Efficient self-emulsification via cooling-heating cycles

Nature Communications

Volumn 8, Issue , 2017, Pages

  Tcholakova, Slavka ^a   Valkova, Zhulieta ^a   Cholakova, Diana ^a   Vinarov, Zahari ^a   Lesov, Ivan ^a   Denkov, Nikolai ^a   Smoukov, Stoyan K ^b  

^a UNIVERSITY OF SOFIA   (Bulgaria)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CETRIMIDE; DRUG CARRIER; LIPID; SOLVENT;

CRYSTAL; DROPLET; DRUG; EMULSION; HEATING; LIPID; SOLUBILITY; SOLVENT; SURFACTANT; TEMPERATURE EFFECT;

ARTICLE; CONTROLLED STUDY; COOLING; CRYSTAL; EMULSION; ENERGY; HEATING; MELTING POINT; REDUCTION (CHEMISTRY); SOLUBILITY; TEMPERATURE SENSITIVITY;

EID: 85020695032     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15012     Document Type: Article

References (69)

1. Dinsmore, A. D. et al. Colloidosomes: selectively permeable capsules composed of colloidal particles. Science 298, 1006-1009 (2002).
2. Glotzer, S. C. & Solomon, M. J. Anisotropy of building blocks and their assembly into complex structures. Nat. Mater. 6, 557-562 (2007).
3. Wang, Y. et al. Colloids with valence and specific directional bonding. Nature 491, 51-55 (2012).
4. Xia, Y., Xiong, Y., Lim, B. & Skrabalak, S. E. Shape-controlled synthesis of metal nanocrystals: simple chemistry meets complex physics? Angew. Chem. Int. Ed. 48, 60-103 (2009).
5. Cölfen, H. & Antonietti, M. Mesocrystals: inorganic superstructures made by highly parallel crystallization and controlled alignment. Angew. Chem. Int. Ed. 44, 5576-5591 (2005).
6. Studart, A., Shum, H. & Weitz, D. Arrested coalescence of particle-coated droplets into nonspherical supracolloidal structures. J. Phys. Chem. B 113, 3914-3919 (2009).
7. Smoukov, S. K. et al. Scalable liquid shear-driven fabrication of polymer nanofibers. Adv. Mater. 27, 2642-2647 (2015).
8. Schubert, H. & Engel, R. Product and formulation engineering of emulsions. Chem. Eng. Res. Design 82, 1137-1143 (2004).
9. Bibette, J., Leal Calderon, F. & Poulin, P. Emulsions: basic principles. Rep. Prog. Phys. 62, 969-1033 (1999).
10. Mason, T. G., Wilking, J. N., Meleson, K., Chang, C. B. & Graves, S. M. Nanoemulsions: formation, structure, and physical properties. J. Phys. Condens. Matter 18, R635-R666 (2006).
11. Solans, C. & Sole, I. Nano-emulsions: formation by low energy methods. Curr. Opin. Colloid Interface Sci. 17, 246-254 (2012).
12. Perazzo, A., Preziosi, V. & Guido, S. Phase inversion emulsification: current understanding and applications. Adv. Colloid Interface Sci. 222, 581-599 (2015).
13. Pouton, C. W. Formulation of self-emulsifying drug delivery systems. Adv. Drug Deliv. Rev. 25, 47-58 (1997).
14. Gursoy, R. N. & Benita, S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed. Pharmacother. 58, 173-82 (2004).
15. Sitnikova, N. L., Sprik, R., Wegdam, G. & Eiser, E. Spontaneously formed transanethol/ water/alcohol emulsions: mechanism of formation and stability. Langmuir 21, 7083-7089 (2005).
16. Vitale, S. A. & Katz, J. L. Liquid droplet dispersions formed by homogeneous liquid-liquid nucleation: the Ouzo effect. Langmuir 19, 4105-4110 (2003).
17. Ganachaud, F. & Katz, J. L. Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulsification as an alternative to ultrasonic and high-shear devices. ChemPhysChem 6, 209-216 (2005).
18. Feng, J. et al. Nanoemulsions obtained via bubble-bursting at a compound interface. Nat. Phys. 10, 606-612 (2014).
19. Feng, J. et al. A scalable platform for functional nanomaterials via bubblebursting. Adv. Mater. 28, 4047-4052 (2016).
20. Denkov, N. D., Tcholakova, S., Lesov, I., Cholakova, D. & Smoukov, S. K. Self-shaping of oil droplets via the formation of intermediate rotator phases upon cooling. Nature 528, 392-395 (2015).
21. Cholakova, D., Denkov, N. D., Tcholakova, S., Lesov, I. & Smoukov, S. K. Control of drop shape transformations in cooled emulsions. Adv. Colloid Interface Sci. 235, 90-107 (2016).
22. Nakashima, T., Shimizu, M. & Kukizaki, M. Particle control of emulsion by membrane emulsification and its applications. Adv. Drug Deliv. Rev. 45, 47-56 (2000).
23. Vladisavljević, G. T. & Williams, R. A. Recent developments in manufacturing emulsions and particulate products using membranes. Adv. Colloid Interface Sci. 113, 1-20 (2000).
24. Christov, N. C. et al. Capillary mechanisms in membrane emulsification: oil-inwater emulsions stabilized by Tween 20 and milk proteins. Colloids Surf. A 209, 83-104 (2002).
25. Svarovsky, L. Solid-Liquid Separation 4th edn (Butterworth-Heinemann, 2000).
26. Mejia, A. F., He, P., Luo, D., Marquez, M. & Cheng, Z. Uniform discotic wax particles via electrospray emulsification. J. Colloid Interface Sci. 334, 22-28 (2009).
27. Shinohara, Y. et al. Observation of the transient rotator phase of n-hexadecane in emulsified droplets with time-resolved two-dimensional small- and wideangle X-ray scattering. Phys. Rev. Lett. 94, 097801 (2005).
28. Shinohara, Y. et al. Microbeam X-ray diffraction analysis of interfacial heterogeneous nucleation of n-hexadecane inside oil-in-water emulsion droplets. Cryst. Growth Des. 8, 3123-3126 (2008).
29. Ueno, S., Hamada, Y. & Sato, K. Controlling polymorphic crystallization of nalkane crystals in emulsion droplets through interfacial heterogeneous nucleation. Cryst. Growth Des. 3, 935-939 (2003).
30. Hamada, Y., Kobayashi, I., Nakajima, M. & Sato, K. Optical and interfacial tension study of crystallization of n-alkane in oil-in-water emulsion using monodispersed droplets. Cryst. Growth Des. 2, 579-584 (2002).
31. Xie, B. et al. Crystallization behaviors of n-nonadecane in confined space: observation of metastable phase induced by surface freezing. J. Phys. Chem. B 110, 14279-14282 (2006).
32. Xie, B., Liu, G., Jiang, S., Zhao, Y. & Wang, D. Crystallization behaviors of n-octadecane in confined space: crossover of rotator phase from transient to metastable induced by surface freezing. J. Phys. Chem. B 112, 13310-13315 (2008).
33. Fu, D., Liu, Y., Su, Y., Liu, G. & Wang, D. Crystallization behavior of binary even-even n-alkane mixtures in microcapsules: effect of composition and confined geometry on solid-solid phase separation. J. Phys. Chem. B 115, 4632-4638 (2011).
34. Fu, D. et al. Binary n-alkane mixtures from total miscibility to phase separation in microcapsules: enrichment of shorter component in surface freezing and enhanced stability of rotator phases. J. Phys. Chem. B 116, 3099-3105 (2012).
35. Gao, X., Fu, D., Xie, B., Su, Y. & Wang, D. Confined phase diagram of binary n-alkane mixtures within three-dimensional microcapsules. J. Phys. Chem. B 118, 12549-12555 (2014).
36. Guttman, S. et al. How faceted liquid droplets grow tails. Proc. Natl Acad. Sci. USA 113, 493-496 (2016).
37. Guttman, S., Ocko, B., Deutsch, M. & Sloutskin, E. From faceted vesicles to liquid icoshedra: where topology and crystallography meet. Curr. Opin. Colloid Interface Sci. 22, 35-40 (2016).
38. Scheludko, A. Thin liquid films. Adv. Colloid Interface Sci. 1, 391-464 (1967).
39. Ivanov, I. B. (ed.) Thin Liquid Films: Fundamentals and Applications (Marcel Dekker, 1988).
40. Vrij, A. & Overbeek, J. Th. G. Rupture of thin liquid films due to spontaneous fluctuations in thickness. J. Am. Chem. Soc. 90, 3074-3078 (1968).
41. Petkova, R., Tcholakova, S. & Denkov, N. D. Foaming and foam stability for mixed polymer-surfactant solutions: effects of surfactant type and polymer charge. Langmuir 28, 4996-5009 (2012).
42. Binks, B. P. & Rocher, A. Effects of temperature on water-in-oil emulsions stabilised solely by wax microparticles. J. Colloid Interface Sci. 335, 94-104 (2009).
43. Stone, H. A. Dynamics of drop deformation and breakup in viscous fluids. Annu. Rev. Fluid Mech. 26, 65-102 (1994).
44. Eggers, J. & Villermaux, E. Physics of liquid jets. Rep. Prog. Phys. 71, 036601 (2008).
45. Mora, S., Phou, T., Fromental, J. M., Pismen, L. M. & Pomeau, Y. Capillary driven instability of a soft solid. Phys. Rev. Lett. 105, 214301-214304 (2010).
46. Zhang, K. Rheological Characterization of Dental Waxes. PhD thesis, Eberhard- Karls-Univ. Tubingen (2004).
47. de Gennes, P. G. Wetting: statics and dynamics. Rev. Mod. Phys. 57, 827-863 (1985).
48. Kraack, H., Deutsch, M. & Sirota, E. B. n-Alkane homogeneous nucleation: crossover to polymer behaviour. Macromolecules 33, 6174-6184 (2000).
49. Israelachvili, J. N. Intermolecular and Surface Forces 3rd edn (Academic, 2011).
50. Sedev, R. Limiting area per molecule of nonionic surfactants at the water/air interface. Langmuir 17, 562-564 (2001).
51. Wilkinson, K. M., Bain, C. D., Matsubara, H. & Aratono, M. Wetting of surfactant solutions by alkanes. ChemPhysChem 6, 547-555 (2005).
52. Wilkinson, K., Qunfang, L. & Bain, C. Freezing transitions in mixed surfactant/alkane monolayers at the air-solution interface. Soft Matter 2, 66-76 (2006).
53. Kreulen, H. P. Fractionation and winterization of edible fats and oils. J. Am. Oil Chem. Soc. 53, 393-396 (1976).
54. Haraldsson, G. Separation of saturated/unsaturated fatty acids. J. Am. Oil Chem. Soc. 61, 219-222 (1984).
55. Hirasaki, G. J. Wettability: fundamentals and surface forces. SPE Format. Eval. 6, 217-226 (1991).
56. Davies, J. T. A physical interpretation of drop sizes in homogenizers and agitated tanks, including the dispersions of viscous oils. Chem. Eng. Sci. 42, 1671-1676 (1987).
57. Butt, J. B. Reaction Kinetics and Reactor Design 2nd edn (Marcel Dekker, 2000).
58. Maindarkar, S. N., Hoogland, H. & Henson, M. A. Achieving target emulsion drop size distributions using population balance equation models of high-pressure homogenization. Ind. Eng. Chem. Res. 54, 10301-10310 (2015).
59. Shum, H. C., Kim, J.-W. & Weitz, D. A. Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability. J. Am. Chem. Soc. 130, 9543-9549 (2008).
60. Utada, A. S. et al. Monodisperse double emulsions generated from a microcapillary device. Science 308, 537-541 (2005).
61. Kim, J.-W., Utada, A. S., Fernández-Nieves, A., Hu, Z. & Weitz, D. A. Fabrication of monodisperse gel shells and functional microgels in microfluidic devices. Angew. Chem. Int. Ed. 46, 1819-1822 (2007).
62. Mitragotri, S. & Lahann, J. Physical approaches to biomaterial design. Nat. Mater. 8, 15-23 (2009).
63. Champion, J. A., Katare, Y. K. & Mitragotri, S. Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J. Control. Release 121, 3-9 (2007).
64. McClements, D. J. Nanoparticle and Microparticle-based Delivery Systems (CRC Press, 2015).
65. Olbrich, C., Kayser, O. & Müller, R. H. Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN) - effect of surfactants, storage time and crystallinity. Int. J. Pharm. 237, 119-128 (2002).
66. Bachmann, P. A., Walde, P., Luisi, P. L. & Lang, J. Self-replicating reverse micelles and chemical autopoiesis. J. Am. Chem. Soc. 112, 8200-8201 (1990).
67. Bachmann, P. A., Walde, P., Luisi, P. L. & Lang, J. Self-replicating micelles: aqueous micelles and enzymatically driven reactions in reverse micelles. J. Am. Chem. Soc. 113, 8204-8209 (1991).
68. Browne, K. P., Walker, D. A., Bishop, K. J. M. & Grzybowski, B. A. Self-division of macroscopic droplets: partitioning of nanosized cargo into nanoscale micelles. Angew. Chem. Int. Ed. 49, 6756-6759 (2010).
69. Denkova, P. et al. Evaluation of the precision of drop-size determination in oil/water emulsions by low-resolution NMR spectroscopy. Langmuir 20, 11402-11413 (2004).