TLR-3/9 agonists synergize with anti-ErbB2 mAb - Letter

Cancer Research

Volumn 77, Issue 12, 2017, Pages 3376-3378

  Turaj, Anna H ^a   Dahal, Lekh N ^a   Beers, Stephen A ^a   Cragg, Mark S ^a   Lim, Sean H ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ASIALO GM1 ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FC RECEPTOR; IMMUNOGLOBULIN G; INTERFERON; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY ERBB2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ERBB2 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TRASTUZUMAB;

ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; B LYMPHOCYTE; BREAST TUMOR; CD8+ T LYMPHOCYTE; CELL PHAGOCYTOSIS; CYTOLYSIS; DRUG FORMULATION; DRUG POTENTIATION; HUMAN; LETTER; MACROPHAGE FUNCTION; MURINE MODEL; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL;

HUMANS; RECEPTOR, ERBB-2; TOLL-LIKE RECEPTORS; TRASTUZUMAB;

EID: 85021150326     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-17-0412     Document Type: Letter

References (5)

1. Charlebois R, Allard B, Allard D, Buisseret L, Turcotte M, Pommey S, et al. PolyI:C and CpG synergize with anti-ErbB2 mAb for treatment of breast tumors resistant to immune checkpoint inhibitors. Cancer Res 2017;77:312-9.
2. Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. NK celldepleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. J Immunol 2011;186:5766-71.
3. Kawase I, Urdal DL, Brooks CG, Henney CS. Selective depletion of NK cell activity in vivo and its effect on the growth of NK-sensitive and NK-resistant tumor cell variants. Int J Cancer 1982;29:567-74.
4. Beers SA, Chan CH, James S, French RR, Attfield KE, Brennan CM, et al. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 2008;112:4170-7.
5. Gordan S, BiburgerM, Nimmerjahn F. bIgG time for large eaters: monocytes andmacrophages as effector and target cells of antibody-mediated immune activation and repression. Immunol Rev 2015;268:52-65.