Increased neural response to social rejection in major depression

Depression and Anxiety

Volumn 34, Issue 11, 2017, Pages 1049-1056

  Kumar, Poornima ^a,b   Waiter, Gordon D ^c   Dubois, Magda ^a   Milders, Maarten ^d   Reid, Ian ^e   Steele, J Douglas ^f  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e UNIVERSITY OF ABERDEEN   (United Kingdom)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

amygdala; cyberball; insula; self esteem; social exclusion

Indexed keywords

ADULT; AMYGDALA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYBERBALL PASSING GAME; FEMALE; GAME; HUMAN; HYPERACTIVITY; INSULA; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SELF ESTEEM; SOCIAL EXCLUSION; SOCIAL INTERACTION; SOCIAL REJECTION; VENTROLATERAL PREFRONTAL CORTEX; ANHEDONIA; ATTITUDE; BRAIN CORTEX; BRAIN MAPPING; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGY; SOCIAL DISTANCE;

ADULT; AMYGDALA; ANHEDONIA; BRAIN MAPPING; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; REJECTION (PSYCHOLOGY); SOCIAL DISTANCE;

EID: 85021266224     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22665     Document Type: Article

References (42)

1. Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.
2. Cacioppo, S., Frum, C., Asp, E., Weiss, R. M., Lewis, J. W., & Cacioppo, J. T. (2013). A quantitative meta-analysis of functional imaging studies of social rejection. Scientific Reports, 3, srep02027.
3. Cheng, H., & Furnham, A. (2003). Personality, self-esteem, and demographic predictions of happiness and depression. Personality and Individual Differences, 34(6), 921–942.
4. Cochran, D., Fallon, D., Hill, M., & Frazier, J. A. (2013). The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings. Harvard Review of Psychiatry, 21(5), 219–247.
5. Ehnvall, A., Mitchell, P. B., Hadzi-Pavlovic, D., Parker, G., Frankland, A., Loo, C.,.. Perich, T. (2014). Rejection sensitivity and pain in bipolar versus unipolar depression. Bipolar Disorders, 16(2), 190–198.
6. Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302(5643), 290–292.
7. Gradin, V. B., Waiter, G., Kumar, P., Stickle, C., Milders, M., Matthews, K.,.. Steele, J. D. (2012). Abnormal neural responses to social exclusion in schizophrenia. PloS One, 7(8), e42608.
8. Hamilton, M. (1980). Rating depressive patients. Journal of Clinical Psychiatry, 41, 21–24.
9. Hammen, C. (2005). Stress and depression. Annual Review of Clinical Psychology, 1, 293–319.
10. Harmer, C. J., & Cowen, P. J. (2013). “It”s the way that you look at it’–a cognitive neuropsychological account of SSRI action in depression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 368(1615), 20120407, 1–8.
11. Hirschfeld, R. M. A., Montgomery, S. A., Keller, M. B., Kasper, S., Schatzberg, A. F., Möller, H.-J., … Bourgeois, M. (2000). Social functioning in depression: A review. Journal of Clinical Psychiatry, 61(4), 268–275.
12. Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Walker, S. J.,.. Zubieta, J. (2015). It still hurts: Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. Molecular Psychiatry, 20(2), 193–200.
13. Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Wang, H.,.. Zubieta, J. (2013). Response of the μ-opioid system to social rejection and acceptance. Molecular Psychiatry, 18(11), 1211–1217.
14. Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002). Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage, 17, 825–841.
15. Jobst, A., Sabass, L., Palagyi, A., Bauriedl-schmidt, C., Christine, M., Sarubin, N.,.. Padberg, F. (2017). Effects of social exclusion on emotions and oxytocin and cortisol levels in patients with chronic depression. Journal of Psychiatric Research, 60(2015), 170–177.
16. Kashdan, T. B., Dewall, C. N., Masten, C. L., Jr., R. S. P., Powell, C., Combs, D.,.. Farmer, A. S. (2014). Who is most vulnerable to social rejection? The toxic combination of low self-esteem and lack of negative emotion differentiation on neural responses to rejection. PloS One, 9(3), e90651.
17. Kawamoto, T., Ura, M., Nittono, H., & Osipowicz, K. (2015). Intrapersonal and interpersonal processes of social exclusion. Frontiers in Neuroscience, 9(62), 1–11.
18. Keedwell, P., Drapier, D., Surguladze, S., Giampietro, V., Brammer, M., & Phillips, M. (2009). Neural markers of symptomatic improvement during antidepressant therapy in severe depression: Subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score. Journal of Psychopharmacology, 23(7), 775–788.
19. Kupferberg, A., Bicks, L., & Hasler, G. (2016). Social functioning in major depressive disorder. Neuroscience and Biobehavioral Reviews, 69, 313–332.
20. Lau, J. Y. F., Guyer, a. E., Tone, E. B., Jenness, J., Parrish, J. M., Pine, D. S., & Nelson, E. E. (2012). Neural responses to peer rejection in anxious adolescents: Contributions from the amygdala-hippocampal complex. International Journal of Behavioral Development, 36(1), 36–44.
21. Leary, M. R., Terdal, S. K., Tambor, E. S., & Downs, D. L. (1995). Self-esteem as an interpersonal monitor: The sociometer hypothesis. Journal of Personality and Social Psychology, 68(3), 518–530.
22. Liu, R. T., Kraines, M. a, Massing-Schaffer, M., & Alloy, L. B. (2014). Rejection sensitivity and depression: Mediation by stress generation. Psychiatry, 77(1), 86–97.
23. Masten, C. L., Eisenberger, N. I., Borofsky, L. A., McNealy, K., Pfeifer, J. H., & Dapretto, M. (2011). Subgenual anterior cingulate responses to peer rejection: A marker of adolescents’ risk for depression. Development and Psychopathology, 23(1), 283–292.
24. Masten, C. L., Eisenberger, N. I., Borofsky, L. A, Pfeifer, J. H., McNealy, K., Mazziotta, J. C., & Dapretto, M. (2009). Neural correlates of social exclusion during adolescence: Understanding the distress of peer rejection. Social Cognitive and Affective Neuroscience, 4(2), 143–157.
25. Nelson, H. E., & Willison, J. (1991). The national adult reading test (NART). Windsor: NFER-Nelson.
26. Nolan, S. A, Flynn, C., & Garber, J. (2003). Prospective relations between rejection and depression in young adolescents. Journal of Personality and Social Psychology, 85(4), 745–755.
27. Onoda, K., Okamoto, Y., Nakashima, K., Nittono, H., Yoshimura, S., Yamawaki, S.,.. Ura, M. (2010). Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism. Social Cognitive and Affective Neuroscience, 5(4), 385–391.
28. Premkumar, P. (2012). Are you being rejected or excluded? Insights from neuroimaging studies using different rejection paradigms. Clinical Psychopharmacology and Neuroscience, 10(3), 144–154.
29. Rhebergen, D., Beekman, A. T. F., de Graaf, R., Nolen, W. A., Spijker, J., Hoogendijk, W. J., & Penninx, B. W. J. H. (2010). Trajectories of recovery of social and physical functioning in major depression, dysthymic disorder and double depression: A 3-year follow-up. Journal of Affective Disorders, 124(1–2), 148–156.
30. Rizvi, S. J., Cyriac, A., Grima, E., Tan, M., Lin, P., Gallaugher, L. A.,.. Kennedy, S. H. (2015). Depression and employment status in primary and tertiary care settings. Canadian Journal Psychiatry, 60(1), 14–22.
31. Rosenberg, M. (1965). Society and the adolescent self-image. Princeton, NJ: Princeton University Press.
32. Sankoh, A. J., Huque, M. F., & Dubey, S. D. (1997). Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Statistics in Medicine, 16, 2529–2542.
33. Sebastian, C. L., Tan, G. C. Y., Roiser, J. P., Viding, E., Dumontheil, I., & Blakemore, S. J. (2011). Developmental influences on the neural bases of responses to social rejection: Implications of social neuroscience for education. NeuroImage, 57(3), 686–694.
34. Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H.,.. Greicius, M. D. (2007). Dissociable intrinsic connectivity networks for salience processing and executive control. Journal of Neuroscience, 27(9), 2349–2356.
35. Silk, J. S., Siegle, G. J., Lee, K. H., Nelson, E. E., Stroud, L. R., & Dahl, R. E. (2014). Increased neural response to peer rejection associated with adolescent depression and pubertal development. Social Cognitive and Affective Neuroscience, 9(11), 1798–1807.
36. Slavich, G. M., O'Donovan, A., Epel, E. S., & Kemeny, M. E. (2010). Black sheep get the blues: A psychobiological model of social rejection and depression. Neuroscience and Biobehavioral Reviews, 35(1), 39–45.
37. Snaith, R., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995). A scale for the assessment of hedonic tone. The Snaith-Hamilton Pleasure Scale. British Journal of Psychiatry, 167, 99–103.
38. Somerville, L. H., Jones, R. M., & Casey, B. J. (2010). A time of change: Behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain and Cognition, 72(1), 124–133.
39. Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (1970). Test Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
40. Williams, K. D., Cheung, C. K., & Choi, W. (2000). Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology, 79(5), 748–762.
41. Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001). Temporal autocorrelation in univariate linear modeling of FMRI data. NeuroImage, 14(6), 1370–1386.
42. Zimmer-Gembeck, M. J., Nesdale, D., Webb, H. J., Khatibi, M., & Downey, G. (2016). A Longitudinal Rejection Sensitivity Model of Depression and Aggression: Unique Roles of Anxiety, Anger, Blame, Withdrawal and Retribution. Journal of Abnormal Child Psychology, 44(7), 1291–1307.