Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 24, 2017, Pages 6358-6363

  Matsui, Takashi ^a   Omuro, Hideki ^a   Liu, Yu Fan ^a   Soya, Mariko ^a   Shima, Takeru ^a   Mcewen, Bruce S ^b   Soya, Hideaki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Atp; Brain glycogen; Endurance capacity; Lactate transport; Metabolomics

Indexed keywords

1,4 DIDEOXY 1,4 IMINO DEXTRO ARABINITOL; ADENOSINE TRIPHOSPHATE; ALPHA CYANO 4 HYDROXYCINNAMIC ACID; ARABINITOL; GLYCOGEN; LACTIC ACID; UNCLASSIFIED DRUG; ALPHA-CYANO-4-HYDROXYCINNAMATE; COUMARIC ACID; MONOCARBOXYLATE TRANSPORTER; SLC16A7 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN METABOLISM; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; ENDURANCE; ENERGY TRANSFER; EXERCISE; EXHAUSTION; GLYCOGENOLYSIS; HIPPOCAMPUS; MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; DRUG EFFECT; ENERGY METABOLISM; FATIGUE; MALE; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; BRAIN; COUMARIC ACIDS; ENERGY METABOLISM; FATIGUE; GLYCOGEN; GLYCOGENOLYSIS; LACTIC ACID; MALE; METABOLOMICS; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE, SKELETAL; PHYSICAL EXERTION; RATS; RATS, WISTAR;

EID: 85020703507     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1702739114     Document Type: Article

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