Urinary albumin and 8-oxo-7,8-dihydroguanosine as markers of mortality and cardiovascular disease during 19 years after diagnosis of type 2 diabetes – A comparative study of two markers to identify high risk patients

Redox Biology

Volumn 13, Issue , 2017, Pages 363-369

  Broedbaek, Kasper ^a,b   Køster Rasmussen, Rasmus ^c   Siersma, Volkert ^c   Persson, Frederik ^d   Poulsen, Henrik E ^a,b,e   de Fine Olivarius, Niels ^c  

^a Rigshospitalet   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d STENO DIABETES CENTER   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXO 7,8 DIHYDROGUANOSINE; ALBUMIN; GUANOSINE DERIVATIVE; INSULIN; ORAL ANTIDIABETIC AGENT; UNCLASSIFIED DRUG; 8-HYDROXYGUANOSINE; BIOLOGICAL MARKER; GUANOSINE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETIC PATIENT; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; FEMALE; FUNCTION TEST; HIGH RISK PATIENT; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; REFERENCE VALUE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SURVIVAL TIME; URINALYSIS; ALBUMINURIA; ANALOGS AND DERIVATIVES; COMPLICATION; MIDDLE AGED; URINE;

AGED; ALBUMINURIA; BIOMARKERS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; FEMALE; GUANOSINE; HUMANS; MALE; MIDDLE AGED;

EID: 85021344276     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2017.06.005     Document Type: Article

References (34)

1. Parving, H.H., Persson, F., Rossing, P., Microalbuminuria: a parameter that has changed diabetes care. Diabetes Res. Clin. Pract. 107 (2015), 1–8.
2. Weir, M.R., Microalbuminuria in type 2 diabetics: an important, overlooked cardiovascular risk factor. J. Clin. Hypertens. 6 (2004), 134–141.
3. Guo, L., Cheng, Y., Wang, X., et al. Association between microalbuminuria and cardiovascular disease in type 2 diabetes mellitus of the Beijing Han nationality. Acta Diabetol. 49:Suppl 1 (2012), S65–S71.
4. Jensen, J.S., Borch-Johnsen, K., Jensen, G., Feldt-Rasmussen, B., Microalbuminuria reflects a generalized transvascular albumin leakiness in clinically healthy subjects. Clin. Sci. 88 (1995), 629–633.
5. Jensen, J.S., Feldt-Rasmussen, B., Borch-Johnsen, K., Jensen, K.S., Nordestgaard, B.G., Increased transvascular lipoprotein transport in diabetes: association with albuminuria and systolic hypertension. J. Clin. Endocrinol. Metab. 90 (2005), 4441–4445.
6. Satchell, S.C., Tooke, J.E., What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?. Diabetologia 51 (2008), 714–725.
7. Kalaitzidis, R., Bakris, G., Pathogenesis and treatment of microalbuminuria in patients with diabetes: the road ahead. J. Clin. Hypertens. 11 (2009), 636–643.
8. Svendstrup, M., Christiansen, M.S., Magid, E., Hommel, E., Feldt-Rasmussen, B., Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up. J. Diabetes Complicat. 27 (2013), 570–575.
9. Zurbig, P., Jerums, G., Hovind, P., et al. Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes 61 (2012), 3304–3313.
10. Broedbaek, K., Siersma, V., Henriksen, T., et al. Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study. Diabetes Care 36 (2013), 669–676.
11. Broedbaek, K., Siersma, V., Henriksen, T., et al. Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care 34 (2011), 2594–2596.
12. Sies, H., Oxidative stress: a concept in redox biology and medicine. Redox Biol. 4 (2015), 180–183.
13. Brownlee, M., The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54 (2005), 1615–1625.
14. Olivarius, N.F., Beck-Nielsen, H., Andreasen, A.H., Horder, M., Pedersen, P.A., Randomised controlled trial of structured personal care of type 2 diabetes mellitus. Br. Med. J. 323 (2001), 970–975.
15. Mogensen, C.E., Microalbuminuria and kidney function. Notes on methods, interpretation, and classification. Clarke, W.L., Larner, J., Pohl, S., (eds.) Methods in Clinical Research. Vol II: Clinical Methods, 1986, Wiley, New York.
16. Henriksen, T., Hillestrom, P.R., Poulsen, H.E., Weimann, A., Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2'-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radic. Biol. Med. 47 (2009), 629–635.
17. Pedersen, C.B., The Danish civil registration system. Scand. J. Public Health 39 (2011), 22–25.
18. Lynge, E., Sandegaard, J.L., Rebolj, M., The Danish national patient register. Scand. J. Public Health 39 (2011), 30–33.
19. Helweg-Larsen, K., The Danish register of causes of death. Scand. J. Public Health 39 (2011), 26–29.
20. Parving, H.H., Lehnert, H., Brochner-Mortensen, J., Gomis, R., Andersen, S., Arner, P., The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N. Engl. J. Med. 345 (2001), 870–878.
21. Savage, S., Estacio, R.O., Jeffers, B., Schrier, R.W., Urinary albumin excretion as a predictor of diabetic retinopathy, neuropathy, and cardiovascular disease in NIDDM. Diabetes Care 19 (1996), 1243–1248.
22. O'Hare, A.M., Hailpern, S.M., Pavkov, M.E., et al. Prognostic implications of the urinary albumin to creatinine ratio in veterans of different ages with diabetes. Arch. Intern. Med. 170 (2010), 930–936.
23. Viana, L.V., Gross, J.L., Camargo, J.L., Zelmanovitz, T., da Costa Rocha, E.P., Azevedo, M.J., Prediction of cardiovascular events, diabetic nephropathy, and mortality by albumin concentration in a spot urine sample in patients with type 2 diabetes. J. Diabetes Complicat. 26 (2012), 407–412.
24. Hillege, H.L., Fidler, V., Diercks, G.F., et al. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 106 (2002), 1777–1782.
25. Wachtell, K., Ibsen, H., Olsen, M.H., et al. Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. Ann. Intern. Med. 139 (2003), 901–906.
26. Hillege, H.L., Janssen, W.M., Bak, A.A., et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J. Intern. Med. 249 (2001), 519–526.
27. Mogensen, C.E., Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N. Engl. J. Med. 310 (1984), 356–360.
28. Gall, M.A., Borch-Johnsen, K., Hougaard, P., Nielsen, F.S., Parving, H.H., Albuminuria and poor glycemic control predict mortality in NIDDM. Diabetes 44 (1995), 1303–1309.
29. Dinneen, S.F., Gerstein, H.C., The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature. Arch. Intern. Med. 157 (1997), 1413–1418.
30. Mattock, M.B., Morrish, N.J., Viberti, G., Keen, H., Fitzgerald, A.P., Jackson, G., Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 41 (1992), 736–741.
31. Neil, A., Hawkins, M., Potok, M., Thorogood, M., Cohen, D., Mann, J., A prospective population-based study of microalbuminuria as a predictor of mortality in NIDDM. Diabetes Care 16 (1993), 996–1003.
32. Rutter, M.K., Wahid, S.T., McComb, J.M., Marshall, S.M., Significance of silent ischemia and microalbuminuria in predicting coronary events in asymptomatic patients with type 2 diabetes. J. Am. Coll. Cardiol. 40 (2002), 56–61.
33. Monnier, L., Mas, E., Ginet, C., et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. J. Am. Med. Assoc. 295 (2006), 1681–1687.
34. Ceriello, A., Esposito, K., Piconi, L., et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 57 (2008), 1349–1354.