Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats

Inflammation

Volumn 40, Issue 5, 2017, Pages 1773-1781

  Dela Justina, Vanessa ^a   Gonçalves, Jéssica S ^a   de Freitas, Raiany Alves ^a   Fonseca, Adriany Dias ^a   Volpato, Gustavo T ^a   Tostes, Rita C ^b   Carneiro, Fernando S ^b   Lima, Victor Vitorino ^a   Giachini, Fernanda R ^a  

^a FEDERAL UNIVERSITY OF MATO GROSSO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

glycosylation; IL 6; O GlcNAc; TNF

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; N ACETYLGLUCOSAMINE; O LINKED N ACETYLGLUCOSAMINE; STREPTOZOCIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FETUS; FETUS WEIGHT; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; HYPERGLYCEMIA; IMMUNOPRECIPITATION; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; PLACENTA DISORDER; PLACENTA TISSUE; PLACENTA WEIGHT; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; METABOLISM; PATHOPHYSIOLOGY; PLACENTA; PREGNANCY; PREGNANCY COMPLICATION; PROTEIN PROCESSING;

ACETYLGLUCOSAMINE; ANIMALS; CYTOKINES; FEMALE; FETAL GROWTH RETARDATION; HYPERGLYCEMIA; NF-KAPPA B; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS;

EID: 85021931022     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-017-0620-7     Document Type: Article

References (35)

1. Desoye, G., and Hauguel-de Mouzon S. 2007. The human placenta in gestational diabetes mellitus: The insulin and cytokine network. Diabetes Care 30: 120–126.
2. Huynh, Q.K., H. Boddupalli, S.A. Rouw, C.M. Koboldt, T. Hall, C. Sommers, et al. 2000. Characterization of the recombinant IKK1 / IKK2 heterodimer. The Journal of Biological Chemistry 275: 25883–25891.
3. Pantham, P., I.L.M.H. Aye, and T.L. Powell. 2015. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta 36: 709–715.
4. Moreli, J.B., A.M.C. Ruocco, J.M. Vernini, M.V.C. Rudge, and I.M.P. Calderon. 2011. Interleukin 10 and tumor necrosis factor-alpha in pregnancy: Aspects of interest in clinical obstetrics. ISRN Obstetrics and Gynecology 2012: 1–5.
5. Oztas, E., K. Erkenekli, S. Ozler, A. Aktas, and U. Buyukkagn. 2015. First trimester interleukin-6 levels help to predict adverse pregnancy outcomes in both thyroid autoantibody positive and negative patients. Journal of Obstetrics and Gynaecology Research 41: 1700–1707.
6. Vaughan, J.E., and S.W. Walsh. 2012. Activation of NF-kB in placentas of women with preeclampsia. Hypertension in Pregnancy 31: 243–251.
7. Lai, J., Y. Liu, C. Liu, M. Qi, R. Liu, X. Zhu, et al. 2016. Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways. Inflammation 1–12.
8. Yang, W.H., S.Y. Park, H.W. Nam, D.H. Kim, J.G. Kang, E.S. Kang, et al. 2008. NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proceedings of the National Academy of Sciences 105: 17345–17350.
9. Laczy, B., B.G. Hill, K. Wang, A.J. Paterson, C.R. White, D. Xing, et al. 2009. Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system. American Journal of Physiology. Heart and Circulatory Physiology 296: 13–28.
10. Lima, V.V., K. Spitler, H. Choi, R.C. Webb, and R.C. Tostes. 2012. O-GlcNAcylation and oxidation of proteins: Is signalling in the cardiovascular system becoming sweeter? Clinical Science 486: 473–486.
11. Ahmed, S., E.N. Mundh, M. Borgohain, L. Chowdhury, M. Kwatra, N. Bolshette, et al. 2016. Diosmin modulates the NF-kB signal transduction pathways and downregulation of various oxidative stress markers in alloxan-induced diabetic nephropathy. Inflammation 39: 1783–1797.
12. Baudoin, L., and T. Issad. 2014. O-GlcNAcylation and inflammation: A vast territory to explore. Frontiers in Endocrinology 5: 1–8.
13. Agca, C.A., M. Tuzcu, A. Hayirli, and K. Sahin. 2014. Taurine ameliorates neuropathy via regulating NF-kB and Nrf2/HO-1 signaling cascades in diabetic rats. Food and Chemical Toxicology 71: 116–121.
14. Bowie, A., and L.A.J.O. Neill. 2000. Oxidative stress and nuclear factor kappa B activation. Biochemical Pharmacology 59: 13–23.
15. Drougat, L., Olivier-Van Stichelen S., M. Mortuaire, F. Foulquier, A.S. Lacoste, J.C. Michalski, et al. 2012. Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition. Biochimica et Biophysica Acta 1820: 1839–1848.
16. Frank, L.A., M.L. Sutton-McDowall, H.M. Brown, D.L. Russell, R.B. Gilchrist, and J.G. Thompson. 2014. Hyperglycemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of heat shock protein 90. Human Reproduction 29: 1292–1303.
17. Phoomak, C., Kulthida, V., Kanlayanee, S., Wunchana, S., Chaisiri, W., Atit, S., Sopit, W. 2016. Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-κB. Scientific Reports p.1–12.
18. Viatour, P., M. Merville, V. Bours, and A. Chariot. 2005. Phosphorylation of NF-kB and IkB proteins: Implications in cancer and inflammation. Trends in Biochemical Sciences 30: 43–52.
19. Liu, K., A.J. Paterson, E. Chin, and J.E. Kudlow. 2000. Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: Linkage of O-linked GlcNAc to beta cell death. Proceedings of the National Academy of Sciences 97: 2820–2825.
20. Akimoto, Y., H. Kawakami, K. Yamamoto, E. Munetomo, T. Hida, and H. Hirano. 2003. Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats. Investigative Ophthalmology & Visual Science 44: 3802–3809.
21. Marshall, S., O. Nadeau, and K. Yamasaki. 2004. Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: Differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine, and ATP levels. The Journal of Biological Chemistry 279: 35313–35319.
22. Yki-Järvinen, H., A. Virkamäki, M.C. Daniels, D. McClain, and W.K. Gottschalk. 1998. Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo. Metabolism 47: 449–455.
23. Vermeulen, L., D.W. Gerte, V.D. Petra, V.B. Wim, and H. Guy. 2003. Transcriptional activation of the NF-k B p65 subunit by mitogen- and stress-activated protein kinase-1. EMBO Journal 22: 1313–1324.
24. Chen, L.F., W. Fischle, E. Verdin, and W.C. Greene. 2001. Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293: 1653–1657.
25. James, L.R., et al. Flux through the hexosamine pathway is a determinant of nuclear fator kB-dependent promoter activation. Diabetes 51: 146–1156.
26. Hu, P., S. Shimoji, and G.W. Hart. 2010. Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. FEBS Letters 584: 2526–2538.
27. Comer, F.I., and W.H. Gerald. 2000. O-Glycosylation of nuclear and cytosolic proteins. The Journal of Biological Chemistry 275: 29179–29182.
28. Gao, Y., W. Lance, I.C. Frank, J.P. Glendon, and W.H. Gerald. 2001. Dynamic O-glycosylation of nuclear and cytosolic proteins: Cloning and characterization of a neutral, cytosolic β-N-acetylglucosaminidase from human brain. Journal of Biological Chemistry 276: 9838–9845.
29. Ramakrishnan, P., M.C. Peter, E.M. Daniel, C.P. Eric, C.H. Linda, and B. David. 2013. Activation of the transcriptional function of the NF-kappaB protein c-Rel by O-GlcNAc glycosylation. Science Signaling. Immunology 6: 1–13.
30. Kirwan, J.P., S.H. Mouzon, J. Lepercq, J. Challier, L. Huston-presley, J.E. Friedman, et al. 2002. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 51: 2207–2213.
31. Hauguel-de Mouzon, S., and M. Guerre-Millo. 2006. The placenta cytokine network and inflammatory signals. Placenta 27: 794–798.
32. Higgins, M., and F. Mc Auliffe. 2010. A review of maternal and fetal growth factors in diabetic pregnancy. Current Diabetes Reviews 6: 116–125.
33. Damasceno, D.C., Y.K. Sinzato, A. Bueno, A.O. Netto, B. Dallaqua, F.Q. Gallego, et al. 2013. Mild diabetes models and their maternal-fetal repercussions. Journal of Diabetes Research 2013: 1–9.
34. Sinzato, Y.K., G.T. Volpato, I.L. Iessi, A. Bueno, I. De Mattos, P. Calderon, et al. 2012. Neonatally induced mild diabetes in rats and its effect on maternal, placental and fetal parameters. Experimental Diabetes Research 2012: 1–7.
35. Zhou, J., X. Ni, X. Huang, J. Yao, Q. He, K. Wang, et al. 2016. Potential role of hyperglycemia in fetoplacental endothelial dysfunction in gestational diabetes mellitus. Cellular Physiology and Biochemistry 39: 1317–1328.