Glycan profiling shows unvaried N-Glycomes in MSC clones with distinct differentiation potentials

Frontiers in Cell and Developmental Biology

Volumn 4, Issue MAY, 2016, Pages

  Wilson, Katherine M ^a   Thomas Oates, Jane E ^a   Genever, Paul G ^a   Ungar, Daniel ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

FANGS; Immunomodulatory MSCs; MALDI MS; Multi lineage differentiation; N glycan; Self renewal

Indexed keywords

EID: 85020907684     PISSN: None     EISSN: 2296634X     Source Type: Journal    
DOI: 10.3389/fcell.2016.00052     Document Type: Article

References (18)

1. Abdul Rahman, S., Bergstrom, E., Watson, C. J., Wilson, K. M., Ashford, D. A., Thomas, J. R., et al. (2014). Filter-Aided N-Glycan Separation (FANGS): a convenient sample preparation method for mass spectrometric N-glycan profiling. J. Proteome Res. 13, 1167-1176. doi: 10.1021/pr401043r
2. Amano, M., Yamaguchi, M., Takegawa, Y., Yamashita, T., Terashima, M., Furukawa, J., et al. (2010). Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation. Mol. Cell. Proteomics 9, 523-537. doi: 10.1074/mcp.M900559-MCP200
3. An, H. J., Gip, P., Kim, J., Wu, S., Park, K. W., McVaugh, C. T., et al. (2012). Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Mol. Cell. Proteomics 11:M111.010660. doi: 10.1074/mcp.M111.010660
4. Bartholomew, A., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K., Patil, S., et al. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp. Hematol. 30, 42-48. doi: 10.1016/S0301-472X(01)00769-X
5. Dodla, M. C., Young, A., Venable, A., Hasneen, K., Rao, R. R., Machacek, D. W., et al. (2011). Differing lectin binding profiles among human embryonic stem cells and derivatives aid in the isolation of neural progenitor cells. PLoS ONE 6:e23266. doi: 10.1371/journal.pone.0023266
6. Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317. doi: 10.1080/14653240600855905
7. Gooi, H. C., Feizi, T., Kapadia, A., Knowles, B. B., Solter, D., and Evans, M. J. (1981). Stage-specific embryonic antigen involves alpha 1 goes to 3 fucosylated type 2 blood group chains. Nature 292, 156-158. doi: 10.1038/292156a0
8. Hamouda, H., Ullah, M., Berger, M., Sittinger, M., Tauber, R., Ringe, J., et al. (2013). N-glycosylation profile of undifferentiated and adipogenically differentiated human bone marrow mesenchymal stem cells: towards a next generation of stem cell markers. Stem Cells Dev. 22, 3100-3113. doi: 10.1089/scd.2013.0108
9. Hasehira, K., Tateno, H., Onuma, Y., Ito, Y., Asashima, M., and Hirabayashi, J. (2012). Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells. Mol. Cell. Proteomics 11, 1913-1923. doi: 10.1074/mcp.M112.020586
10. Heiskanen, A., Hirvonen, T., Salo, H., Impola, U., Olonen, A., Laitinen, A., et al. (2009). Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage. Glycoconj. J. 26, 367-384. doi: 10.1007/s10719-008-9217-6
11. James, S., Fox, J., Afsari, F., Lee, J., Clough, S., Knight, C., et al. (2015). Multiparameter analysis of human bone marrow stromal cells identifies distinct immunomodulatory and differentiation-competent subtypes. Stem Cell Rep. 4, 1004-1015. doi: 10.1016/j.stemcr.2015.05.005
12. Li, Y. L., Wu, G. Z., Zeng, L., Dawe, G. S., Sun, L., Loers, G., et al. (2009). Cell surface sialylation and fucosylation are regulated by the cell recognition molecule L1 via PLCgamma and cooperate to modulate embryonic stem cell survival and proliferation. FEBS Lett. 583, 703-710. doi: 10.1016/j.febslet.2009.01.013
13. Nairn, A. V., Aoki, K., Dela Rosa, M., Porterfield, M., Lim, J. M., Kulik, M., et al. (2012). Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J. Biol. Chem. 287, 37835-37856. doi: 10.1074/jbc.M112.405233
14. Nauta, A. J., and Fibbe, W. E. (2007). Immunomodulatory properties of mesenchymal stromal cells. Blood 110, 3499-3506. doi: 10.1182/blood-2007-02-069716
15. Pittenger, M. F., MacKay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147. doi: 10.1126/science.284.5411.143
16. Uematsu, R., Furukawa, J., Nakagawa, H., Shinohara, Y., Deguchi, K., Monde, K., et al. (2005). High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. Mol. Cell. Proteomics 4, 1977-1989. doi: 10.1074/mcp.M500203-MCP200
17. Wada, Y., Azadi, P., Costello, C. E., Dell, A., Dwek, R. A., Geyer, H., et al. (2007). Comparison of the methods for profiling glycoprotein glycans-HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycobiology 17, 411-422. doi: 10.1093/glycob/cwl086
18. Yagi, H., Saito, T., Yanagisawa, M., Yu, R. K., and Kato, K. (2012). Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway. J. Biol. Chem. 287, 24356-24364. doi: 10.1074/jbc.M112.365643