Low Accuracy of Positive qSOFA Criteria for Predicting 28-Day Mortality in Critically Ill Septic Patients During the Early Period After Emergency Department Presentation

Annals of Emergency Medicine

Volumn 71, Issue 1, 2018, Pages 1-9.e2

  Hwang, Sung Yeon ^a,b   Jo, Ik Joon ^a   Lee, Se Uk ^a   Lee, Tae Rim ^a,b   Yoon, Hee ^a,b   Cha, Won Chul ^a   Sim, Min Seob ^a   Shin, Tae Gun ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BREATHING RATE; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIAGNOSTIC ACCURACY; EMERGENCY WARD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; REGISTER; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SYSTOLIC BLOOD PRESSURE; THINKING IMPAIRMENT; ADOLESCENT; CRITICAL ILLNESS; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; ORGAN DYSFUNCTION SCORE; RECEIVER OPERATING CHARACTERISTIC; SOUTH KOREA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CRITICAL ILLNESS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; ORGAN DYSFUNCTION SCORES; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; SEPSIS; YOUNG ADULT;

EID: 85021377953     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2017.05.022     Document Type: Article

References (29)

1. Angus, D.C., Linde-Zwirble, W.T., Lidicker, J., et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001), 1303–1310.
2. Bone, R.C., Balk, R.A., Cerra, F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101 (1992), 1644–1655.
3. Singer, M., Deutschman, C.S., Seymour, C.W., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315 (2016), 801–810.
4. Seymour, C.W., Liu, V.X., Iwashyna, T.J., et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315 (2016), 762–774.
5. Shin, T.G., Jo, I.J., Hwang, S.Y., et al. Comprehensive interpretation of central venous oxygen saturation and blood lactate levels during resuscitation of patients with severe sepsis and septic shock in the emergency department. Shock 45 (2016), 4–9.
6. Joo, Y.M., Chae, M.K., Hwang, S.Y., et al. Impact of timely antibiotic administration on outcomes in patients with severe sepsis and septic shock in the emergency department. Clin Exp Emerg Med 1 (2014), 35–40.
7. Hwang, S.Y., Shin, T.G., Jo, I.J., et al. Association between hemodynamic presentation and outcome in sepsis patients. Shock 42 (2014), 205–210.
8. Jeon, K., Shin, T.G., Sim, M.S., et al. Improvements in compliance with resuscitation bundles and achievement of end points after an educational program on the management of severe sepsis and septic shock. Shock 37 (2012), 463–467.
9. Shin, T.G., Jo, I.J., Choi, D.J., et al. The adverse effect of emergency department crowding on compliance with the resuscitation bundle in the management of severe sepsis and septic shock. Crit Care, 17, 2013, R224.
10. Kang, M.J., Shin, T.G., Jo, I.J., et al. Factors influencing compliance with early resuscitation bundle in the management of severe sepsis and septic shock. Shock 38 (2012), 474–479.
11. Levy, M.M., Fink, M.P., Marshall, J.C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31 (2003), 1250–1256.
12. Kaji, A.H., Schriger, D., Green, S., Looking through the retrospectoscope: reducing bias in emergency medicine chart review studies. Ann Emerg Med 64 (2014), 292–298.
13. Vincent, J.L., Moreno, R., Takala, J., et al., on behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 22 (1996), 707–710.
14. Knaus, W.A., Draper, E.A., Wagner, D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 13 (1985), 818–829.
15. Dellinger, R.P., Levy, M.M., Rhodes, A., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41 (2013), 580–637.
16. Bossuyt, P.M., Cohen, J.F., Gatsonis, C.A., et al. STARD 2015: updated reporting guidelines for all diagnostic accuracy studies. Ann Transl Med, 4, 2016, 85.
17. Singer, A.J., Ng, J., Thode, H.C. Jr., et al. Quick SOFA scores predict mortality in adult emergency department patients with and without suspected infection. Ann Emerg Med 69 (2017), 475–479.
18. Freund, Y., Lemachatti, N., Krastinova, E., et al. Prognostic accuracy of Sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department. JAMA 317 (2017), 301–308.
19. Williams, J.M., Greenslade, J.H., McKenzie, J.V., et al. SIRS, qSOFA and organ dysfunction: insights from a prospective database of emergency department patients with infection. Chest 151 (2017), 586–596.
20. Wang, J.Y., Chen, Y.X., Guo, S.B., et al. Predictive performance of quick Sepsis-related Organ Failure Assessment for mortality and ICU admission in patients with infection at the ED. Am J Emerg Med 34 (2016), 1788–1793.
21. Churpek, M.M., Snyder, A., Han, X., et al. qSOFA, SIRS, and early warning scores for detecting clinical deterioration in infected patients outside the ICU. Am J Respir Crit Care Med 195 (2017), 906–911.
22. April, M.D., Aguirre, J., Tannenbaum, L.I., et al. Sepsis clinical criteria in emergency department patients admitted to an intensive care unit: an external validation study of quick Sequential Organ Failure Assessment. J Emerg Med 52 (2017), 622–631.
23. Dorsett, M., Kroll, M., Smith, C.S., et al. qSOFA has poor sensitivity for prehospital identification of severe sepsis and septic shock. Prehosp Emerg Care, 2017 http://dx.doi.org/10.1080/10903127.2016.1274348.
24. Raith, E.P., Udy, A.A., Bailey, M., et al. Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA 317 (2017), 290–300.
25. Chen, Y.X., Wang, J.Y., Guo, S.B., Use of CRB-65 and quick Sepsis-related Organ Failure Assessment to predict site of care and mortality in pneumonia patients in the emergency department: a retrospective study. Crit Care, 20, 2016, 167.
26. Vincent, J.-L., Pereira, A.J., Gleeson, J., et al. Early management of sepsis. Clin Exp Emerg Med 1 (2014), 3–7.
27. Puskarich, M.A., Trzeciak, S., Shapiro, N.I., et al. Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation 82 (2011), 1289–1293.
28. Ho, K.M., Lan, N.S., Combining quick Sequential Organ Failure Assessment with plasma lactate concentration is comparable to standard Sequential Organ Failure Assessment score in predicting mortality of patients with and without suspected infection. J Crit Care 38 (2016), 1–5.
29. Leligdowicz, A., Dodek, P.M., Norena, M., et al. Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med 189 (2014), 1204–1213.