Angiotensin-converting enzyme affects the presentation of MHC class II antigens

Laboratory Investigation

Volumn 97, Issue 7, 2017, Pages 764-771

  Zhao, Tuantuan ^a,b   Bernstein, Kenneth E ^b   Fang, Jianmin ^a   Shen, Xiao Z ^c  

^a TONGJI UNIVERSITY   (China)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD69 ANTIGEN; CD86 ANTIGEN; DIPEPTIDYL CARBOXYPEPTIDASE; INTERLEUKIN 17; INTERLEUKIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HLA ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CATALYSIS; CD4+ T LYMPHOCYTE; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOSOME; ENZYME INHIBITION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PINOCYTOSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; UPREGULATION; ANIMAL; CELL CULTURE; CELL LINE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MICE, KNOCKOUT; OVALBUMIN; PEPTIDYL-DIPEPTIDASE A;

EID: 85021796057     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2017.32     Document Type: Article

References (18)

1. Alfonso C, Han JO, Williams GS, et al. The impact of H2-DM on humoral immune responses. J Immunol 2001;167:6348-6355.
2. Bernstein KE, Ong FS, Blackwell WL, et al. A modern understanding of the traditional and nontraditional biological functions of angiotensinconverting enzyme. Pharmacol Rev 2013;65:1-46.
3. Busch R, Rinderknecht CH, Roh S, et al. Achieving stability through editing and chaperoning: Regulation of MHC class II peptide binding and expression. Immunol Rev 2005;207:242-260.
4. Cole J, Ertoy D, Lin H, et al. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzymedeficient mice. J Clin Invest 2000;106:1391-1398.
5. Danilov SM, Sadovnikova E, Scharenborg N, et al. Angiotensinconverting enzyme (CD143) is abundantly expressed by dendritic cells and discriminates human monocyte-derived dendritic cells from acute myeloid leukemia-derived dendritic cells. Exp Hematol 2003;31: 1301-1309.
6. Esther Jr CR, Howard TE, Marino EM, et al. Mice lacking angiotensinconverting enzyme have low blood pressure, renal pathology, reduced male fertility. Lab Invest 1996;74:953-965.
7. Harmer D, Gilbert M, Borman R, et al. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett 2002;532:107-110.
8. Kool M, Soullie T, van Nimwegen M, et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 2008;205:869-882.
9. Neefjes J, Jongsma ML, Paul P, et al. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol 2011;11:823-836.
10. Roche PA, Furuta K. The ins and outs of MHC class II-mediated antigen processing and presentation. Nat Rev Immunol 2015;15:203-216.
11. Saijonmaa O, Nyman T, Fyhrquist F. Atorvastatin inhibits angiotensinconverting enzyme induction in differentiating human macrophages. Am J Physiol Heart Circ Physiol 2007;292:H1917-H1921.
12. Shen XZ, Billet S, Lin C, et al. The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat Immunol 2011;12:1078-1085.
13. Shen XZ, Li P, Weiss D, et al. Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol 2007;170:2122-2134.
14. Cresswell P. Invariant chain structure and MHC class II function. Cell 1996;84:505-507.
15. Shen XZ, Lukacher AE, Billet S, et al. Expression of angiotensinconverting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors. J Biol Chem 2008;283:9957-9965.
16. Singh R, Cresswell P. Defective cross-presentation of viral antigens in GILT-free mice. Science 2010;328:1394-1398.
17. Shorr AF, Torrington KG, Parker JM. Serum angiotensin converting enzyme does not correlate with radiographic stage at initial diagnosis of sarcoidosis. Respir Med 1997;91:399-401.
18. Kahkouee S, Samadi K, Alai A, et al. Serum ACE level in sarcoidosis patients with typical and atypical HRCT manifestation. Pol J Radiol 2016;81:458-461.