaviour. Paediatr Perinat Epidemiol 28(5):434–444. doi:10.1111/ppe.12135
16. Strom M, Halldorsson TI, Hansen S, Granstrom C, Maslova E, Petersen SB, Cohen AS, Olsen SF (2014) Vitamin D measured in maternal serum and offspring neurodevelopmental outcomes: a prospective study with long-term follow-up. Ann Nutr Metab 64(3–4):254–261. doi:10.1159/000365030
17. Tylavsky FA, Kocak M, Murphy LE, Graff JC, Palmer FB, Volgyi E, Diaz-Thomas AM, Ferry RJ (2015) Gestational vitamin 25(OH)D status as a risk factor for receptive language development: a 24-month, longitudinal, observational study. Nutrients 7(12):9918–9930. doi:10.3390/nu7125499
18. Zhu P, Tong SL, Hao JH, Tao RX, Huang K, Hu WB, Zhou QF, Jiang XM, Tao FB (2015) Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers. J Nutr 145(6):1232–1238. doi:10.3945/jn.114.208801
19. Gould JF, Anderson AJ, Yelland LN, Smithers LG, Skeaff CM, Zhou SJ, Gibson RA, Makrides M (2016) Association of cord blood vitamin D with early childhood growth and neurodevelopment. J Paediatr Child Health. doi:10.1111/jpc.13308
20. Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Hart PH, Kusel MM (2013) Maternal vitamin D levels and the autism phenotype among offspring. J Autism Dev Disord 43(7):1495–1504. doi:10.1007/s10803-012-1676-8
21. Morales E, Julvez J, Torrent M, Ballester F, Rodriguez-Bernal CL, Andiarena A, Vegas O, Castilla AM, Rodriguez-Dehli C, Tardon A, Sunyer J (2015) Vitamin D in pregnancy and attention deficit hyperactivity disorder-like symptoms in childhood. Epidemiology 26(4):458–465. doi:10.1097/EDE.0000000000000292
22. Gustafsson P, Rylander L, Lindh CH, Jonsson BA, Ode A, Olofsson P, Ivarsson SA, Rignell-Hydbom A, Haglund N, Kallen K (2015) Vitamin D status at birth and future risk of attention deficit/hyperactivity disorder (ADHD). PLoS ONE 10(10):e0140164. doi:10.1371/journal.pone.0140164
23. Chatzi L, Plana E, Daraki V, Karakosta P, Alegkakis D, Tsatsanis C, Kafatos A, Koutis A, Kogevinas M (2009) Metabolic syndrome in early pregnancy and risk of preterm birth. Am J Epidemiol 170(7):829–836. doi:10.1093/aje/kwp211
24. Katrinaki M, Kampa M, Margioris A, Castanas E, Malliaraki N (2016) Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values. Hormones (Athens) 15(2):205–223. doi:10.14310/horm.2002.1674
25. Goodman R (1997) The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 38(5):581–586
26. Mpipou-Nakou I, Stogiannidou A, Kisseoglou G (2001) Strengths and difficulties of school-age children in the family and school context. Psychologia 8(4):506–525
27. Gilliam JE (1995) Examiners manual for the attention-deficit/hyperactivity disorder test: a method for identifying individuals with ADHD. pro-Ed, Austin
28. Maniadaki K, Kakouros E (2002) Translation and adaptation of the attention deficit hyperactivity disorder test (ADHDT; Giliam, 1995). In: Stalikas A, Triliva S, Roussi P (eds) The psychometric Instruments in Greece. Ellinika Grammata, Athens, pp 102–103
29. McCarthy D (1972) Manual for the McCarthy scales of children’s abilities. Psychological Corp, New York
30. Kampouri M, Kyriklaki A, Roumeliotaki T, Koutra K, Anousaki D, Sarri K, Vassilaki M, Kogevinas M, Chatzi L (2017) Patterns of early-life social and environmental exposures and child cognitive development, Rhea birth cohort, Crete, Greece. Child Dev. doi:10.1111/cdev.12782
31. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930. doi:10.1210/jc.2011-0385
32. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96(1):53–58. doi:10.1210/jc.2010-2704
33. Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F (2003) Vitamin D3 and brain development. Neuroscience 118(3):641–653
34. Eyles DW, Burne TH, McGrath JJ (2013) Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 34(1):47–64. doi:10.1016/j.yfrne.2012.07.001
35. O’Loan J, Eyles DW, Kesby J, Ko P, McGrath JJ, Burne TH (2007) Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology 32(3):227–234. doi:10.1016/j.psyneuen.2006.12.006
36. Correale J, Ysrraelit MC, Gaitan MI (2010) Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects. J Immunol 185(8):4948–4958. doi:10.4049/jimmunol.1000588
37. Grandjean P, Landrigan PJ (2006) Developmental neurotoxicity of industrial chemicals. The Lancet 368(9553):2167–2178
38. Bellinger DC (2012) A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children. Environ Health Perspect 120(4):501